The Case for High Dose Vitamin D as Alternative or Adjunct Therapy

Red

 

Recent studies suggest the importance of Vitamin D3 in immunity, and indeed, Vitamin D3 deficiency has been linked to multiple sclerosis, rheumatoid arthritis, hypertension, heart disease, depression, diabetes, chronic pain, osteoporosis and many other illnesses.   Since these diseases have also been linked via studies with Chlamydia pneumoniae (and other pathogen) infection(s), the associated link with Vitamin D3 deficiency might be considered telling.

Vitamin D3 has also been shown via studies to play an important role in host defense against pathogens by promoting the production of the human antimicrobial peptides, cathelicidins (LL-37). These cathelicidins have been found to have broad spectrum antimicrobial activity, showing activity via studies against a host of bacteria, viruses and fungi.  

Importantly, because the antibacterial activity of these antimicrobial peptides involves binding to components of the bacterial cell walls which then allows for a disruption of the bacterial membranes, it is assumed that it would be very unusual for bacterial resistance to occur against these antimicrobial peptides.  Also, and very importantly for C. pneumoniae infections, in addition to their antimicrobial effects, these antimicrobial peptides have been shown via studies to have LPS binding activity and have been shown via studies to reduce the incidence of septic shock in animal models of endotoxemia.     Vitamin D has also been shown via studies to have important immunomodulating activitity, which is important in treating the runaway inflammation that occurs in so many disease associated with C. pneumoniae and other infections.

While human cathelicidins have been shown to have little or no direct effect against C. pnuemoniae, Vitamin D3 has been shown to disrupt the mechanism that the intracellular forms of C. pneumoniae use to prevent normal celluar apoptosis (via its effects on NF-Kappa B and inhibitor of apoptosis proteins), and it is believed that Vitamin D3 is active against the intracellular forms of C. pneumoniae through this mechanism.  That is, Vitamin D3 is believed to disrupt C. pneumoniae's ability to parasitize cells and replicate while inside them.   

In other words, Vitamin D3 is likely active against both intracellular forms of C. pneumoniae.   Combined with the LPS binding effect of the antimicrobial peptides that it has been shown to induce, this would make Vitamin D3 a logical candidate for use in C. pneumoniae treatment. 

The addition of N-acetyl cysteine (NAC) would theoretically then provide treatment against all three forms of C. pneumoniae as well as many other pathogens that may be involved in C. pneumoniae related diseases.    Perhaps too, via its LPS binding and immunomodulating effects, Vitamin D3 + NAC therapy might provide treatment for C. pneumoniae with fewer negative side-effects than traditional CAP therapy.  

More information on Vitamin D3, its antimicrobial effects and other mechanisms of action can be found in the following Handbook thread:

Cpn Handbook:  Importance of Vitamin D - in short

 

 

Im doing this protocol. Started Nac in may-08 with not much problem,just some smaller nac -flu. Started 2000 iu of D3 end of may-08. Before was just on a smaller dose. In september had worked my way up to 8000 iu.

And  since then I take 8000-10000 iu a day. Im having both endotoxin and porphyria reactions. I think this is helping me to kill some cpn!

Im also on AllicinMax since almost a year and I get the same dieoff reactions from this, so I think this is also killing some cpn!

So im very happy for this and I think that my time on CAP will be less because im already killed some cpn. Since I cant find a doc to help with CAP im glad that I learned about this and I feel im getting better.Before I started allicin I was just feeling sicker and sicker.

Best Wishes, Maria

Cpn since sep 2006. Autoimmune thyroid,hypofunction.levaxin,b12+folic acid.All classic cpn,porphyria and toxinsymtoms.Not able to work.Selftreating cpninfection with AllicinMax(garlic), NAC, high vitamin D3. CAP for over 3 years. Back to work and life

Red

Hi Maria,

So glad to hear you are getting better.    Above all else, this is the most important thing!

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

Red,

You got my attention.  Can you post links to the papers you're reading that are recommending these doses of D3?  I'm with you on the NAC, Kim's been on 5g of NAC daily long before we knew about CAP.  I can somewhat back that up, if you want to play phone tag with a researcher in Canada.  Dr. Sriram wanted Kim to bump up her D to 50,000/wk - but it was D2.  SO he was fine with us going to 48,000/wk of D3.

Ken

In pursuit of ABX

Don't Allow What You Know To Get In The Way Of What Might Be

Red

Hi Ken,

Sure.  Read the article, "Use of Vitamin D in Clinical Practice" that can be found from here:

http://www.cpnhelp.org/importance_of_vitamin_d_p#comment-44341 

It's well referenced.   Note the discussion about the importance of testing 25(OH)D levels to make sure your blood levels are in the range of 55-70ng/mL as actual doses to get to this level may vary.   Note too the discussion of large loading doses to get the blood levels up quickly.   Be careful though as, if Kim has any problems with secondary porphyria, Vit D3 can really ramp these up...    

If you cannot get your doctor to test, the Vitamin D Council has provided a link to a reliable home test that can be found from here:

http://www.cpnhelp.org/importance_of_vitamin_d_p#comment-44421

Hope this helps.   Hang in there!

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

Red and Ken, I will be tested and recieve my 25(OH)D level in the next several weeks.  I have been on the 10,000IU D3 for the past 11 weeks. 

My first testing was done May, 24, 2007 but a Quest Lab Draw whose methods of testing  have been called into question recently and whose scale reference range at the time was 20 - 100 ng/mL my test from them at that time was  34.  It may likely have been below range in reality.  My in take dose was 400IU in a multi vit complex this was prior to any treatment for my CFS/FMS syndrome symptoms.  For years, earlier in life, I had supplemented with separate A&D fish oil  a la Adelle Davis information, considering the vintage circa 1973, her referenced information and plan was amongst the best nutrional based information at the time available to the general public. I have been supplementing and using diet for health improvement for 35 years.  And you can still get ill obviously. Still I as weller in my illness than many.

My second test level was Dec, 2007, I was taking D3 2000-3000IU/day.  My level for 25(OH)D3 was 22 on the Arup Labs, SLC UT,  scale of 30-80ng/mL  with Lab parameter:

Deficiency: Less than 20 ng/mL,  Insufficiency:  20-29 ng/mL,  Optimum Level: 30-80 Mg/ML.

My Third Test was June 18, 2008 Arup Lab.  I had loaded with 6000IU during the Winter and Spring and in April cut back to D3 to 4000IU/day 8 weeks prior to testing result was 43, mid range.

My Fourth Test was on Oct 23,2008 I had remained on the D3 dosage of 4000IU/day and had slipped back to 29ng/mL. 

 

We agreed to increase he suggested 8000IU but with conversation with my suggestion after reading some of the reference materials here I suggested 10,000IU and a retest after 2 mos, he was happy with that suggestion. 

I am awaiting lab requestions to test hopefully this week.  I am anxious to reevaluate my total picture.   Per our conversation my target range for treatment is 100ng/mL.  We were first treating bone health now it has expanded to pathogen adjunct treatment as well and the upper level is warranted in my providers suggestion to me.  

Added information posted on 1/22/09  Fifth test level (after 3 months taking D3 10,000IU/day dosage) now 68ng/mL.

I have been in treatment with CAP over 18 months at present. Starting Abx June 24, 2007.

Louise

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
Red

Hi Louise,

Goot luck.   Hopefully the latest test will show much higher levels.   Let us know what your results are...

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

Red, I recently had a brush with what I think was a shingles outbreak. I only showed a few small blisters on my forehead and above my right eye. Even though there wasn't a full on rash of blisters, I had the creepy crawly nerve sensations, burning pain in the skin, headaches, fever and chills. Fatigue lasted for a few days during the worst of it. Insomia even returned for a few nights.

I was taking 8,000 iu of D3 at the time this occured. Afterward, I added more to total 10,000 iu. I'm convinced that the D3 along with the Nitro Patch saved me from a more severe outbreak.

What I also took: 3 grams of Lysine a day, Olive Leaf extract, lots of C, Allacin (garlic extract) and Licorice tea. (along with the usual supplements).

I think it is interesting that I came down with this 6 days after my first Tini pulse. Herpes infections are opportunists--where there is inflammation, they take advantage of it.

Thanks for all your post about D!

Raven

Feeling 98% well-going for 100. Very low test for Cpn. CAP since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NAC,BHRT, MethyB12 FIR Sauna. 1-18-11 begin new treatment plan with naturopath

Red

You're welcome Raven. 

FYI, and this may have come from you, but someone told me that Dr P suggested making a paste of Vit D (by emptying a capsule into a bit of water) and putting it on a sore to make it heal faster.   Well, I suggested my niece try this with a shingles outbreak and she broke open a vit D cap and mixed it in with some body lotion and then rubbed it into the area she had with shingles.   It cleared it up for her in a week.    She then stopped and the shingles came back, so she did it again and it went away again in @ a week.    She continued it for a little while after to make sure it didn't come back, and last I heard it had cleared up totally.

It's not too surprising, really, given it's understood actions against viruses, but thought I'd pass it on in case it might help you...

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

Red,

There is a topical rx cream called Dovonex which is synthetic D3.  I use it on psoriasis lesions and I know of another lady that does too.  It works really well if you use it consistently when in an active outbreak.

 

NAC 2.4g, Zith 250mg/MWF, mino 200mg, Tini 5day/1g/5 pulses, Valcyte
Supplements, CFIDS/FMS, Hashimoto's, Psoriasis, PA, IBS, Sec Addisons

Don't believe everything you think!  

Red, Were you the person who posted the youtube link for a video presentatation by a Research MD at Stamford a talk given about about Vitamin D, just the other day?  I am looking through all the Vit D3 related topics and blogs and even though I down loaded it with Realtimeplayer I wanted to make mention of it to Raven.  There was a passing humorous reference in the presentation to topical vitD3 and some of the researchers (use for baldness, it was towards the end of the 30 minute).  Oh yes it was your reference somewhere could have been in my blog even now it comes back to me a bit.

I'll look again there and see if I can add it in here.  Raven it is well worth the half hour or so, very well presented.

Here is the link to that lecture that I was talking about above:

Vitamin D: It's Not Just For Bones Anymore, presented by David
Feldman
, MD, professor of medicine at Stanford:
http://youtube.com/watch?v=qpFgy8RkWO0

Louise

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Thanks Red, I will try grinding up some and using it on the skin. I am having good luck with topical Allacin ointment alternating with some prescription Trentoinin.The blisters are almost gone and I feel so much better.

Louise, thanks for bringing up the video. I have watched it several times and sent it to many of my friends and family. It's up to us to get the word out on D.

 

Raven

Feeling 98% well-going for 100. Very low test for Cpn. CAP since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NAC,BHRT, MethyB12 FIR Sauna. 1-18-11 begin new treatment plan with naturopath

Raven, Please take a look at my LDN topic just added this morning if you get a chance.  I see by your notes in your signature that is on your treatment plan.  I do not want to shift the discussion here.  Louise
  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Thanks Red for sharing that link.  I have used some of their other products in the past before I have had bioidentical supports as prescriptions.  I had picked them up at the local store. I didn't know that they manufactured this one also.   Louise
  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Following up on my intention to post My level for 25(OH)D3, I also inserted the results above with the other 4 values that have been obtained over time.

Lab draw on 1/16/09 after 3 months on Vit D3 taken at 10,000IU dosage,  68ng/mL. (No sun exposure during this period, there is a foot of beautiful powder snow here just now!)

Louise

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
Red

Great to hear, Ken!   Let us know what you hear on the results...

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-