Help me figure out what is going on-please! I was diagnosed 3 weeks ago with EBVi and CMV. My numbers were very high and dr. put me on Valtrex 3 gm./day, Lysine 3 gm./day and Guna Virus (homeopathic anti-viral). I was ok on the Valtrex until I increased to 2 gms./day. I began to get that flu-like reaction with bad headaches, eyes got drier and burning, IBSi symptoms returned. I backed off to 1500 mg. for the past week. The terrible headache got better but I still feel awful. Could the anti-virals cause a die-off like response? They only suppress the virus right? I still need to get to 3 gms./day and I'm not feeling any better than I did a week ago. Can anyone tell me (in general) how long it might take to get this viral load down?
Also, I was planning to re-start CAPi ASAP. Right now, I feel too bad to add Doxyi for fear of die off response. I'm not functioning already.
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FMSii/CFSii 12 yrs., IBSi, Hypothryoid, EBVi, CMV, Sleep Apnea, Cardiac Arrythemia, Sjorgens, Depression, Brain Fog, Cpnii, On CAPi since 10-1-07, Currently on NACi & Delta Fr. E Valtrex, Lysine, and Guna Virus

FMSi/CFSi 12 yrs., IBSi,
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FMSi/CFSi 12 yrs., IBSi, Hypothryoid, EBVi, CMV, Sleep Apnea, Cardiac Arrythemia, Sjorgens, Depression, Brain Fog, Cpni, On CAPi since 10-1-07, Currently on NACi & Delta Fr. E
Valtrex,Lysine, andGuna VirusHMMMM.... I was wondering if
HMMMM....
I was wondering if that homeopathic might also be anti bacterial.
CFIDSi/ME 25yrs, FMSi, IBSi, EBVi, Cpni, (insomnia - melatonini, GABA, tarazadone, triazolam, novocycloprine, allergy formula, 3 gm tryptophan), Natural HRT peri-M, NACi 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse8 750mg 4day,375X1 3-24-8
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CFIDSi/ME 32 yrs, FMSi,
IBSi, EBVi, CMV, Cpni, chronic insomnia, Lymes, HME, Natural HRT peri-M, NACi 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse#14 1000 mg X 5 days 9-19-08Ruthless, No, its
Ruthless,
No, its Anti-viral. The primary substance that he wanted me to have is interferon. Which, now that you ask, doesn't sound very natural. But, the packaging does say homeopathic. Its made by Guna Inc. (biotherapeutics). The first few ingredients are beta Endorphin 4C, Interferon gammai 3C, Blood, Porcine 4C and Interleukin 2 5C...
FMSi/CFSi 12 yrs., IBSi, Hypothryoid, EBVi, CMV, Sleep Apnea, Cardiac Arrythemia, Sjorgens, Depression, Brain Fog, Cpni, On CAPi since 10-1-07, Currently on NACi only, From Memphis-USA
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FMSi/CFSi 12 yrs., IBSi, Hypothryoid, EBVi, CMV, Sleep Apnea, Cardiac Arrythemia, Sjorgens, Depression, Brain Fog, Cpni, On CAPi since 10-1-07, Currently on NACi & Delta Fr. E
Valtrex,Lysine, andGuna VirusMarcia, i am not well up on
Marcia, i am not well up on antivirals, so really no better off than you on this but my first action when faced with such a question is to turn to google.
This what I found... Nothing about the side effects of Guna Virus apart from the description of the drug and its application, also a bit of a concern for me was the dosage... homeopathic remedies are usually administered in tiny doses... don't know what to make of that as the ingredients you quote don't actually tell us how much of these there is in the dose you are taking.
But for the sake of answering your question I looked at the side effects of another interferon drug, Rebif, a more commonly administered drug for MS and this is what it said about adverse reactions:
The most commonly reported adverse reactions were injection site disorders, influenza-like symptoms (headache, fatigue, fever, rigors, chest pain, back pain, myalgia), abdominal pain, depression, elevation of liver enzymes and hematologic abnormalities.
Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMSi, At worse EDSSi 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006
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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMSi, At worse EDSSi 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006
The homeopathic Guna
The homeopathic Guna Virus looks like quite a mixture of remedies but they are all in very low potencies and unlikely to stimulate the sort of response you seem to be having. It seems to be a general anti-viral rather than a homeopathically prescribed remedy so I'd guess your doctor has given you it as a support while taking the anti-virals (looks interesting though, I'll read up on it) Your observation that upping the Valtrex made you feel worse could be your best clue.
Disclaimer..... I'm a homeopath not a medical doctor so to be safe please check with yours.
Elinor ..... from England on CAPi, doxyi/roxi/tini for ME/CFSi/lyme borreliosis, positive Cpni and borrelia. Started Aug05, stopped Jan06, started again Sept 06.
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Elinor ..... from England on CAPi, doxyi/roxi/tini for ME/CFSi/lyme borreliosis, positive Cpni and borrelia. Started Aug05, stopped Jan06, started again Sept 06.
Elinor, Thanks for the
Elinor,
Thanks for the feedback. I left out an important point. I felt so bad that I didn't do a very good job of explaining things. My head was pounding-almost too sick to ask for help.
You are correct, I did get sick when I increased the Valtrax. It was after this that my doc added Lysine and Guna Virus(yes, more of a supportive role). I've been on all three for a week now. And I still don't feel any better. Shouldn't my body be adjusted to the dose of Valtrax by now?
Any ideas of what I can do to get to feeling better?
Fibromyalgia/CFS 12 yrs., IBSi, Hypothryoid, EBVi, CMV, Sleep Apnea, Cardiac Arrythemia, Sjorgens, Depression, Brain Fog, Cpni, On CAPi since 10-1-07, Currently on NACi only, From Memphis-USA
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FMSi/CFSi 12 yrs., IBSi, Hypothryoid, EBVi, CMV, Sleep Apnea, Cardiac Arrythemia, Sjorgens, Depression, Brain Fog, Cpni, On CAPi since 10-1-07, Currently on NACi & Delta Fr. E
Valtrex,Lysine, andGuna VirusMichele, Thanks for the
Michele,
Thanks for the info. I don't think the dose of interferon is high at all. As Elinor suggested, the Guna Virus is probably more of a supportive thing.
And, I got sick after increasing the Valtrex. That happened about 5 days before my doc added the Lysine and Guna Virus. So, I'm back to the question-Can anti-virals cause a die off like response? And, does anyone have an idea what I can do to get to feeling better?
FMSi/CFSi 12 yrs., IBSi, Hypothryoid, EBVi, CMV, Sleep Apnea, Cardiac Arrythemia, Sjorgens, Depression, Brain Fog, Cpni, On CAPi since 10-1-07, Currently on NACi only, From Memphis-USA
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FMSi/CFSi 12 yrs., IBSi, Hypothryoid, EBVi, CMV, Sleep Apnea, Cardiac Arrythemia, Sjorgens, Depression, Brain Fog, Cpni, On CAPi since 10-1-07, Currently on NACi & Delta Fr. E
Valtrex,Lysine, andGuna VirusMarcia- Montoya of the UCLA
Marcia- Montoya of the UCLA Valcyte studies with CFIDSi reported that a number of patients got significant die-off a couple weeks into the protocol, so it is quite possible that killing viruses (many die in the "suppression") will give a die off. Especially if your viral load is high, which you say it is. 3 grams of Valtrex is a significant dose, and the added lysine will potentiate it. I don't know about the other. But kill those buggers-- they aren't doing you any good!
CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Protocol: 200mg Doxyi, 250mg MWF Azith, Tinii 1000mg/day pulses; Vit D1000 units, Iodoral 50mg, T4 & T3
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CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3
Jim, Thank you, thank you.
Jim,
Thank you, thank you. I couldn't find any information that would clarify things for me. I'm not less sick for having a better understanding-but, at least you have assured me that I'm not crazy. Yes, the dose is significant. In fact, I'm wondering about that. Some on this site were put on 2 grams/day by Dr. Powell. I've checked Rxlist and a couple of others and have not found a dose any higher than 2 grams/day. I'm a little concerned about the dose but my doctor is a toxicologists-surely he realizes the risk???
Here are my lab results.
One of these is acute and one is chronic.
EBii Anti-VCA, IGG >750 U/ml (High)
Ref. > 22.0 U/ml....Positive
EB Virus Nuclear AG, IgG >600 U/ml (High)
Ref. >22.0 U/ml.....Positive
Cytomegalovirus IGGi Antibody 18.0 Units (High)
Ref. >l.l units....Positive
Thanks again, you have eased my mind a lot.
FMSi/CFSi 12 yrs., IBSi, Hypothryoid, EBVi, CMV, Sleep Apnea, Cardiac Arrythemia, Sjorgens, Depression, Brain Fog, Cpn, On CAPi since 10-1-07, Currently on NACi only, From Memphis-USA
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FMSi/CFSi 12 yrs., IBSi, Hypothryoid, EBVi, CMV, Sleep Apnea, Cardiac Arrythemia, Sjorgens, Depression, Brain Fog, Cpni, On CAPi since 10-1-07, Currently on NACi & Delta Fr. E
Valtrex,Lysine, andGuna VirusHi Marcia, I have read that
Hi Marcia,
I have read that die off of a large load of virus can cause significant die off symptoms. My suggestion would be to drop your dosage of Valtrex down to a point where you feel better and then gradually increase the dose as you tolerate it.
Tina-MS 37 years;EDSSi 4.5 1/1/08 Wheldon CAPi; Azith 250mg 3 x a week; Doxyi 200mg daily, NACi 2000 mg daily
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Tina-MSi 37 years;EDSSi 4.5 1/1/08 Wheldon CAPi; Azith 250mg 3 x a week; Doxyi 200mg daily, NACi 2000 mg daily, started Flagyli pulse 4/14/08.
Hi Tina, I'm one of these
Hi Tina,
I'm one of these people who needs to understand what is going on. Everything I read about Valtrex said that it suppressed rather than killed the virus so I couldn't understand why I was experiencing die-off. However, yours and Jim's message helped me understand that some of the virus dies during the suppression-especially when high viral loads are present.
Also, I found a couple of folks on this site who experienced a similar reaction when they took anti-virals. I'm not the only one (thank the Lord).
I did reduce the dose from 2 gms/day to 1500mgs. But, at the same time, I added the Lysine and Guna Virus. From what Jim said, I was probably at the peak time for die off to begin-so I made it worse by adding 2 more anti-virals. Live and learn.
Now that I've learned all of this, I've been on the above for 8 days. I've temporarily dropped the Lysine and Guna Virus. If I don't feel better in the next day or two, I may have to decrease the Valtrex.
Does that sound like a reasonable plan???
Thanks for your help.
FMSi/CFSi 12 yrs., IBSi, Hypothryoid, EBVi, CMV, Sleep Apnea, Cardiac Arrythemia, Sjorgens, Depression, Brain Fog, Cpni, On CAPi since 10-1-07, Currently on NACi only, From Memphis-USA
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FMSi/CFSi 12 yrs., IBSi, Hypothryoid, EBVi, CMV, Sleep Apnea, Cardiac Arrythemia, Sjorgens, Depression, Brain Fog, Cpni, On CAPi since 10-1-07, Currently on NACi & Delta Fr. E
Valtrex,Lysine, andGuna Virus