MediTest
Submitted by Jim K on Fri, 2008-05-09 23:52

Blog 5/08 Warning: this is a lengthy one as it's been a while.It’s been quite a while since I posted a blog. I’ve been experimenting with some things and don’t like to report too much until I have a clear trend going, and that takes months. Now that the experimental protocol is public I can give my own report. I’m also the “old man” of the site, and if newbies see that I’m doing things differently than the “standard” CAP’s it tends to confuse. One of the side costs of our success in bringing more people to the site is that it’s more problematic for me to “think out loud” about my own treatment like I used to here. My musings and speculations tend to be followed with more attention than perhaps they deserve,  and all sorts of questions or concerns pop up for people. I’ve been following an emerging protocol Dr. Stratton has been developing with a friend of his who is a patient-expert on Cpn. The intention of this has been to find ways to alleviate some of the onerous effects of Cpn treatment so that it is easier on people, and to make the treatment process less lengthy. A number of people previously unable to tolerate CAP treatment, older folks especially with GFA syndrome (Generally Falling Apart from Cpn related diseases) have been able to tolerate treatment and benefit from it in a number of months. (Some of the explanation below has been repeated in the Handbook post on the experimental protocol) Emerging research has been suggesting that Cryptic Cpn is not benign even if it is not replicating. Cryptic Cpn is essentially a stressed form of Cpn, and stress causes it to generate of Heat Shock Protein (HSP60), which is many times more inflammatory than LPS endotoxin. LPS endotoxin is the one that causes the fever and chills and is released mostly when RB’s are killed and lyse, or when EB’s are killed. The inflammation of plaques in cardiovascular disease has been associated specifically with Cpn HSP60 (this is a blog, so I’m not going to try to reference all this stuff here, you can look it up in Pubmed) and with the persistent (cryptic) form of Cpn. This is probably why those “big” studies of 6 months of azithromycin showed not lowering of risk of heart disease… it’s not caused by the replicating form of Cpn and the idiots never asked a microbiologist about what might kill cryptic Cpn! Dr. Stratton has been thinking that a lot of the reactions people have to antibiotics in treating Cpn is not all the LPS endotoxin release or porphyrins, but could in large part be from the highly inflammatory effect of forcing Cpn into Cryptic form, causing it to generate a big wave of HSP60, and then a lower but chronic amount until it’s killed by the flagyl. He speculates that some of the reports of IV treatment causing little or no reaction is because it floods the system with so much antibiotic so quickly that the Cpn is killed before it starts to be stressed and generate HSP60 as part of it’s survival strategy. Paul Griffith, a non-medical friend researching this whole area, found that supplementing pyruvate might do the trick. Basically, this approach uses 6grams of calcium pyruvate one hour before taking the antibiotics, and an additional 6 grams if needed later for reactions when the antibiotics exert their effect. In theory the first dose of pyruvate encourages the cryptic/persistent form of Cpn to convert back into RB (replicating) form by supplying it with a ready source for generating cellular energy. In RB form it is: a) Susceptible to the regular antibiotics and, b) Can be killed when it is not in “stress” so it is not stimulated into producing and releasing so much the highly inflammatory HSP60. In essence, you are feeding it until it is comfy and sprawling in it’s chair at the dining table, and then whacking it upside the head! In theory this approach should limit turning Cpn into cryptic form by the treatment and make it more directly susceptible to the protein synthase inhibitors (like doxy and azith). In theory, it should also winnow down the cryptic load one has acquired, along with it’s inflammatory affects, without needing to kill it directly with flagyl. Also in theory, the second dose of pyruvate for reactions to the antibiotics should supply the fundamental cellular energy needed to help lower the generation of porphyrins. Back to my blog… So for the past three months I’ve been experimenting with this using different antibiotic agents, without and pulses. I finally did a tini pulse last week to see whether I had indeed reduced the cryptic load—based on how much reaction I would have to the pulse. My personal speculation is that, if I’ve been building up lots of cryptic load by going so long without a pulse I’d have a strong reaction. If this new approach was itself winnowing down my cryptic load, I would have a relatively mild reaction. Well, it’s only one pulse, but it was the easiest pulse I’ve ever had, and no noticeable post-pulse reaction. So it does seem that this new approach is useful. More importantly to me personally is that I’ve improved noticeably in my energy and cognition after these three months. I had been at a glacially slow improvement phase for a while, so this is really significant for me. Month One- I first did a month of Biaxin (clairithromycin) twice a day in combination with about 4 grams of  pyruvate, without any doxycycline. This combination was not easier on me. In fact I had stronger die-off reactions from this than I’d had in a long time. This was surprising, as I don’t have any significant reactions to the regular antibiotics, only to pulses. It suggested that I was indeed getting previously untouched Cpn to be vulnerable to the antibiotics. In fact, the reactions I was having were more like old pulses used to be: I was getting aches in joints, knees, trapezius muscle, sacroiliac joint, etc. which I only have gotten during pulses. I had a couple weeks of flare up like this on the Biaxin/pyruvate combo. The second dose of pyruvate didn’t help a lot to counter these reactions, but I was only doing 4 grams for these post-antibiotic dose reactions and was told later by Dr. Stratton that this was not sufficient. Month Two- The next month I did roxithromycin and Bactrim DS. I had some roxy left from a past experiment, and wanted to try the Bactrim to see if it helped with urinary symptoms. I had less reactions than on the Biaxin. After about two weeks I actually felt mentally clearer and more energy than I had in a long time! I was still only doing about 4 grams of the pyruvate, but love that roxy/bactrim! Month Three- I ran out of the roxy after a month, and switch back to azithromycin briefly, 250mg daily preceeded by the pyruvate. I got an initial kick, again, but it settled down shortly. About this time I started to use 6grams pyruvate instead of 4. This eliminated most reactions and seemed to improve my energy and mood. Shortly, I got more roxy and switched back to it but also added doxy back as I ran out of Bactrim. I’d say during this month I was functioning well although at about the same level end of the month as at the beginning of the month. He Hits, He Scores, He Pulses… I finally did my usual pulse of 500mg tini twice a day for five days. I had some reaction to the first dose of 1000mg. I usually double the first dose to 1000mg to bring my blood levels up quicker. These reactions were mostly alleviated by additional pyruvate. The rest of the pulse was uneventful: some short periods of irritability and aches that were easily countered by some pyruvate  and a dose of ibuprophen. Post pulse now a week, no post pulse reactions to speak of. I have to say that it does appear that this approach is clearing some stubborn areas of Cpn and also contributing to more energy, cognitive clarity and less inflammation. Almost forgot: the unforgettable rifampin… Ah yes. Somewhere in the middle of all this I tried the pyruvate and rifampin. SLAMMED! I did 150mg rifampin twice a day and could only manage 4 days. Even lots of pyruvate didn’t counter my reactions to this one! So there is still some way to go here for me, as the “acid test” of rifampin is not approachable. In Conclusion- Some of you who have noted how bloody long I’ve been on this protocol may be wondering if it’s really worth it. I’m the poster child (maybe along with Willow?) for starting out with an incredibly high bacterial load and pervasive infection. Every step-up of the protocol, every addition of a stronger agent, cost me in miserable reactions. But I told a friend the other day that I can look back at the last three birthdays and truly say that I have felt better than the last one each time. Not bad for reaching my 55th this weekend! Worth it? You bet. I am living more life than I was able to last year, and so much more than when I started. My patient story spoke of the narrowing tunnel of illness when I started the CAP.  I’m out of the tunnel, in the sunshine and on level ground. That's good!

Happy Birthday, friend. Many more!

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Yes, Happy Birthday, Jim... and thank you for being one of our pioneers (as well as a willing guinea pig Image removed.).  

 

Jeanneroz ~CPN diagnosed and started protocol  4/2007, also have  HHV6, EBV.  CFIDS/FM diagnosed: 6/07; Protocol:  200 mg/doxy daily~ 250 mg AZITH M/W/F ~1st Tindi pulse 4/17/08- 1 250 mg. tab for 2 days. supplements

JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

Jim, What was the dosage of Biaxin that you took?  

Wishing you a very Happy Birthday,

Louise

CFS/ME.CPnPositive.BbPositive.WheldonCAPbegan6/24/07. NowNAC,Doxy, Roxi, /full tini Pulses  with  Cholestyramine at Bedtime for Phorphoria & liposacaride Endotoxin Die-Off experiences as needed post pulse cycle only.

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

And many happy returns, Jim!

Thanks for the newsy and detailed update to your blog. I have been following your progress very closely, especially in recent months. It is great to know how well things are going!

Keep at it, I am inspired! :)

 

[Doxy, Azith, Biaxin and Flagyl]  for rrms since October '05.  Added Amoxicillin 1gm twice daily and LDN 4.5mg qhs October '07; Added Inositol[1gm] and Calcium Pyruvate[4-6gm] daily February '08, EDSS was 6.5,

Wheldon Protocol for rrms since Oct '05.  Added LDN 4.5mg qhs Oct '07.  All supp's.  Positive IGG's for Lyme Disease,Babesia, & Erlichiosis Sept. 2008.  Currently:  Mepron 750mg bid and Azithromycin 250mg qd for Babesia.

Kitkat how long have you been taking Biaxin and at what dosage?  How does it set for you on an empty stomach?

Thanks Jim for sharing that you were taking 500 mg BID, twice a day.

Louise

CFS/ME. CPnPositive. BbPositive. WheldonCAPbegan6/24/07. NowNAC,Doxy, Roxi, Ful TiniPulsees.  intermittent  Cholestyramine  1 = 2 packets at Bedtime only for Phorphoria &l iposacaride Endotoxin Die-Off Experiences 5 to 10 days during pulse cycle as needed work well for me.

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Louise,

I just started the Biaxin this week. Not enough days to see a pattern yet, but it's going well so far. I can probably safely assume it is the reason my knee swelling has gone down.

I take the same as Jim, 500mg twice daily.

 

[Doxy, Azith, Biaxin and Flagyl]  for rrms since October '05.  Added Amoxicillin 1gm twice daily and LDN 4.5mg qhs October '07; Added Inositol[1gm] and Calcium Pyruvate[4-6gm] daily February '08, EDSS was 6.5,

Wheldon Protocol for rrms since Oct '05.  Added LDN 4.5mg qhs Oct '07.  All supp's.  Positive IGG's for Lyme Disease,Babesia, & Erlichiosis Sept. 2008.  Currently:  Mepron 750mg bid and Azithromycin 250mg qd for Babesia.

Happy Birthday! Here's to many more. Onwards and Upwards. Image removed.

 

Berkshire, UK. Diagnosed RRMS Feb 4th 2008.

NAC 2400mg. All supplements. Doxy 200mg. Zith 250mg M/W/F.
No GP/Neuro support. Self medicating with help from David Wheldon.
Started CAP 20th April 2008.

Berkshire, UK. Diagnosed RRMS Feb 4th 2008.NAC 2400mg. All supps. Doxy 200mg. Zith 250mg. Metro 400mg.No GP/Neuro support. Self medicating with help from David Wheldon. Started CAP 20th April

 Thanks all! Kind sentiments. Biaxin dose 500mg twice a day.

CAP for Cpn 11/04. Dx: 25yrs CFS & FMS. Protocol: 200mg Doxy, 300mg Roxithromycin, Tini 1000mg/day pulses; Vit D1000 units, Iodoral 50mg, T4 & T3

  Happy Birthday, Jim!!  I see you are taking roxithromycin now: excellent stuff isn't it?...........Sarah

An Itinerary in Light and Shadow...........Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still slowly improving and no exacerbation since starting. EDSS was 7, now 2, less on a good day.

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Happy birthday Jim...I was wondering how do you schedule out the thyroid med, calcium pyruvate.., did you take the calcium pyruvate one hour before your evening dose of antibiotics? if so, did you take a total of 3 doses of pyruvate per day, or just 2?

Mphs, TN. CFS, hypoT (Hashi), adrenal fatigue, 37 w/hormones of 80,. right arm neuropathy. + cpn, myco, EBV, CMV. NAC 4000mg, doxy 100-2xday, azith 250 m/w/f/sun, progesterone, estriol, synthroid, pulse flagyl, tini<

Mphs, TN. CFS, hypoT (Hashi), adrenal fatigue, hormonal inbalance. right arm neuropathy-getting better. cpn, myco, EBV, CMV, HHV-6. Cap began in 6/07. NAC 2400mg, mino 100mg bid, biaxin 500mg bid. cytomel, flagyl bid continuously.

Jim, I was wondering which antibiotic combo do you feel killed the most, along with the pyruvate?

Mphs, TN. CFS, hypoT (Hashi), adrenal fatigue, 37 w/hormones of 80,. right arm neuropathy. + cpn, myco, EBV, CMV. NAC 4000mg, doxy 100-2xday, azith 250 m/w/f/sun, progesterone, estriol, synthroid, pulse flagyl, tini<

Mphs, TN. CFS, hypoT (Hashi), adrenal fatigue, hormonal inbalance. right arm neuropathy-getting better. cpn, myco, EBV, CMV, HHV-6. Cap began in 6/07. NAC 2400mg, mino 100mg bid, biaxin 500mg bid. cytomel, flagyl bid continuously.

Happy birthday. 

CAP for M.S. since 8/2007. Currently: 100 mg Dox. (2 x day), 250 mg Zith (3 x week) ceased 3/2008, 150 mg Roxi (2 x day) starting 3/2008. Seventh pulse metronidazole completed 4/11/2008.

CAP for M.S. 8/2007 - 3/2009.  Twentieth pulse metronidazole + INH completed 3/12/2009.  Intermittent treatment thereafter until 11/20/2009.  

Thanks for the update Jim - it was well worth the wait. Its front runners like you who make the journey easier for the rest of us.

Hope I can join you soon outside this tunnel!! 

CFS. Started CAP 03-07. Currently: Roxi 600mg + Doxy 200mg + Rifamp 300mg . 13 Pulses done. Sauna every other day. D 7200IU

Hunter: Don't think - experiment

Happy Birthday JimK & Many Happy Returns..

what does that mean anyway "many happy returns"  My Mum would put it on our cards & I don't have any idea what it means.  Happy is self explanatory as is many, but returns?  does that mean many more birthdays to come?

inquiring minds want to know!

Thanks for doing the experiment!  I read with great interest about the energy, less fog!  For Jeannie & others who are slammed with the ME & the CPn I look with interest at getting at the beasts before they dump bad stuff causing us more grief! 

the 9th was my husbands birthday - steady stubborn Taurus!

 

Image removed.

CFIDS/ME 26yrs, FMS, IBS, EBV, CMV, Cpn, chronic insomnia, Lymes, HME, Natural HRT peri-M, NAC 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse#9 750mg 5.5 day, 4-25-8

CFIDS/ME, FMS, MCS, IBS, EBV, CMV, Cpn, H1, chronic insomnia, Chronic Lyme, HME, Babesia, Natural HRT-menopause, NAC 2.4 gm,Full CAP 6-2-07, all supplements+Iodorol, Inositol-depression, ultra Chitosan, L lysine Pulse#27 04-19-10 1gm Flagyl/day-5 days<

Ruth,

To me it means best wishes for many more happy birthdays.

 

[Doxy, Azith, Biaxin and Flagyl]  for rrms since October '05.  Added Amoxicillin 1gm twice daily and LDN 4.5mg qhs October '07; Added Inositol[1gm] and Calcium Pyruvate[4-6gm] daily February '08, EDSS was 6.5,

Wheldon Protocol for rrms since Oct '05.  Added LDN 4.5mg qhs Oct '07.  All supp's.  Positive IGG's for Lyme Disease,Babesia, & Erlichiosis Sept. 2008.  Currently:  Mepron 750mg bid and Azithromycin 250mg qd for Babesia.

 

Tax Returns, maybe?  No, something to do with a ball-game, I think...............Sarah

An Itinerary in Light and Shadow...........Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still slowly improving and no exacerbation since starting. EDSS was 7, now 2, less on a good day.

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Thanks again Jim, have a happy birthday.
Your experiment is certainly very useful and I like to read all what you write. It looks like we might have soon more efficient ways to treat Cpn!

Nino: French Riviera, Cpn pneumonia june05 (misdiagnosed). Self diagnosed-treated. Sept.06 found doctor who confirmed Cpn, prescribed Zit 500mg every sec.day.I added NAC, supplements, metron.pulses, 200mg Doxi , now Roxi 150 mg bid instead of Zit

Nino: French Riviera, Cpn pneumonia june05 (misdiagnosed). IgG 1:1024. Mino 100mg bid, Zith 250mg every other day, NAC 2.4g, Metro 500mg bid pulses.

Red

Happy Birthday, Jim!

And thanks again for all you do (and have done) for us...

On Combined Antibiotic Protocol for Cpn in Rosacea 01/06 - 07/07, On Vit D3 + NAC since 07/07 and daily FIR Sauna since 08/07

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

 - THANKS for your update - that must have taken a while to write, but it will be so appreciated by many.  Hope is so good.

 

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

 HSP60. If IV antibiotics flood the system and kill the cpn before it has time to get stressed preventing the HSP60 toxin, shouldn't we be purusing this method of treatment?  Especially if it speeds up the destruction of the beasties and reduces tretment time? Thanks Jim for posting your interesting editorial on chlamydia, HSP60 and pyruvate.

Tina-MS 37 years;EDSS 4.5   1/1/08 Wheldon CAP; Azith 250mg 3 x a week; Doxy 200mg daily, NAC 2000 mg daily, started Flagyl pulse 4/14/08.

 Tina-MS 37 years;EDSS 4.5   1/1/08 Wheldon CAP; Azith 250mg 3 x a week; Doxy 200mg daily, NAC 2000 mg daily, started Flagyl pulse 4/14/08. 

Jim,
Happy, Happy Birthday!!!!!!!!!!!!!!!
Thanks for your blog of current treatment - very helpful. I have been taking the calcium pryuvate- but not enough. I am taking 2 grams and have had some relief.
Cheers to feeling better!

On Wheldon protocol for MS since April, 2006.  doxy 200 mgs daily, zithromax 250 mgs 3x/ week , Flagyl Pulses start end Sept., LDN 2004. Gad-enhanced MRI of brain and spine shows NO NEW DISEASE ACTIVITY and one lesion diminishing in size on 9/30.

5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tini pulses,100 mg diflucan, 4.5 ldn; Wheldon protocol for MS April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.

Happy Birthday Jim!

So happy you feel better!

Thanks for this website and all the work you do here,it helps me and my family a lot.

Best Wishes,

Maria

Cpn since sep 2006. Autoimmune thyroid,hypofunction.levaxin,b12+folic acid.All classic cpn,porphyria and toxinsymtoms.Not able to work.Selftreating cpninfection with AllicinMax(garlic), NAC, high vitamin D3. CAP for over 3 years. Back to work and life

Jim-Very nice you shared your experience with us. THANK YOU! I dont want to change my current protocol (doxy+azith+NAC) but i think i will add calcium pyruvate as well. One hour before taking the ABX right? I hope these 2 agent does the same effect as Clarith. and Roxy. anyway.

doxy200, azith250, NAC 2400, Metro 1250(once a month), supplements, vitamins.

Like Veressv, I think I may just add the calcium Pyruvate to my current regime.

Could you just clarify Jim, if you used it every day - I assume you did, not just pulse times, etc.

If so, its expensive huh?  As IHerb only sells it in MG not GRAMMES! And i have to order it from the UK. 

Good to hear  that you are still making progress out in the sunshine and on the road.

AH HA - edit - I see in previous thread on this, some people are taking it every day, especially during pulses and thereafter ... i hope that answers my question. 

M.E./CFS 20 years, intermittent.  Wheldon Protocol - Started NAC and supplements Sept 2007. Doxy and Roxy full dose by Dec '07.  First Flagyl pulse January 2008.

M.E./CFS 20 years, intermittent.  Wheldon Protocol - Started NAC and supplements Sept 2007. Doxy and Roxy full dose by Dec '07.  First Flagyl pulse January 2008.  Changed to Tini in December 2008.  Stopped CAP in February 2009 at pulse 16.

 Jim, I had posted a couple of questions, and wanted to make sure that they did not get lost in massive responses.  what is your current medicine regime? which abx are you on right now? what is your schedule in the morning time-re:thyroid meds? do you take a total of 2 or 3 dose of pyruate per day?

Also, I was wondering if the experiment using pyruvate involved MS or nonMs folks, or both? 

Mphs, TN. CFS, hypoT (Hashi), adrenal fatigue, 37 w/hormones of 80,. right arm neuropathy. + cpn, myco, EBV, CMV. NAC 4000mg, doxy 100-2xday, azith 250 m/w/f/sun, progesterone, estriol, synthroid, pulse flagyl, tini<

Mphs, TN. CFS, hypoT (Hashi), adrenal fatigue, hormonal inbalance. right arm neuropathy-getting better. cpn, myco, EBV, CMV, HHV-6. Cap began in 6/07. NAC 2400mg, mino 100mg bid, biaxin 500mg bid. cytomel, flagyl bid continuously.

First happy birthday and second glad to see that things are going well.

Biaxin was the only drug that has ever made me 100 % symptom free. It took away all my facial pain, fibro and it prevented me from developing lupus. I thought I was cured. My dosage was also 500 x 2 a day. Sadly though, I stopped it too soon and all my symptoms came back. Now, heres the thing.. this new protocol presents a dilema for me. I started the cpn protocol with the doxy/azith/metro thinking that it was a better treatment than the biaxin I took in the past, and now its being suggested that biaxin is actually the better treatment of choice now.

So as we can see this is a problem for me because my cpn is definatly biaxin resistant and has been since the late 90's.

The only other option left is the roxy which is not available here so Ill have to get it myself... a little sooner than i expected it seems.

Anyway this is my question regarding the old vs new protocol?

Its suggested we switch to the biaxin protocol but its suggested to take the biaxin at the highest dose which is 500 x 2 per day, but... if we follow the zithro protocol we are suggested to take only the lowest dose at 250 mwf.

 Why is it not instead suggested that we simply up the zithro dose to the maximum instead of switching to biaxin? Did dr S find that many strains of cpn are now zithro resistant or something?

Also, what is the maximum dose of roxy, and what is the dose that is being suggested for this protocol?

Thanks, and to anyone else, if you havnt taken Biaxin before I'd highly reccomend it too.

 

     &nbs

hi Clam. There is nothing wrong with azith in general. The reason is that why DR. S recommended Clarythromycin coz it has a different effect than azith which is needed with the new supplement. (detailed in Jim's protocol blog). Are you 100% sure that you are resistant to it?

doxy200, azith250, NAC 2400, Metro 1250(once a month), supplements, vitamins.

I take the abx twice a day, so it's 6 grams one hour before, twice a day...

But, an additional 6 grams if I'm getting reactions when the abx hit.

Roxy 150mg twice a day. 

I haven't used it but a source of powdered form is:

100% pure Calcium Pyruvate powder, 154 grams per jar.
Produced in Germany.
No fillers, flow agents or preservatives.
$29.95 for 1 jar.
$28.45 for 2-5 jars
$26.95 for 6+ jars.
 

City Pharmacy
701A S. Thompson
Springdale, AR 72764
Phone:  479-751-2072
Fax:      479-751-2341

CAP for Cpn 11/04. Dx: 25yrs CFS & FMS. Protocol: 200mg Doxy, 300mg Roxithromycin, Tini 1000mg/day pulses; Vit D1000 units, Iodoral 50mg, T4 & T3

Jim, Thanks so much for sharing these links. Locally I have been paying $16.19 for 90 tablets of the NOW brand Pyruvate 1000 mg.

I want to check out their prices on our other supplements too. Louise

CFS/ME.CPnPositive.BbPositive.WheldonCAPbegan6/24/07. NowNAC,Doxy, Roxi, Full TiniPulses. Cholestyramine at BedtimeforPhorphoria&liposacarideEndotoxinDie-OffExperiences.

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

thanks too.  we pay a fortune for vits and supplements in the UK (£21 i.e. $40 dollars for the same here calcium pyruvate; and Emergen Vitamin C about £15 i.e. $30 dollars, even on-line!). of course we have to pay postage and customs taxes on top, but still probably worth it!

M.E./CFS 20 years, intermittent.  Wheldon Protocol - Started NAC and supplements Sept 2007. Doxy and Roxy full dose by Dec '07.  First Flagyl pulse January 2008.

M.E./CFS 20 years, intermittent.  Wheldon Protocol - Started NAC and supplements Sept 2007. Doxy and Roxy full dose by Dec '07.  First Flagyl pulse January 2008.  Changed to Tini in December 2008.  Stopped CAP in February 2009 at pulse 16.

It is still definately worth it, no probably about it...

Happy Birthday Jim,

Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse. Zoo keeper for Ella, RRMS, At worse EDSS 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse.

Happy birthday Jim, hero and poster child of cpnhelp, thank you for all the good work you do, wishing you many more trail-blazing years to come.

Elinor ..... from England  on CAP, doxy/roxi/tini  for ME/CFS/lyme borreliosis, positive Cpn and borrelia. Started Aug05, stopped Jan06, started again Sept 06.

Elinor ..... from England  on CAP, doxy/roxi/tini  for ME/CFS/lyme borreliosis, positive Cpn and borrelia. Started Aug05, stopped Jan06, started again Sept 06.

Happy birthday, and may each coming birthday be happier and happier.

Combined Antibiotic Protocol minocycline, azithromycin, metronidazole for muscle pain, insomnia, interstitial cystitis, sinus, disphonia, dry eyes, stiff neck, veins, thyroid, TMJ.

minocycline, azithromycine, metronidazole 2007-2009, chelation for lead poisoning, muscle pain, insomnia, interstitial cystitis (almost well), sinus, dry eyes, stiff neck, veins, hypothyroid, TMJ, hip joints (no longer hurt)

Jim - Happy Birthday !  Wow - What a life ! 

Thanks for all that you do here to help so many including me and my husband.  You are a gentleman, a scholar and a true gem of a human being ! 

Daisy - Husband on CAP 5/07.   Roxy, Diflucan round three 4-4, Rifampin, Bactrim DS, Mepron 4-6, Prednisone, Novantrone, Doxy, Azithromycin, Flagyl, Mino

Daisy - Husband on CAP 5/07.  Husband died from Acute Myelogenous Leukemia Secondary to the Infusion of Novantrone.  Ie - the treatment with the conventional MS drugs killed him. Daisy on her own CAP 11/2012. 

Jim,  Happy Birthday, Yoda!  You've done a terrific job explaining the pyruvate-aided approach to the protocol.  Once again, thanks for testing the waters, jumping in, and dragging in the crowd. 

Joyce~caregiver-advocate in Dallas for Steve J (SPMS).  CAP since August 06, Cpn, Mpn, B. burgdorferi, systemic candidiasis, EBV, CMV & other herpes family viral infections, elevated heavy metals, gluten+casein sensitivity. 

Joyce~caregiver-advocate in Dallas for Steve J (SPMS).  CAP since August 06, Cpn, Mpn, B. burgdorferi, systemic candidiasis, EBV, CMV & other herpes family viral infections, elevated heavy metals, gluten+casein sensitivity. 

 Again, thanks to all for your well wishes and your appreciations. We have such a great community of folks here, and I'm exceedigly grateful for all of you and what we have done together. 

CAP for Cpn 11/04. Dx: 25yrs CFS & FMS. Protocol: 200mg Doxy, 300mg Roxithromycin, Tini 1000mg/day pulses; Vit D1000 units, Iodoral 50mg, T4 & T3

Hi Jim ! You wrote that you switched from Biaxin to roxy to azith. i am thinking to switch back from biaxin to azith - because of my urticaria/rash. And I think azith is less potent than biaxin. What about resistance when switching in the macrolide group?

something to worry about?

Male 38 years (Germany),CFIDS, IBS, Enterovirus, Cpn and Bartonella, Dientamoeba fragilis positive. Started Cap on 02/19/08, Currently taking Bactrim, Flagyl, soon adding Malarone and Clindamycin for suspected protozooa.