Fasting and Flagyl
... After two weeks of doxycycline if all went well, I'd add metronidazole 500mg twice a day with 6 grams of pyruvate before that. ...No rationale for this was stated; but one could suppose, for instance, that the doxycycline and azithromycin that the patient would be on, at that stage of the protocol, would be enough to suppress the germ into a state where metronidazole could kill it, and that pyruvate might provide energy that somehow helped in the killing process.
In any case, that was what I experimented with first: just adding metronidazole, without changing the food part of my regimen, which consisted, at that point, of twice a day eating a sugar-rich meal (half an hour after taking antibiotics; the purpose of this, as detailed in the last report, was to draw the germs out, by feeding them at the same time as the antibiotics reached their highest level.) For comparison purposes, I varied that by sometimes eating in a normal healthy way (more meals per day, without all the sugar). In both cases I took metronidazole 500 mg twice a day, at the same time as the other antibiotics. (Which at this stage, are minocycline 100 mg bid, azithromycin 250 mg every other day, rifampin 300 mg bid, and niacin 1 g bid.)
The results seemed, at first, to back up Stratton's original recommendation: I got more die-off (or at least felt worse) on the sugar-rich days. But the difference wasn't huge, and after a while, I started to wonder. For one thing, it seemed like I was feeling the most die-off during the times of day when I was hungriest -- and those times occurred a lot more on the two-meals-a-day sugar-rich strategy, since before eating those big sugary meals, I'd wait until I was rather hungry, so that it'd be easy to stomach them. On the sensible-eating strategy, I didn't let myself get nearly as hungry before eating. Could it be that I had it backwards, and that the simple reasoning I'd started with was correct, and that it was the getting hungry, and being hungry during the half hour after antibiotics but before eating, which was giving me the increased die-off? Could it be that I should starve the germ into the cryptic state to enhance the effect of Flagyl? If so, well -- if just a half hour of hunger plus Flagyl plus the other antibiotics gave me noticeable die-off, then what would a whole day of hunger plus the antibiotics give me? It'd have to be an enormous response.
It was. My oh my, was it. I haven't felt so bad at any time during the protocol. Just one day of fasting, taking the antibiotics twice during that day, and I was feeling very sick indeed. Not only did I not feel like eating, I had trouble even keeping the antibiotics down. Even the next day, I felt a bit woozy. There was no question of taking more Flagyl; I took a few days to recover just from that one-day pulse.
Of course, one can always get sick for various random other reasons -- a passing virus, or something -- so to make sure, I repeated the experiment. The second time, my reaction was still very strong, but enough milder that I could, at the very end of the day, eat a meal just before going to bed; by that time I no longer felt like I'd sick it up. The third time, the reaction was reduced still further, and I could eat earlier. The fourth time, it was mild enough that I felt hungry most of the day; after eating late in the day, I repeated the fasting and Flagyl the next day. But those two days were enough: now I'm resting from them (and catching up on my eating).
This strong but quickly-diminishing response is very encouraging: it suggests that I've hit on the way to quickly get rid of the rest of my infection. But it deserves a big fat red warning: Danger! Don't just jump in and try all this at once! Work up to it slowly. I've been taking antibiotics for years, and have very substantially whittled down my infection level; I probably got rid of upwards of 90 percent of it before I tried this fasting trick. If I'd tried all this at once, at the very start, my reaction, perhaps ten or twenty times as strong, might have seriously injured or even killed me. Besides, your mileage may vary; I've just run a one-rat experiment here, nothing definitive.
Still, I can't help speculating that the variations in response between different people that we've seen on this forum may very largely have been due to their eating habits. I recall Rica, for instance, posting of having gone hungry a lot, due to the need to space out medications and charcoal; and on the whole she has done quite well. This dependence on state of hunger might also explain a lot of the variation from pulse to pulse that people have experienced.