Failure to join the dots yet again!

Doxycycline Could Enhance Interferon Beta 1-a (Avonex) Therapy in Remitting Relapsing MSi: Presented at ECTRIMS

By Bruce Sylvester

THESSALONIKI, GREECE -- October 4, 2005 -- Interim findings from an ongoing study suggest that the addition of oral doxycycline to interferon beta 1-a (Avonex) therapy for patients with relapsing remitting multiple sclerosis (RRMSi) results in statistically significant reduction of gadolinium enhancing (Gd+) lesions compared to interferon beta 1-a monotherapy. "We saw a great reduction in gadolinium enhancing lesions over the period of 4 months after we introduced oral doxycycline to interferon treatment with Avonex.....................We are hopeful that this combination treatment will prove to greatly reduce relapse rates among these patients, who are all relapsing remitting patients," said investigator Rhonda Brooks, Clinical Research Coordinator, Louisiana State University Medical Center, Baton Rouge, Louisiana, United States.

A slight failure to join all the dots, methinks.


These scientists are so sold on the autoimmune story of MSi that they probably see the doxyi as working because of it's anti-inflamatory effects, not it's antibiotic ones. This is precisely why Sriram and Stratton et al did that last study, using rifampin (300 mg twice daily) and azithromycin (500 mg every other day) to prove that it wasn't the anti-inflamatory effect which made the difference as these abxi don't have any anti-inflam effect. It made for a less effective treatment as it wasn't the full protocol, but was a necessary link to fill in the scientific dots for those who need braille to read what's in front of them. 

On Wheldon protocol for Cpni in CFSi/FMSi since December 2004.


CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Sarah/Jim - Part of the reason I have decided to do antibiotics (abxi for those of you just picking up the abbreviations) alone is just this type of logic!

 I do NOT want some neurologist or wannabe deciding it was not the abxi which helped me, but rather the Copaxone they keep trying to force on me.  I don't want anything muddying up the picture or giving the uninitiated the wrong idea.   This way, if I give them 'dots' the size of baseballs to connect, maybe they'll see the big picture. (And thanks, Jim; I had been wondering why they chose those drugs specifically and now I know.)

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems.  Mohandas Gandhi

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

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