Antimicrob Agents Chemother. 2005 Sep;49(9):3959-62.Click here to read Click here to read Links
Effect of simvastatin, an established lipid-lowering drug, on pulmonary Chlamydia pneumoniae infection in mice.
* Erkkila L,
* Jauhiainen M,
* Laitinen K,
* Haasio K,
* Tiirola T,
* Saikku P,
* Leinonen M.
National Public Health Institute, Department of Viral Diseases and Immunology, P.O. Box 310, 90101 Oulu, Finland. email@example.com
The effects of simvastatin treatment on Chlamydia pneumoniae lung infection, inflammation, and serum lipids in mouse model were studied. Simvastatin decreased viable chlamydial counts and increased inflammatory cell infiltrates in the lung tissue, suggesting that simvastatin treatment had both antichlamydial and immunomodulatory effects during an acute C. pneumoniae infection.
PMID: 16127082 [PubMed - indexed for MEDLINE]
This is interesting if considered as there is a considerable amount of information suggesting the statins may be of help in many inflammatory conditions. Atherosclerosis is both frequently associated with CPn and positvely affected by statins while in the field of MS statins are just beginning to show promise and we also have early evidence that infection is likewise possibly causing the inflammation.