Submitted by mrhodes40 on Sun, 2007-04-08 16:10

Antimicrob Agents Chemother. 2005 Sep;49(9):3959-62.Click here to read Click here to read Links
Effect of simvastatin, an established lipid-lowering drug, on pulmonary Chlamydia pneumoniae infection in mice.

* Erkkila L,
* Jauhiainen M,
* Laitinen K,
* Haasio K,
* Tiirola T,
* Saikku P,
* Leinonen M.

National Public Health Institute, Department of Viral Diseases and Immunology, P.O. Box 310, 90101 Oulu, Finland. leena.erkkila@ktl.fi

The effects of simvastatin treatment on Chlamydia pneumoniae lung infection, inflammation, and serum lipids in mouse model were studied. Simvastatin decreased viable chlamydial counts and increased inflammatory cell infiltrates in the lung tissue, suggesting that simvastatin treatment had both antichlamydial and immunomodulatory effects during an acute C. pneumoniae infection.

PMID: 16127082 [PubMed - indexed for MEDLINE]

This is interesting if considered as there is a considerable amount of information suggesting the statins may be of help in many inflammatory conditions. Atherosclerosis is both frequently associated with CPn and positvely affected by statins while in the field of MS statins are just beginning to show promise and we also have early evidence that infection is likewise possibly causing the inflammation.

Comments

This is interesting reading, even though it does not give us any definite answers in the case of a chronic infection, this evidence together with the empirical evidence would suggest that statins have a beneficial effect in the treatment of Cpn.   I include the link here, as it seems to have disappeared from Marie's post.Thanks Marie for all this new and updated information you have posted. Michele: Wheldon CAP1st May 2006 for ailments including IBS, sinusitis, alopecia, asthma, peripheral neuropathy. Spokesperson for Ella started Wheldon CAP 16th March 2006 for RRMS. Sussex UK

Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse.