Effect of Hydrocortisone Succinate on Growth of Chlamydia pneumoniae In Vitro

NAOKI TSUMURA,1,2 UMIT EMRE,1 PATRICIA ROBLIN,1 AND
MARGARET R. HAMMERSCHLAG1*


State University of New York Health Science Center at Brooklyn, Brooklyn, New York,1
and Kurume University School of Medicine, Kurume, Japan2
Received 23 February 1996/Returned for modification 16 April 1996/Accepted 8 July 1996
We examined the effect of hydrocortisone succinate on the growth of three isolates of Chlamydia pneumoniae
in vitro. There was a significant increase in the number of inclusions seen in two of the C. pneumoniae strains
in the presence of hydrocortisone. There was no significant increase in the number of inclusions with various
concentrations of hydrocortisone over time. The addition of hydrocortisone did not affect the in vitro activities
of azithromycin, erythromycin, and doxycycline against C. pneumoniae.

Link: 

JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

Jim,  I've been re-reading this Article.  When you, or someone else has a moment could you interpret please.  I believe it DOES indicate that hydrocortisone increases the levels of CPN.

I need to understand this as I am again experiencing severe bronchial issues after backing down to the protocol's normal doses (doxy 100 mg BID, Azith  250 M/W/F).  I am hitting the Tini today to see if I can get this in control.

Thank you so much!

JeanneRoz

JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

Jeanne, perhaps you might ask your doctor for some immune function tests. I know I came down with a nasty respiratory infection the second year of my treatment for Cpn. It turned out it happened right after my orthopedic doc gave me a big dose cortisone (into the joint area) for a torn rotator cuff. I also found out from my Cpn doctor that my white cell count was also very low at this point.No wonder I was having trouble fighting this lung infection.

Some things you might consider to boost the immune system would be a mushroom mix like Source Naturals Mushroom Immune Defense:

http://www.iherb.com/ProductDetails.aspx?pid=1472&at=0

I also like Olive Leaf Extract for immune support. Also, Allicin is great for viruses and bacterial infections.

My thoughts about this immune weakness is that my white cells were ravaged by Cpn infection and dying off with the CAP. The macrophages are slowed down and disabled by Cpn.

A few months later in May '06 I began to take Low Dose Naltraxone. I highly reccommend it. It helps increase Natural Killer cell production by increasing endorphins. You may want to look into it.

Immune function can be helped by getting lots of quality sleep and getting some exercise if you can handle it.

Good luck and let us know how you are doing,

Raven

Feeling 98% well-going for 100. Very low test for Cpn. CAP since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NAC,BHRT, MethyB12 FIR Sauna. 1-18-11 begin new treatment plan with naturopath

Hydrocortisone increases number of inclusions inside the cells, which leads to persistence of the bacteria. Presence of the hydrocortisone does not affect activity of azithromycin, erythromycin and doxycycline.

Cured of multiple sclerosis, stopped the Wheldon's protocol in Nov,2008. Use only LDN.

Thanks Jim and lifeonice, I just wanted to confirm my understanding of the article.  I appreciate you taking the time to answer me.

At my appt. last month, My dr. did not "think" hydrocortisone would have this affect  (I will run this article by him). He believed I had "caught something else.   I have not had much progession over the last 5 months and keep getting this severe bronchitis back, so it's time to do some further investigating. 

Raven, thank you for your suggestions.  Actually my doc had mentioned LDN a few months ago, so will bring it up again.  But may also discuss titrating down on the hydrocortisone.  I have never been able to take mushroom supplements -- it tested as an allergen on my Elisa test and made me feel like I had the flu.

Definitely am inquiring about immune funtion testing.

JeanneRoz

 

 

JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

Jeanne- This is a confusing issue, as there are a range of findings. The study you cite does indeed say that cortisone increases chlamydial growth:

…The results of the present study demonstrated that the ad-
dition of steroids enhanced the growth of two of three strains
of C. pneumoniae in HEp-2 cells. No dose-response effect was
observed. It is interesting that even the presence of fairly low
concentrations of hydrocortisone succinate seemed to signifi-
cantly enhance the growth of C. pneumoniae TW-183 and
BAL-14 in HEp-2 cells. The highest titers of C. pneumoniae
TW-183 were seen with 0.25g of hydrocortisone succinate
per ml, which is considerably lower than the recommended
level in serum (1 to 1.5

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Hi JeanneRoz and Jim. One afternoon in early 1999 I was sitting in the UCSD Biomedical Library trying to figure out why I had had a heart attack a few months earlier. I stumbled onto the paper by Tsumura et al. and learned a new word: hydrocortisone. Within a couple of hours I learned:

  • Hydrocortisone is a synthetic version of the stress hormone cortisol
  • Infections raise cortisol levels
  • Cortisol suppresses the immune system
  • Cortisol causes a disease called Cushing's syndrome
  • Most people with Cushing's syndrome die of heart disease

The Tsumura paper changed my life--I've been studying and writing about infections and cortisol ever since that afternoon. I have read thousands of abstracts and papers since then, but I don't think I ever read the Tsumura paper again. That's a shame, because I didn't know enough to appreciate it in 1999.

Jim quoted a portion of the paper that said: "The highest titers of C. pneumoniae TW-183 were seen with 0.25ug of hydrocortisone succinate per ml, which is considerably lower than the recommended level in serum (1 to 1.5ug/ml) for the treatment of asthma."

This is confusing to me because the NIH reference range for cortisol levels is 5 to 25 ug/ml. Another small mystery to solve.

Thanks to both of you for finding and discussing this paper. Russ

COPD, CHF, atrial fibrillations. Diagnosed with CPN in 1999, but can't get HMO to take it seriously. Website is www.potbellysyndrome.com

Raven, I too am consideringLDN, I have read that it may support my liver in healing the reaction that it is having to CAP medications in my system (in this reaction, I am in the minority, that is good to know for most other folks here!)   I have read that LDNhas been demonstrated (not proven of course)to decrease liver enzymes as well as many other beneficial effects. It is good to read as much as possible before considering it, of course. I have read it in your signature line and have wondered about your reasons for using it.  I posted the link to the 2008LDN conference a short time ago.

JeanneRoz, you have some good feedback to consider here!

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support