MediTest
Submitted by Jim K on Sat, 2006-09-30 18:26

Our dear friends and stalwart researcher/clinicians, David Wheldon and Charles Stratton, have published a superb editorial review of the evidence arguing against the autoimmune response as the causal factor in Multiple Sclerosis, and examining the evidence for Cpn involvement in said disease. This was evidently at the request of the journal's editor, who see's their thinking in this as worthy of wider review. Congratulations Dr. Wheldon and Dr. Stratton! A real coup to have this published in a peer reviewed medical journal.You can see Marie Rhodes commentary on this publication at http://www.thisisms.com/ftopicp-19094.htmlTrends Microbiol. 2006 Sep 21; [Epub ahead of print]Multiple sclerosis: an infectious syndrome involving Chlamydophila pneumoniae.Stratton CW, Wheldon DB.Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.The concept of autoimmune myelinopathy as the primary pathology in multiple sclerosis (MS) is problematic. Vasculitis is seen in the MS brain, both within lesions and in adjacent normal-appearing white matter. The first observation in acute relapse is the sudden, orderly death of oligodendrocytes; inflammatory removal of unsupported myelin seems to be a secondary process. An alternative explanation for these findings is that oligodendrocyte infection might trigger an inflammatory response. Many pathogens, including Chlamydophila (Chlamydia) pneumoniae, have been associated with MS. MS might be an infectious syndrome in which C. pneumoniae has a role in a subset of patients. Mechanisms by which such a cryptic infection could engender relapsing-remitting and, ultimately, progressive disease patterns are discussed.PMID: 16996738 [PubMed - as supplied by publisher]  

Comments

let me add my congratulations as well! Way to go Guys! And lucky for us we get to be on the cutting edge of it here at CPnhelp.org. I am so grateful to these compassionate men for caring enough to share their understanding with people who have MS today so that they need not wait for others to get on board before thye can try it for themselves. I have said it before but really every one of us must do a trial on ourselves to see if what we have been prescribed works for us. If your neuro wants you on copaxone, you still have to try it on YOU to see if it works in your case. Sometimes people find it does, but all too often in MS, people have disappointing results with these approved drugs. To me there is not the much difference between that and trying antibiotic protocols to see if that will work for you. With the addition of this paper, we have peer review and validation of the plausibility of the theory, making it an even more tempting proposition .
marie
On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.
"Color out side the lines!"

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

Marie, this is very exciting news!!! Let's hope it becomes a catalyst for a paradigm shift. The mind set of the medical community needs to change. This is such positive news.thanks for posting it,RavenCAP since 8-05 for Cpn and Mycoplasma P. for MS and/or CFS 

Feeling 98% well-going for 100. Very low test for Cpn. CAP since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NAC,BHRT, MethyB12 FIR Sauna. 1-18-11 begin new treatment plan with naturopath

Congratulations! I hope this article will prove to be the "thin end of the wedge" for this idea. By the way, the link I used for Marie's review was http://www.thisisms.com/ftopicp-19094.html The one above gave me a 404 error.RonOn Stratton protocol for CFS starting 01/06 (NE Ohio, USA).

RonOn CAP for CFS starting 01/06 (NE Ohio, USA)Began rifampin trial 1/14/09Currently: on intermittent

Good afternoon, everyone!  I only just looked here because I thought that Marie was going to post the abstract here today, one day later than at ThisisMS.  Thank you Jim, because it seems to have gone singularly un-remarked upon there.  Not for much longer, though:  I can't sit on my hands forever.  And than you, Ron, for getting the link right.  By the way, Jim, you have a mis-placed apostrophe in those Doctors........Sarah  An Itinerary in Light and Shadow  Berger.Started the Wheldon regime in August 2003, due to very aggressive SPMS.  Moved to intermittent therapy after one year.  In 2006 still take this, two weeks every two months.  EDSS was about 7, now less than 2

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

You are right, Sarah. I waited until Marie posted it on ThisIsMS first, and then couldn't wait to get it posted here I was so excited. I'm hoping Marie will provide a more cogent review of the actual paper here, so linked her commentarty at ThisIsMS until it is so. I did jump the gun a bit, but they were first! Apostrophes corrected.Combined Antibiotic Protocol for Chlamydia pneumonia in Chronic Fatigue Syndrome & Fibromyalgia- Currently: 150mg INH, Doxycycline/Zithromycin, Tinidazole pulses. Northern Ohio, USA

I thought so!  Well, the entirely unexcited brigade have woken up at ThisisMS, mentioning no names.  I do dislike people who quote out of context, just to suit their own ends.........Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Great News!  Congratulations - I missed this on the other site.  On Wheldon protocol for MS since April, 2006.  doxy 200 mgs daily, zithromax 250 mgs 3x/ week , LDN 2004

5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tini pulses,100 mg diflucan, 4.5 ldn; Wheldon protocol for MS April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.

Red

Congratulations and many thanks as well to Drs Wheldon and Stratton for all your efforts! On Combined Antibiotic Protocol for Cpn in Rosacea since 01/06

Treatment for Rosacea

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This long awaited contribution is supported by reams of postings from those of us who have taken the "leap of faith" with no regrets, and steady progress towards healthier and fuller lives. Thank you Doctors Stratton and Wheldon.

CAP 2/14/06 for Cpn-CFS/FM/CD

When we discuss "The Others" on the other site it reminds me of the tv show Lost Laughing no pun intended.  On Wheldon protocol for MS since April, 2006.  doxy 200 mgs daily, zithromax 250 mgs 3x/ week , LDN 2004

5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tini pulses,100 mg diflucan, 4.5 ldn; Wheldon protocol for MS April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.

Well, David and I had a competition to see which of us this time would get into print first, because I have a painting being used for the cover of a Dutch architectural magazine, "Bouwfysica" in the next issue:   David has won: http://tinyurl.com/y5ulpe because although my mag is being printed at the end of this month, it is not yet published.  He can buy me a meal at the Saffron next weekWink.......Sarah   An Itinerary in Light and Shadow  Berger. Started the Wheldon regime in August 2003, due to very aggressive SPMS.  Moved to intermittent therapy after one year.  In 2006 still take this, two weeks every two months.  EDSS was about 7, now less than 2

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Congratulations to you both! Raven 

Feeling 98% well-going for 100. Very low test for Cpn. CAP since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NAC,BHRT, MethyB12 FIR Sauna. 1-18-11 begin new treatment plan with naturopath

Sarah, that's great! Are the instruments rendered in acrylics?RonOn Stratton protocol for CFS starting 01/06 (NE Ohio, USA) Currently: doxy & zith -- continous; metronidazole -- 4days on, 7 days off.

RonOn CAP for CFS starting 01/06 (NE Ohio, USA)Began rifampin trial 1/14/09Currently: on intermittent

Congratulations to both of you - that is a very cool magazine cover!  On Wheldon protocol for MS since April, 2006.  doxy 200 mgs daily, zithromax 250 mgs 3x/ week , Flagyl Pulses start end Sept., LDN 2004

5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tini pulses,100 mg diflucan, 4.5 ldn; Wheldon protocol for MS April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.

No, Ron, I can't do it in acrylic yet. That picture is life size and has so many complex layers of glazing.  It was done in oils, but several years ago.  The magazine editor saw it and fell in love with the storm clouds behind as much as the instruments.  I suppose it ought to be me who buys David a meal really, and perhaps I'll give CWS another print.........SarahAn Itinerary in Light and Shadow. Started the Wheldon regime in August 2003, due to very aggressive SPMS.  Moved to intermittent therapy after one year.  In 2006 still take this, two weeks every two months

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

I just finished reading the full-text of the article. Congratulations and thanks, again, Drs. Stratton and Wheldon. For what it's worth, here's my take:It can be ignored, but it cannot be dismissed.Of course, I very much hope that it is accepted out of hand and the course of medical treatment of MS changes immediately.Failing that, I hope that your article ignites an absolute storm of protest; nothing more effective for drawing attention. You may not be the 800-lb gorilla in the room, but you are definitely a good, big wasp. It doesn't seem like a good idea to totally ignore it.Thanks again, Ron On Stratton protocol for CFS starting 01/06 (NE Ohio, USA) Currently: doxy & zith -- continous; metronidazole -- 4days on, 7 days off.

RonOn CAP for CFS starting 01/06 (NE Ohio, USA)Began rifampin trial 1/14/09Currently: on intermittent

Perhaps someone with a copy of the full article should send a copy on to all the possible contacts referenced on this webpage and to recommend to the National MS society that it's time they fund a study of this treatment for MS. A celebrity to help champion the cause and give it visibility could help get things moving if you know of anyone that could be approached for support. http://www.nationalmssociety.org/Highlights-Infection.asp  CFS-2004

CFS-2005 CPN 2500mg NAC daily

Celebrities have been approached, and, as I understand it, a few here have approached others, beyond the three I've contacted.  One has to consider all sides of an approach like this before acting on it, however.IF the celebrity has enough 'clout', broaching the topic might create a groundswell of pressure to move forward with research and treatment (i.e. Oprah).    If a bunch of copies of the paper are sent around scattershot, and some wrong-headed 'celebrity doctors' decide to ridicule the idea, we could find ourselves dealing with a backlash ranging from doctors refusing to prescribe to the government stepping in and trying to deny us and future patients this treatment.  I don't advocate NO action; I just think you have to remember this is a chess game.  Chess isn't played one move at a time, it's played three and five moves ahead.  Being impatient can result in unwanted reactions.  

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Thought I would bump up this Sept. 2006 Forum Topic for those that may find the links and insights informative.  There is a massive amount of interesting reading back here in the archives.  For me the trick is finding a topic then exploring around it!

  • CAP(TiniOnly): 06/07-02/09 for CFS
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I found this article below from 2004 to add to Stratton and Wheldon's of 2006 - and yet they still are barking up the "auto-immune" tree?http://www.newswise.com/articles/view/503335/I know that at one point I also read a scientific report of 2 different autopsies of MS brains, where - not only did they NOT find the beginnings of an auto-immune system attack - but what they did find was CPn.  I am almost 100% positive about that.  I wish I could find that article - it seems like year 2001 rings a bell.Kelly

Diagnosed FMS Feb '07.  2x/day: 600 mg NAC, 100 mg Doxy, 500 mg Amoxicillin, 2000 iu Vit. D.  450 mg Valcyte.  250 mg Azi M/W/F.  500 mg 375 mg Flagyl pulses every 3-4 weeks.  Started CAP June '07. 

Kelly
I think you are thinking of the Barnett and Prineas paper from '04, but they never found CPn in the MS brain. They did however show that the lesion started with death of an oligodendrocyte...the inflammation happens THEN as the second event, just s it should. Did CPn kill the oligo? That's the unanswered question

See the paper here
http://www.direct-ms.org/pdf/ImmunologyMS/Prineas%20new%20lesion.pdf

I am certain there is no MS pathology paper showing CPn. We need it, but it is not out there....YET! marie

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

No - there was another paper, I swear, and it wasn't research done on this one particular young subject, this research was done on two different autopsied brains studied for that paper.  I ran across it about a year ago and have tried a few times to re-find it but without any luck so far.  But I know it's out there somewhere!Kelly 

Diagnosed FMS Feb '07.  2x/day: 600 mg NAC, 100 mg Doxy, 500 mg Amoxicillin, 2000 iu Vit. D.  450 mg Valcyte.  250 mg Azi M/W/F.  500 mg 375 mg Flagyl pulses every 3-4 weeks.  Started CAP June '07.