Dr Martin Pall and the NO/ONOO theory
I recently discovered the work of Dr Martin Pall and am wondering why nobody has discussed it here much due to the fact his theory could be part of the whole CPN dillemma. I have read some of his work, along with DR Paul Cheney's work and think it is truly amazing. I find it to be a potentially huge break through in my mind. I would like to hear why others believe his theory or disbelieve it.
So I'm posting a link here for people to look at and hopefully will give this serious consideration as it may relate to CPN. http://thetenthparadigm.org/ Novel Disease Paradigm Produces Explanations for a Whole Group of Illnesses
I can say personally that I have experienced the effects of Nitric oxide in my body from Caffine, provigil, Horny goat weed, Arginine, maybe wellbutrin. They all seem to have the same effect on me where I get spacy, wired, and weird.
I have started with some supplements that suppose to "down regulate" the Nitric oxide, or scavenger the peroxynitrite and am impressed with the improvement in symptoms of fatigue and anxiety, etc.... Anybody else belive in this stuff?? I'm really excited about it.
One of the things some find most amazing is in Dr cheneys work he mentions that people with CFS have low Uric acid levels, lower than he has ever seen. he also mentions that Uric acid offsets peroxynitrite. (Peroxynitrite causes cell damage.) He also mentions that he has never seen somebody with gout have MS at the same time. (gout is created from excessive Uric acid) So the take away is maybe Uric acid could provide protection from MS? I'm going from my terrible memory, so please confirm.
ANother thing. the Peroxynitrite can affect NK cell activity? THere is a lot of good info in those two links if you folks take the time to read them.
He has explainations for all them major problems. like depression, anxiety, NK cell function, elevated cytokines, mitochondrial disfunction.
Have a look. it's good stuff but very technical.