Does doxy need to be taken twice a day?

Currently, I take 100mg Doxy and 250 mg Azith in the morning.  Then I take another 100mg Doxy in the evening.  I'd like to take the two 100mgs of Doxy in the morning.  Then I could take the probiotics with lunch and not have to worry about things again until the next morning.  Any experience on one dose of abx in the AM vs split doses?  (Ultimately, I suppose it is a question of how long it takes the body to eliminate Doxy.)

Sarah took her doxy once a day... Never did her any harm...

Michele (UK) GFA: Wheldon CAP1st May 2006 . Daily Doxy, Azi MWF, Flagyl at 400mg for 7 days prior to 5 day pulses at 1200mg three weeks cycle. Spokesperson for Ella, RRMS Wheldon CAP 16th March 2006

Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse.

Red

Hi Tom,

You can take the doxy all at once during the day to better fit your schedule if it doesn't cause any gastric problems, etc for you.    Many of us are.   Here's a great thread on the subject:

http://www.cpnhelp.org/doxy_once_or_twice_a_day

I actually had to move my antibiotics (doxy and azith) to take with a larger meal (dinner) as they were a bit harsh on my stomach in the morning , but as Mark says, just find a schedule that works best for you and stick to it.   This is really the important thing...

Hang in there, and keep us posted on your progress....

 

On Combined Antibiotic Protocol for Cpn in Rosacea since 01/06

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

Thanks Red!  I suspected there might already be a thread on the topic but after a few days of not finding it, I decided I could use some help.  I have read the discussion and this is just the info that I needed.  I'll give it a try this weekend.

Tom Vincent, Jr

CFS/ME, Chem Sns.  Colorado.  Start Doxycyclin 200mg (100 AM, 100 PM) on 6/5/07, found CpnHelp site 6/6/07, add NAC 600mg AM & PM (already on most other supplements).  Add Azith @ 250mg AM 6/17/07

Tom~West USA. CFS/ME, Chem Sns., ADD. Adderall, Doxycyclin 2x100mg since 6/5/07, found CpnHelp site 6/6/07, add NAC 600mg AM & PM (already on most other supplements). Azith @ 250mg since 6/17/07

I think most of us started by taking doxy twice a day, but that's usually out of fear of negative response when you first begin the protocol. I know I went to scarfing both pills down together in the mornings within the first week. I took azith at night (yes, I started it at the same time). I've had minor nausea two or three times in a year and eight months, each time because I hadn't eaten anything at all that day. Each one of has to find our own routine.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems.  Mohandas Gandhi

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

 Doxy is better to take twice a day because of its length of action in your system is about 12 hours. In this case taking twice as much then having not enough half the day is not the same, even if many people do do it. In my opinion its a bad idea because you are basically overdosing yourself and then underdosing yourself everyday.

 Zithromax on the other hand can be taken once a day without any problem because its duration is more like 24 hours.

 Talk to your doctor.

CAP- doxy and zithro - fibromyalgia, endometriosis, b12 deficiency

CAP- zithro, flagyl, plaquenil - CPN +, fibromyalgia, endometriosis, b12 deficiency

Okay, this is purely anecdotal but after three days of taking it all in the AM, I do not seem to be tolerating it well (like Jim K and like Jim, I am multiple chemical sensitive).  Also, I feel like my lungs are not as clear.  So tomorrow I am going back to the AM/PM schedule.  Although based on the other information posted here, I'm probably fine taking it at 8AM and 5PM.  So I can have dinner a little earlier which was my initial goal.

Tom Vincent, Jr

CFS/ME, Chem Sns., ADD  Colo. USA  Adderall, Doxycyclin 200mg since 6/5/07, found CpnHelp site 6/6/07, add NAC 600mg AM & PM (already on most other supplements). Azith @ 250mg since 6/17/07

Tom~West USA. CFS/ME, Chem Sns., ADD. Adderall, Doxycyclin 2x100mg since 6/5/07, found CpnHelp site 6/6/07, add NAC 600mg AM & PM (already on most other supplements). Azith @ 250mg since 6/17/07

Red

Hi Manycatz,

I'm certainly no expert (maybe Mark will chime in here), but I believe doxycycline has a half life of closer to 18 hours (while many sites mention 18-22 hours):

http://www.pharmgkb.org/do/serve?objId=340&objCls=DrugProperties

Azithromycin on the other hand has a half life of 2-4 days:

http://www.pharmgkb.org/do/serve?objId=626&objCls=DrugProperties

Also doxy and azith work synergistically when combined. From this page:

http://www.cpnhelp.org/wheldon

"Wheldon Regime

Why doxycyclinei and roxithromycini (or azithromycini)?

Both are oral, both are active against Chlamydia pneumoniae, both are relatively inexpensive. They are relatively risk-free. They act synergically against test strains of the organism; giving both together would be the equivalent of giving a four-fold increase of each drug were it to be given alone."

And also from the above link, Dr Wheldon mentions taking them as follows:

"What might a schedule of treatment comprise?

Antimicrobials
Doxycycline
200mg once daily with plenty of water.
Roxithromycin 150mg twice daily or Azithromycin 250mg three times a week."

On Combined Antibiotic Protocol for Cpn in Rosacea since 01/06

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-
D W

I don't think it matters much whether you take doxycycline once or twice a day. Intracellular concentration is key, and intracellular half-life is much longer than serum half-life. Intracellular concentrations depend very much on the cell type. Some antibiotics are actively taken up by cells, and this may be very important here. One such is roxithromycin, which apparently achieves concentrations in neutrophil leucocytes 30 times greater than in extracellular fluid. [Hand WL, et al., Entry of roxithromycin (RU 965), imipenem, cefotaxime, trimethoprim, and metronidazole into human polymorphonuclear leukocytes. Antimicrob Agents Chemother. 1987 Oct;31 (10): 1553-7. ] Even more importantly, the macrolide class is concentrated greatly in macrophage phagolysosomes - truly an Erlichian 'magic bullet'.

D W - [Myalgia and hypertension (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazole. Now on intermittent treatment. Normotensive; no antihypertensives. BP this am (29th June) 112/75. Even now I can hardly believe this.]

D W - [Myalgia and hypertension (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazole. No medication now. Morning BP typically 110/75]

 half life x 5 says the pharmacist (my doc says x4) is how long the drug takes to entirely leave your system and for doxy the half life is at most 12 hours.  In half life context smoking marijuana would have a half life of something like 10 days.

 For severe infections such as pneumonia the dose is twice daily.

 There is a long acting form of doxy apparently and perhaps if one wants to take it once a day this should be looked for.

  Most of us hate twice a day dosing, but thats how the doctors prescribe it for a reason. I dont think we should be enouraging people to do otherwise. On top of that my doctors a smart man very educated about this and other infections, he ok'd me to take zithro once a day, not doxy.

CAP- doxy and zithro - fibromyalgia, endometriosis, b12 deficiency PCR+CPN

CAP- zithro, flagyl, plaquenil - CPN +, fibromyalgia, endometriosis, b12 deficiency

This is off immed.org, whom I would defer to about anything on this subject. There is a ton more info there under treatment considerations. 

Doxycycline is a broad-spectrum tetracycline with good lipid solubility and ability to penetrate the blood-brain-barrier. This antibiotic acts by inhibiting microorganism protein synthesis; it is readily absorbed by the (normal) gut,

and peak blood concentrations are maintained between 2-18 hrs (half-life, 18-22 hrs)

after an oral dose of drug. Food, calcium, magnesium, antacids and some drugs reduce absorption, and alcohol, phenytoin [Dilantin] or barbiturates reduce blood half-life or suppress the immune system.

For bacterial infections associated with chronic illnesses, the recommended oral dose is 200-300 mg/day (2-3X 100 mg capsules, 2 in the morning) for 6 months. After 6 months, 6 wk cycles are suggested (2-wk in-between).

Azithromycin is a azalide (macrolide) antibiotic with good absorption and a serum half-life of ~68 hrs. This class of drug acts by binding to the 50S ribosomal subunit of susceptible organisms where it interferes with protein synthesis. Food decreases absorption rate, but absorption is unaffected by antacids containing magnesium, aluminum or other salts; other drugs may affect absorption (see above).

For GWI/CFS/FMS use, the recommended dose is 500 mg/day (oral, 1-2X 250 mg capsules taken at once) for each 6-wk cycle of therapy.

 So doxy what they call peak blood serum concentration varies quite widely at 2-18 hours. Most of us fall somewhere in the middle surely. This is why its taken twice a day.

CAP- doxy and zithro - fibromyalgia, endometriosis, b12 deficiency

CAP- zithro, flagyl, plaquenil - CPN +, fibromyalgia, endometriosis, b12 deficiency

Hey, David, You're a doctor and I trust you. I think I'll keep taking mine all at once in the morning. I'm a heck of a lot healthier today than before I started abx therapy.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems.  Mohandas Gandhi

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

> After 6 months, 6 wk cycles are suggested (2-wk in-between).

Nicolson is certainly a heavyweight. Long ago, he and Singer proposed the fluid mosaic model of the biological lipid membrane, and for that you may hear his name in intro bio class. He's also one of very few heads in the abx-for-chronic-illness camp who seems to realize that slow metabolism and stress responses can render bacteria nonspecifically tolerant of abx. But I'm not sure why you'd want to cycle off of doxy. Here we generally agree on the preferability of staying on it full-time.

D W

I'm with you, Mack; whack 'em down with plenty of water at breakfast.

Here is the British National Formulary on doxycycline dosage: '200 mg on first day, then 100 mg daily; severe infections (including refractory urinary-tract infections), 200 mg daily.'

The reference to refractory urinary-tract infections is interesting; C. pneumoniae is suspected of having an input into interstitial cystitis.

D W - [Myalgia and hypertension (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazole. Now on intermittent treatment. No antihypertensive medication. BP this am (30th June) 105/75.]

D W - [Myalgia and hypertension (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazole. No medication now. Morning BP typically 110/75]

Doxy needs to be taken regularly -  please read PATIENT INFO - DOXYCYCLINEi for info on doxy (see additional info section in the handbook).  

To answer once or twice a day - take it to suit your lifestyle (abide by the other advice).  I take it once a day with lunch cos that is easy to remember for me and suits my lifestyle.  The main causes of antibiotic failure are people forgetting their medication and wrong diagnosis.  Keeping to a schedule for  years is a big task for CAPers. 

For the techies - Doxy is bound to plasma proteins and also needs to enter cells to enter to act against CPn so it is largely speculation to say what concentration is acheived inside nerve or other cells by different dosing regimes,  I cannot be bothered with further speculation.

So arrange a CAP schedule which abides by the general advice and suits your lifestyle, then stick with it.   ...   Mark.

 
Mark Walker - Oxford, England.

RRMS Nov 91, Dx 97. CFS Jan03. Copaxone + continuous CAP (NAC, Dox, Rox) Feb06 to May 07. Met pulses from Jun06. Intermittent Abx from June 07 onwards.

Mark Walker - Oxford, England.

RRMS Nov 91, Dx 97. CFS Jan03. Copaxone + continuous CAP (NAC, Dox, Rox) Feb06 to May 07. Met pulses from Jun06. Intermittent Abx from June 07 onwards.

Red

Hang in there Tom. The first couple months and then the first few flagyl pulses can be kind of rough. Be sure you understand the secondary porphyria aspect of Cpn to try to help minimize your reactions:

http://www.cpnhelp.org/secondaryporphyria

And remember to go only as fast as you can, remembering that secondary porphyria symptoms can accumulate and get out of hand quickly...

On Combined Antibiotic Protocol for Cpn in Rosacea since 01/06

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

I started taking my entire 200 mg doxy with my evening meal as doxy can be hard on the stomach.  I also thought that if I was going to have alot of reaction to it, that would be best for me to be sleeping.  I have to take quite a cocktail to stay asleep so I thought I would be ok.  Even so, I drifted up from REM when I have some severe pains in my legs for a few nites.

Other than that, it seems to be working for me, more or less.  Unless, someone tells me otherwise I am thinking this is ok???

Blessings All,

 Ruth

 CFIDS/ME, FMS, IBS, EBV, Cpn, Babesia, insomnia (sleep- melatonin, GABA, tarazadone, temazepam, novocyclopine, allergy formula, 2 gm tryptophan), Natural HRT peri-M, NAC 2.5 gm, Doxy 200 mg day pm, Azith 250 mg M/W/Fday

CFIDS/ME, FMS, MCS, IBS, EBV, CMV, Cpn, H1, chronic insomnia, Chronic Lyme, HME, Babesia, Natural HRT-menopause, NAC 2.4 gm,Full CAP 6-2-07, all supplements+Iodorol, Inositol-depression, ultra Chitosan, L lysine Pulse#27 04-19-10 1gm Flagyl/day-5 days<

Tom,  I take my doxy at 10AM and then again at 10PM (or sooner if I go to bed early) This is roughly 12 hours into the half-life... and gives me time to have breakfast and dinner at reasonable times (especially when I sleep late, and take my supplements --  seems to work for me as I couldn't take it all at once either.

Jeanne: Diagnosed 4/2007 w/ CPN.  Also: HHV6, EBV, FM, CFS/ME; prior bronchitis/sinus; IBS, kidney infections; food allergies; hypothyroid (RAI for Graves in 1998) ]; hypoadrenalism/Azith 250, 1x/wk/ 5/27/07- Doxy 100mg/day 6/16/07 started 200mg/day Doxy, supplements  

JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

I hadn't considered using it on that time frame.  Can you attribute any sleep issues to taking the Doxy just before bed?

I do note that the patient info warns to keep upright for at least 1/2 hour after taking it.

Thanks

Tom~West USA. CFS/ME, Chem Sns., ADD. Adderall, Doxycyclin 200mg since 6/5/07, found CpnHelp site 6/6/07, add NAC 600mg AM & PM (already on most other supplements). Azith @ 250mg since 6/17/07

Tom~West USA. CFS/ME, Chem Sns., ADD. Adderall, Doxycyclin 2x100mg since 6/5/07, found CpnHelp site 6/6/07, add NAC 600mg AM & PM (already on most other supplements). Azith @ 250mg since 6/17/07

I never considered it for bedtime because I take the calcium and magnesium then and did not want those to block absorption of the doxy. I simply decided I couldn't find any more times to space out my many pills. I felt like I was drinking GALLONS of water daily just to get 'em down.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems.  Mohandas Gandhi

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

I was taking it twice a day, too, when I began the regime. But, then, pseudo-relapsed severely. Since then, once a day. Have to wonder if it's not one of the factors in why I am now able to tolerate full doses of both the Doxy and Roxi, now. Maybe it wasn't fair of me to be asking my body to deal with so much die-off, while I slept, after taking that second nighttime dose. This way, I can now suck on the B-12 methyl-cobalamin sublinguals, throughout the day, after taking the full doses, which certainly seems to help.  And, especially, because recent blood results indicate pernicious anemia.

 

D W's info on this is fascinating (not to mention, written from his professionally  experienced and knowledgeable perspective) . And, I certainly wish I had been taking it all in one dose from the beginning, as Sarah was, too!  Image removed.

 

--Minai

 

RRMS, diagnosed 2/04. NAC 4/06. Started Wheldon/Stratton regime 8/30/06. Doxycycline, 8/06, Azith, 10/06. Switched to Roxithromycin 11/06. Psuedo relapse/die-off with hospitalization 1/07. Gad-enhanced MRI of brain and spine shows NO NEW DISEASE ACTIVITY Restarted CAP with NAC and Doxy 2/07. LDN 4/07. Stopped NAC, started Roxi, again 5/07. Now on full doses of Doxy and Roxi. USA

What happens if your meds lapse? I took minocycline (following a protocol from Seattle) from last July until the end of the year when I became allergic to it. I had a 2 month hiatus (while I talked my neuro into the CAP) and then started doxycycline, etc. and for the last few days I've taken no meds or supplements at all because of a stomach virus (it would have been an awful (!) waste). I kept to a strict diet of gatorade and saltine crackers. Does it really matter? Anything that was going to stay in would have had to administered intravenously. What's a gal to do? NancyPPMS-misdiagnosed 5 years-diagnosed last spring. Minocycline 7 mos.- resulting bronchitis 5 months. Talked Hopkins neuro. into: HRT (estriol and progesterone as neural protectant re Voskuhl,UCLA).Wheldon CAP 3/2/07 - 200 doxy; azith MWF. Rockville,Md.

PPMS-misdiagnosed 2001-diagnosed 2006. Probably caught cpn in birth canal but it didn't pass BBB until my 40s. Minocycline 7 mos.- resulting bronchitis 5 months.Go to private m.d. out-of-plan. Wheldon CAP 3/2/07 Stopped 12/12; resumed 12/13

Good morning Arttile, I hope you are feeling better today!  Basically, if you have a stomach upset and are likely to throw it all back up, don't even attempt to take any antibiotics.  Just restart when you feel better.  This came from the doctor's mouth when I was similarly afflicted................Sarah   An Itinerary in Light and Shadow   Stratton/Wheldon regime since August 2003, for very aggressive SPMS.  Intermittent therapy after one year. 2007 still take this, now two weeks every three months, but still slowly improving and no exacerbation since starting. EDSS was about 7, now 2.
Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

So here's my response to myself, hindsight being 20-20 and all.

As D W pointed out, the reported absorption time and time to eliminate a preparation (doxycycline in this case) both in the bloodstream and within the cells themselves is an average based on many people.  And when it comes to a particular individual (me) there can be significant variation from the reported averages.  So we can try different schedules and find out for ourselves what works best for each of us. 

In my case, taking two 100mg doses of doxycycline together once a day is not as effective as taking two single doses with 10-14 hours between.   My specific observation is this:  My lungs feel clearer and less congested when I stick to the once every 12 hours protocol.  I can breath much more deeply.  When I take the doubled dose once every 24 hours, my lower lungs feel tight and it is difficult to get air down there.

I did switch to taking the azithromycin with my evening dose of doxycycline and I like that much better.  I feel like I sleep better.

Best Regards,

Tom~West USA. CFS/ME, Chem Sns., ADD. Adderall, Doxycyclin 2x100mg since 6/5/07, found CpnHelp site 6/6/07, add NAC 600mg AM & PM (already on most other supplements). Azith @ 250mg since 6/17/07

Tom~West USA. CFS/ME, Chem Sns., ADD. Adderall, Doxycyclin 2x100mg since 6/5/07, found CpnHelp site 6/6/07, add NAC 600mg AM & PM (already on most other supplements). Azith @ 250mg since 6/17/07

More thoughts on the subject:

 

Please note my comment immediately above.  I did my homework here on the site.  I weighed the risks, made a decision, and acted.  So this is NOT sour grapes but I do feel I need to share my results and add more caution to this discussion.

 

When I first started taking doxycycline on the divided schedule (one in the morning, one in the evening) and one azithromycin, I was seeing and feeling very significant improvements.  My results were so outstanding that I failed to report them here.  I was scared away from doing so because so many people have no response for a long, long time.  Here, the NAC/Doxy/Azith (and no Flagyl) was working great for me.  But, after several months of taking the doxycycline all in the evening along with the azithromycin,  those gains have nearly completely reversed.  I have to come to the conclusion that my bug has devloped resistance to the doxycycline and it is no longer effective.  In as much as it taking doxycycline together with azithromycin is required to make a bateriacidal combination, if the bug becomes resistant to one, it likely is just a matter of time before it also developes resistance to the other.  It seems likely that I will need to explore other antibiotic combinations now.

 

Now, I also made my decision without consulting with my physician.  I did so because he has not signed on to the protocol but has just been humoring me with an experiment.  In the future, I'll consult with him before I make another such change.  The ancient verse about 'he who doctors himself, has a fool for a doctor' is just trying to warn us that we are far too close to the trees to be able to see the forest.   Again, this is NOT sour grapes.  From what I've seen, the folks on this site do do their best to try to include at least some of the forest in the discussions.

 

Best Regards,

 

Tom~West USA. CFS/ME, Chem Sns., ADD. Adderall, Doxycyclin 2x100mg since 6/5/07, found CpnHelp site 6/6/07, add NAC 600mg AM & PM (already on most other supplements). Azith @ 250mg since 6/17/07

Tom~West USA. CFS/ME, Chem Sns., ADD. Adderall, Doxycyclin 2x100mg since 6/5/07, found CpnHelp site 6/6/07, add NAC 600mg AM & PM (already on most other supplements). Azith @ 250mg since 6/17/07

I can't make paragraphs work, guys, so my apologies.

Okay, Tom, let me ask the question. What great recovery did you see and what decline have you seen? Over what period of time?

We ALL have had a 'two steps forward, one back' journey here. I have apparently been one who's had the easiest time of it on the protocol, yet there have been tmes I've said 'this isn't working' because of a perceived backslide or dip in the road.  Operative word: perceived.

I have to tell you, you haven't been doing the protocol long enough to have a handle on what's permanent, what's transient and what's lost or gained. From month two to month four, three people here on the board got me through a similar patch as you're going through. I was 'convinced' it wasn't working anymore because I had something occur that hadn't happened in twenty years. In hindsight, I see that cpn was being KILLED in that location, but it sure scared the stuffing out of me in the moment and I swore I was going to be the ONLY person this protocol didn't help. I was wrong. Patience is what's needed here, and it's a long-term thing.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems.  Mohandas Gandhi

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Mac - I can't make paragraphs work either.  Also it seems all paragraphs have sort of disappeared in some of the responses.  Wierd.  Perhaps it's a delayed CPN-Help Website Flagyl reaction to some deep tissue system repair conducted by it's fearless webmaster Image removed..

Daisy-Caregiver- Balo's Concentric Sclerosis. Began CAP 5/10/07. Doxy 200 mg, Mino 100 BID 9/1/07, AZI 250mg QD 9/10/07, NAC 1800 mg QD, HD Flagyl Pulses, Novantrone, Prednisone & daily lb of supplements.

Daisy - Husband on CAP 5/07.  Husband died from Acute Myelogenous Leukemia Secondary to the Infusion of Novantrone.  Ie - the treatment with the conventional MS drugs killed him.

Daisy on her own CAP 11/2012. 

Hmmm. It DID happen right after Jim gleefully announced he had fixed links and they work now. Jim, are you on a flagyl pulse? Didn't we agree months ago, no site improvements while on flagyl??

Bleu, HELP!

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems.  Mohandas Gandhi

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

The Grand Webmaster is doing magic and housekeeping duties I believe.

I had a wish that I posted somewhere and now well, that page is partially gone.  To return for the better I suspect.

Louise

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Hi Tom,   Thought I would post something that I am pondering regarding your post to day.  I have been reading more about the action of these antibiotics. Have wondered why doxy so far has caused no loose stools and such as the Amoxicillin type group does frequently.  Before pronouning your bugs resistant there may be a few more aspects to consider.  I am going to pass on trying to explain it because I am a tad unsure of my understanding.  I think that in the archives here or it may be on the weldon site there are references and articles concerning the lifecycle CPn.  Take a look around and perhaps someone else will post the links for you so you can feast on the information.  I see that you are one of our CFS identified folks such as myself.  You started several weeks before I did on doxy (6/24/07).

Louise CFS, CPn, Bb(Lyme Borrelia B.), CAP Doxy, NAC, started 6/24/07

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support