Does the Anion Gap cue to Acidosis?

Submitted by MunchMan on Mon, 2011-01-24 09:56

I received my CBC lab results from the LLMD over the weekend, just the CBC not the DNA pathogen test. Everything was still in line of what I’ve seen before. Low lymphs, mild neutropenia, potassium is getting low (maybe explains the cramps). I saw a test I’ve never seen before, Anion Gap. Well I was high, normal top range is 16, and I was a 17.

Researching the information and indications on the test, I came across acidosis/alkalosis. The test provides variant indicators including diabetes, lactic acidosis, metabolic acidosis, and more. In general, I'm thinking the Anion Gap tests for your pH balance. So I did some more digging; yes its possible diabetes or whatever, but I wanted to see about Lyme and bacterial infections with acidosis.

Acidosis, from my sources, is a general symptom of Lyme disease and I speculate other bacterial infections cause the same. An apple cider vinegar regimen can help offset the acidosis and many Lymies use this regimen.

Symptoms for Acidosis include:

* Confusion (can progress to stupor or coma)
* Muscle twitching
* Hand tremor
* Prolonged muscle spasms (tetany)
* Nausea, vomiting
* Numbness or tingling in the face or extremities
* Light-headedness


I have had every one of those symptoms, in the beginning, which had gone away but some have been back in the last two weeks, it seems like my right thigh twitched all day yesterday. I would be interested to see where that level is right now.

I started the apple cider vinegar regimen with Braggs ACV yesterday. You do 2 tsp ACV, 1 tsp raw honey, 1 cup of water, three times a day. The nice thing is this is probably the cheapest regimen I’m doing, around $10 a month. If anything, it should help in other areas as well.

So, can anyone confirm this thought process about the Anion Gap Test and acidosis? I’ve never seen it before and I’m wondering what the doc is looking for.


FWIW, I just had my doc's appointment today and we reviewed, among other things, my CMP, on which was listed the Anion Gap... remembering your post, I asked about what it meant and he confirmed this is a measure of acidicity in the body.  He didn't order it specifically, it was part of the CMP profile. 

The Anion Gap range on my testing was 4-19 with mine at 5.  I started a couple of weeks ago using ph urine testing strips but they are saying I am acidic.

Have you checked out the Wiki definition?




JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

Thanks jeaneroz for confirming this. I thought I was right but wanted to make sure.

Here is some literature supporting reasons why we need to be eating healthy right now adn alkalizing our body.

It is from Amazing Grass, the wheatgrass maker I take. Nice to see some more information on this.


Started CAP on 06/29/2010 for RRMS. Dx w/ Brevundimonas Vesicularis in Jan '11 hiding in #20 tooth with root canal. Extracted 04/04/2011. Clinically dx with Bartonella at the same time. Recently found MPn.

Abx: 100 mg Doxy bid<

When worrying about abnormalities in blood pH (acidosis/alkalosis), the first thing to do is to measure blood pH itself. The 'anion gap' is a secondary measure which might be useful in figuring out the cause of an errant blood pH.

As for the idea that this is a good way to diagnose Lyme (or any other stealth infection), that seems quite improbable. As for drinking apple cider vinegar to remedy acidosis, how on earth is that supposed to work? Vinegar is quite acidic.


I never said Acidosis was a good way to diagnose Lyme; I'm simply hypothesizing that being in an acidosis state can contribute to "stealth infections" and with my research in Lyme, acidosis is a general symptom. That would be silly to assume an acidosis measure can diagnoses Lyme.

Why wouldn't a LLMD look at the pH of the blood first? I can tell you now, it was not run to my knowledge on this last blood test.

Also, you are right about vinegar. It is acidic, quite acidic. But Apple Cider Vinegar is mildly acidic and has other "flavors" that help alkalize your body. I pulled this from to explain.

Foods high in potassium are known to help create an alkaline-forming environment in the blood and urine, according to Dr. Theodore Baroody in "Alkalize or Die." Apple cider vinegar is a weak acid that is very high in potassium and may alter the body's pH when consumed regularly. It is not only helpful for reducing acid reflux, apple cider vinegar can be used as an overall tonic to help prevent disease by reducing acidosis. The easiest way to consume it is by sprinkling it on salads and foods. You can also use it in place of other vinegars in recipes and it can be used as a pickling agent. In addition, you can mix 2 to 4 tbsp. apple cider vinegar in a 6 to 8 oz. glass of water and drink it. If the vinegar is too strong, add more water or reduce the amount of vinegar to a level that you can tolerate. As you get used to it, raise the amount of vinegar to the recommended amount. Drink at least one glass daily.

Read more:

Hope this help explain things.


Started CAP on 06/29/2010 for RRMS. Dx w/ Brevundimonas Vesicularis in Jan '11 hiding in #20 tooth with root canal. Extracted 04/04/2011. Clinically dx with Bartonella at the same time. Recently found MPn.

Abx: 100 mg Doxy bid<

Oh, that's how it's supposed to work. It's not too ridiculous an idea. The acid in vinegar is acid that just gets burned to CO2 and H20, so it isn't hard for the body to get rid of. Potassium, which indeed contributes to alkalinity, has to be excreted in the urine, which is a bit harder. But urinating away excess potassium generally isn't too hard for the body to do either. And the body normally defends its pH level quite vigorously, trying to maintain a constant pH. To have any effect on pH, something you eat or drink would have to overcome all the body's pH defenses, which try to keep the pH at a constant level. And overcoming all those defenses can be quite dangerous.