Submitted by Jim K on Sun, 2005-08-28 20:22

Dehydroepiandrosterone protects mice from endotoxin toxicity and reduces tumor necrosis factor production HD Danenberg, G Alpert, S Lustig and D Ben-Nathan Department of Virology, Israel Institute for Biological Research, Ness- Ziona.

Recent reports have demonstrated an immunomodulating activity of dehydroepiandrosterone (DHEA) different from that described for glucocorticoids. The present study was designed to test DHEA's activity in endotoxic shock and to investigate its effect on endotoxin-induced production of tumor necrosis factor (TNF). Mortality of CD-1 mice exposed to a lethal dose of lipopolysaccharide (LPS; 800 micrograms per mouse) was reduced from 95 to 24% by treatment with a single dose of DHEA, given 5 min before LPS. LPS administration resulted in high levels of TNF, a response that was significantly blocked by DHEA, both in vivo and in vitro. DHEA treatment also reduced LPS-induced increments in serum corticosterone levels, a parameter considered not to be mediated by TNF. In another experimental model, mice sensitized with D-galactosamine, followed by administration of recombinant human TNF, were subjected to 89% mortality rate, which was reduced to 55% in DHEA-treated mice. These data show that DHEA protects mice from endotoxin lethality. The protective effect is probably mediated by reduction of TNF production as well as by effecting both TNF-induced and non-TNF-induced phenomena. This one's an interesting story about a woman who was exposed to a much more lethal LPS than CPn,s is. She used DHEA to ameliorate it.


Ines, thank you for commenting on this. How much DHEA do you take and how often? Do you notice a significant difference?Raven 

Feeling 98% well-going for 100. Very low test for Cpn. CAP since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NAC,BHRT, MethyB12 FIR Sauna. 1-18-11 begin new treatment plan with naturopath

Ines hello! I read your paper some time ago I have it as a favorite! Greetings!
Jim this is an important paper as many studies indicate that DHEA reduces EAE in mice also, so we have another smoking gun that probably has more to do with the impact of immunity on the CNS than it has to do with hormones causing MS.

In other words, the hormone connection to MS has more to do with the fact that hormones influence immunity and thus reaction to things like LPS...not an autoimmune issue or simple "hormone imbalance" that just went too far in a genetically susceptible person

I wonder if DHEA might be effective as a infammation repressor for CAP treatment protocols-I think I may have written DW about this and asked that question some time ago and do not remember the answer, but it is a good idea and I formed it based on Ines paper.
Blessing to you Ines!

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start5.5.
"Color out side the lines!"

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro