MediTest
Red
Submitted by Red on Thu, 2007-12-06 02:03

Hi all, I ran across the following article on a new study today, suggesting that MMP-9 without accompanying TIMP-1, might be very important in cancer angiogenesis:

Scripps Research Scientists Find White Blood Cells Deliver Boost to Tumors; Findings Point to Potential New Cancer Targets

This reminded me of a study I had read earlier about C. pneumoniae's potential involvement in MS which found that infection of microglial cells with C. pneumoniae induced MMP-9 without TIMP-1:

Chlamydia pneumoniae infection of microglial cells in vitro: a model of microbial infection for neurological disease

Note the following quote from the study above:

"As shown in Fig. 4, infection of microglial cells with C. pneumoniae induced MMP-9 mRNA at 24 h after infection but not MMP-2 and TIMP-1, although both were inducible in the cells by treatment with a non-specific stimulator PMA during the infection forup to 72 h. Thus infection of the microglia with C. pneumoniae selectively induced MMP-9, an important MMP implicated in neurological diseases, including MS (Rosenberg, 2002b). However, other MMPs, such as MMP-2, and TIMP-1, which plays a critical role in controlling MMP activity in tissues, were not altered. Control studies showed that heat-killed C. pneumoniae induced minimal, if any, alterations in the level of the MMPs, suggesting that the stimulatory effect was not due merely to active stimulation by some bacterial products such as chlamydial lipopolysaccharide (data not shown). The selective induction of MMP-9 by C. pneumoniae infection in microglial cells revealed in this study is consistent with previous findings that C. pneumoniae infection of human peripheral blood monocytes and mouse peritoneal macrophages induced secretion of MMP-9 (Kol et al., 1998; Rupp et al., 2004; Vehmaan-Kreula et al., 2001), and a selective expression of MMPs, including gelatinase B (MMP-9), was evident in the tissue of MS patients (Bar-Or et al., 1999). In addition, TNF-{alpha} and MMP are thought to have together a critical role in MS pathophysiology, such as damage of the myelin sheath (Bar-Or et al., 1999). Therefore, the marked production of TNF-{alpha} and the selective induction of MMP-9 by C. pneumoniae infection in the microglia in vitro as shown in this study may provide valuable information on the possible involvement of C. pneumoniae infection in neurological diseases such as MS (Sriram et al., 1999)."

Potentially this might be how C. pneumoniae could contribute to the growth of, if not initiate to begin with, cancer?

To be honest, this went 'way over my head'.  So, what I'm about to say may mean the samething. I apologize if it does. My doc says CPN has been linked to breast cancer due to CPN being very inflammatory.  As I have stated in a previous post, I had prophylactic double mastectomies last year for lobular carcinoma insitu (LCIS).  the report from my lumpectomy showed fibrosis, cysts, apocrine metaplasia, ductal ectasia, periductal mastitis, focal intraductal hyperplasia and LCIS. The report also said breast with foreign body inflammatory reaction and fibrocystic changes.  

I'm just in constant awe on how we are at the forefront of all of this. I cant wait for another 10 or 20 years to see how medical community recognizes CPN and it's ramifications.  

Mphs, TN. CFS, hypoT, weak adrenals, 37 w/hormones of 80 yo. right arm neuropathy. 6/26/07- CPN Titer 1:256 (normal 1:16); 6/27/07- NAC; 7/2/07- doxy 100, 2xday; 7/19/07-9/7/07- Biaxin. 9/8/07-azith 250 mg m/w/f. 10/18/07-1st flagyl pulse

Mphs, TN. CFS, hypoT (Hashi), adrenal fatigue, hormonal inbalance. right arm neuropathy-getting better. cpn, myco, EBV, CMV, HHV-6. Cap began in 6/07. NAC 2400mg, mino 100mg bid, biaxin 500mg bid. cytomel, flagyl bid continuously.

 Sharon- Your doc may know of this, but iodine at much higher supplementation than we get in table salt has been significant in preventing and countering cystic breast disease and breast cancer. One summary: http://www.lewrockwell.com/miller/miller20.html .

Red- you may be particularly interested in a quote from that link:

"Iodine also induces apoptosis, programmed cell death. This process is essential to growth and development (fingers form in the fetus by apoptosis of the tissue between them) and for destroying cells that represent a threat to the integrity of the organism, like cancer cells and cells infected with viruses. Human lung cancer cells with genes spliced into them that enhance iodine uptake and utilization undergo apoptosis and shrink when given iodine, both when grown in vitro outside the body and implanted in mice. Its anti-cancer function may well prove to be iodine’s most important extrathyroidal benefit."

 

CAP for Cpn 11/04. Dx: 25yrs CFS & FMS. Protocol: 200mg Doxy, 500mg MWF Azith, Tini 1000mg/day pulses; Vit D1000 units, Cytotec 100mg, Plaquenil 100mg, Magnascent Iodine 12 drps/day, T4 & T3

 another reason to take the iodine supplement. going to gnc this weekend. 

Mphs, TN. CFS, hypoT, weak adrenals, 37 w/hormones of 80 yo. right arm neuropathy. 6/26/07- CPN Titer 1:256 (normal 1:16); 6/27/07- NAC; 7/2/07- doxy 100, 2xday; 7/19/07-9/7/07- Biaxin. 9/8/07-azith 250 mg m/w/f. 10/18/07-1st flagyl pulse

Mphs, TN. CFS, hypoT (Hashi), adrenal fatigue, hormonal inbalance. right arm neuropathy-getting better. cpn, myco, EBV, CMV, HHV-6. Cap began in 6/07. NAC 2400mg, mino 100mg bid, biaxin 500mg bid. cytomel, flagyl bid continuously.

 Sharon- you might look into this a bit more. The most recommended supplement is Iodoral because it is well absorbed and formulated to help avoid stomach distress (which I guess can occur from regular iodine supplements). I take a different form that I've been able to tolerate better. Neither one is available at GNC.

CAP for Cpn 11/04. Dx: 25yrs CFS & FMS. Protocol: 200mg Doxy, 500mg MWF Azith, Tini 1000mg/day pulses; Vit D1000 units, Cytotec 100mg, Plaquenil 100mg, Magnascent Iodine 12 drps/day, T4 & T3