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Both Hammerschlag and Stratton observed in their research that Cpn appeared to rapidly develop resistance against antibiotics. Hammerschlag noted that she searched gene databanks for known resistance genes but found no matches. I also spent a great deal of time searching the Genbank using BLAST and also found no matches to any known resistance genes. Nonetheless apparent resistance is always noted during in vitro experiments with antibiotics. All antibiotics that Cpn are susceptible to cause an initial die off of greater than 90% of Cpn.