Submitted by Jim K on Tue, 2005-08-23 22:21

I believe that Stratton and co-workers used a beta-lactam (penicillin, amoxycillin or similar) to attack the infectious stage
(elementary body) of the organism. They did some in vitro work to support this, which they should publish, because it's
fundamental. I reasoned that, as culture was so rare in persistent human infections, the numbers of elementary bodies would
be small. Also, any elementary body entering a phagosome in a cell containing bacterial protein-synthesis inhibitors would be
doomed, as the organism needs to fabricate proteins immediately to survive. Coupled with this was a native gut-reaction that
people would buy into the idea more readily if there were fewer antibiotics. And, further, that one is taught at med school
never to combine cidal and static agents. In the higher levels of microbiology that's not always true, but basically you just
want people to believe you and treat, as early as possible, and the more complications you put in their way the more difficult
that is.

In fine, I think that mangling the organism and exposing all its components to the immune system for recognition, and purging
the immune cells (lymphocytes, macrophages and monocytes) of the organism is enough. You don't need to kill every last
organism. Just halt bacterial protein synthesis, force the bacterium into a non-oxidative mode, then damage its DNA with
metronidazole while it is unable to repair it. You want a situation like the opening scene of Polanski's Macbeth. After
treatment you might want to keep in with an intermittent maintenance therapy, but to be honest I think clearing the immune
system and exposure of the organism is probably enough.

best wishes,

David

Ms patient with blood test = cpn was present sometimesMy GP put me on MINOCYCLONE 100mg as a start of CAP I am not sure if it's the right option.I am veery confused.