Cpnhelp.org

So tonight I began my online research to battle this bug once more.
I have been following the research of Dr. Russell Reiter who has been researching melatonin for over 50 years. I also follow an independent researcher Doris Loh on Facebook. She has co authored a recent paper on melatonin with Dr. Reiter.
After all the reading I have been doing about melatonin, I decided to enter it into the Google slot machine and low and behold found this paper.
https://pubmed.ncbi.nlm.nih.gov/16172105/
Seems like it’s another weapon against Cpn.

I’ve been ordering it from purebulk.com

Currently taking 60mgs but just bumped it up to 120 mgs and will
be increasing the dose.
Raven

How do you stay awake with that much melatonin?  The ideal dose as a sleeping pill is supposedly 0.3 mg.  Most pills sold are more than that, but still nowhere near 60 or 120 mg.  But the dose supposedly effective against Cpn is... let's see, that paper says 50 µM.  (50 micromolar = 50 micromoles/liter).  With a molecular weight of 232, that's about 11 mg/liter.  So if you figure you might be 50 liters in size, that's 550 mg.

Except it isn't absorbed perfectly: a quick Google gets me "The bioavailability of oral melatonin ranges between 9 and 33% in humans".  So multiply that 550 mg by three if you're feeling lucky or ten if you aren't.

Hi Norman,
Melatonin inducing sleep only happens when the lights go out. And there is an epidemic of light pollution at night since the invention of electric lighting.
No wonder people have sleep issues.
I thought the same thing until I began looking at Russell Reiter’s research.
Initially, I was looking for anticancer supplements for my husband who has prostate cancer. His has spread into lymph glands. He’s being treated with hormone deprivation at the present. And it is currently undetectable.
Melatonin blocks cancer. So I began using it for him. He takes 180 mgs a day.
Being curious, I started looking at more applications.
Turns out there are many. From eye health to blocking viruses.
Take a look on Google Scholar.
Raven

I guess the sleepiness effect must saturate.  (And it's not that big to begin with: small enough that people can deny it.  Certainly on the scale of cancer or of most of the diseases people come here for, a bit of sleepiness hardly registers.)

But looking at the literature on melatonin reminded me of how tired I am of bio papers that don't mention dosages or effect sizes.  When they find a tiny effect at a huge dosage, they haven't actually proven it's useful: exactly the opposite.  But so many papers just blithely say that substance X has effect Y, forcing the reader to go dredge up their sources to find dosages and effect sizes.

Another aspect did pop up, though: the short half-life of melatonin in the body: less than an hour.  So to keep levels high would require not just huge doses but huge doses every hour or so.  (Unless at huge doses things get nonlinear, which is a definite possibility, though that often works against you, as in absorption going down.)  But at least trying seems harmless: there don't seem to be any serious risks.