MediTest
Submitted by Jim K on Sun, 2006-01-08 16:31

Cpn exploits a variety of mechanisms to thwart our immune system. There is one mechanism that is particularly important and can be countered by over the counter supplements. Cpn targets niacin metabolism. In doing so it leads to impaired T-cell function, low melatonin, low serotonin, low tryptophan, low niacin all of which can present as depression, fatigue and insomnia, all familiar symptoms in Chronic Fatigue, Fibromyalgia and a host of Cpn related disorders.

Niacin therapy has been used safely for the treatment of hypercholesterolemia for decades, just the same, niacin levels should be increased slowly to minimize flushing and liver enzymes should be monitored. Expect some endotoxin release (as organisms die) as niacin is increased. Endotoxin release will lower nitric oxide levels temporarily and lead to cold hands and feet and possibly increased muscle aches in the initial stages of niacin treatment. You have to build up gradually on niacin as ingestion causes a flush like a hot flash. This reaction abates as you get used to the increased levels, and you can increase (UP TO???) the dose as tolerance develops.

Eventually time-released niacin can be used after niacin tolerance is established, but this form of niacin can be harder on the liver. Just be careful and make sure your doctor is monitoring liver enzymes and CBC every month or so until tolerance is well established. Unfortunately Niacinamide, ("No Flush Niacin") does not appear to be as effective.

Adding herbs that increase nitric oxide synthase (NOS) activity can also be helpful and can lead to improved immune function and warmer extremities. Garlic, ginseng, & ashwagandha all increase the activity of NOS and may be synergistic in combination with niacin. Increasing nitric oxide usually decreases FM related muscle pain and anxiety. One of the following articles supports the use of niacin for chronic headache (Mayo Clinic article) and another links infection with Cpn to disruption of niacin metabolism and immune evasion.Make sure that you are taking a good multivitamin daily when doing battle with Cpn. Nutritional demands are increased significantly by increased exposure to the endotoxin that is released from dying organisms.  Biochemicals made by the the body to fight Cpn are  made at the expense of tryptophan, niacin, melatonin, and serotonin all of which also are needed to fight Cpn in other ways. Supplementation with niacin and melatonin should make life more difficult for Cpn.

Best wishes to all of those who striving to be a bad host to Cpn. The last two articles document the effects of nitric oxide and melatonin on Cpn.

Michael Powell D.O.

Studies referenced:

Mayo Clin Proc. 2003 Jun;78(6):770-1.

Sustained-release niacin for prevention of migraine headache.


Velling DA, Dodick DW, Muir JJ.

Division of Pain Management Mayo Clinic, Scottsdale, Ariz 85259, USA.

Considerable advances in the diagnosis and treatment of migraine headache have occurred during the past decade, but treatment options for acute migraine attacks have expanded at a faster rate than those for prophylaxis. We describe a patient whose migraine headaches responded dramatically to sustained-release niacin as preventive treatment. Niacin is not generally considered to be effective for migraine prevention. However, low plasma levels of serotonin have been implicated in migraine pathogenesis, and niacin may act as a negative feedback regulator on the kynurenine pathway to shunt tryptophan into the serotonin pathway, thus increasing plasma serotonin levels. Sustained-release niacin merits further study as a potentially useful preventive therapy for migraine headache.

PMID: 12934790 [PubMed - indexed for MEDLINE]

Can J Microbiol. 2005 Nov;51(11):941-947.
 
Effect of nitric oxide on the growth of Chlamydophila pneumoniae.


Carratelli CR, Rizzo A, Paolillo R, Catania MR, Catalanotti P, Rossano F.

Chlamydophila pneumoniae is an important human intracellular pathogen; however, the pathogenesis of C. pneumoniae infection is poorly understood and the immune control mechanism versus host cells is not completely known. The role of the nitric oxide (NO) synthase pathway in inhibiting the ability of C. pneumoniae to infect macrophage J774 cells and the ability of NO to damage isolated C. pneumoniae were investigated. Exposure of infected cultures to recombinant murine gamma interferon (MurIFN-γ) resulted in increased production of NO and reduced viability. Addition of 2-(N,N-diethylamino)-diazenolase-2-oxide before infection of J774 cells or during chlamydial cultivation released NO, both resulting in a reduction in the viability of C. pneumoniae in a dose-dependent way. These results indicate that immune control of chlamydial growth in murine macrophage cells may trigger a mechanism that includes NO release with effects on the multiplication of the microorganism, thus suggesting that NO may play a role in preventing the systemic spread of Chlamydia.

PMID: 16333333 [PubMed - as supplied by publisher]

J Antimicrob Chemother. 2005 Nov;56(5):861-8. Epub 2005 Sep 19.
 
Serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite chlamydia.


Rahman MA, Azuma Y, Fukunaga H, Murakami T, Sugi K, Fukushi H, Miura K, Suzuki H, Shirai M.

Department of Microbiology, Yamaguchi University School of Medicine, 1-1-1, Minamikogushi, Ube, Yamaguchi 755-8505, Japan.

OBJECTIVES: Chlamydiae are obligate intracellular bacteria, causing a variety of diseases, i.e. pneumonia, sexually transmitted disease, conjunctivitis and zoonosis. Tryptophan depletion by interferon-gamma (IFN-gamma) is the most important host defence system against chlamydial infection. Thus chlamydial tryptophan metabolism is thought to play key roles for IFN-gamma resistance, persistent infection and host/tissue tropisms. We tested tryptophan derivatives for activity against chlamydia-infected cells. METHODS: Rates of chlamydial infection and sizes of the inclusions were evaluated by in vitro infection using three Chlamydiaceae species, Chlamydia trachomatis, Chlamydophila pneumoniae and Chlamydophila felis, which show significant divergence of tryptophan synthesis genes and different susceptibilities to IFN-gamma. RESULTS: Melatonin and serotonin, which are recognized as neural hormones for maintenance of organism homeostasis, reduced chlamydial infection but not other bacterial growth tested here. Unlike IFN-gamma, melatonin limited infection of all three chlamydiae and the effects were not recovered by tryptophan supplementation. Melatonin treatment only of host cells could diminish infection and the infection reduction was neutralized by a pertussis toxin, an inhibitor of G proteins. Ligands of melatonin and serotonin receptors also hampered infection. CONCLUSIONS: Inhibition mechanisms of chlamydial infection by melatonin and serotonin appear to be different from those of IFN-gamma and involve specific G-protein-coupled receptors. Melatonin is deemed to inhibit early progression of the chlamydial development cycle, such as establishment of intracellular infection and/or conversion from elementary body to reticulate body. Utilization of melatonin, serotonin or their derivatives may be advantageous for harmless prevention of chlamydial infection.

PMID: 16172105 [PubMed - in process]

I've started on niacin and am ramping up, taking about three doses a day: 250mg each of Trader Joe's time release (5oomg tabs broken in half). It does induce some flushing/itching,but less so over time. I built up to this dose. Really helps the cold hands and feet and shivery feelings of endotoxin relelease. 

On Wheldon/Stratton protocol for Cpn in CFS/FMS since December 2004.

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

lee

Can somebody please explain this in laymans terms. Funny that when I took my dog to the vet for dry eye( same as me) He put him on 1500mg of tetracycline and niacinamide.

thanks

200mg doxy daily, 500 zithromax mwf,flagyl 1000 m-fri.rifampin 2x daily,chloestryramine 2x daily

Niacin & Cpn Simple:

  1. Cpn disturbs niacin metabolism. 
  2. This results in  impaired T-cell function, low melatonin, low serotonin, low tryptophan, low niacin, all of which are problems for us (depression, insomnia, immune problems, etc.)
  3. Niacin also counters endotoxin reactions (cold hands and feet, low body temperature, etc)
  4. You have to use regular niacin, which causes a flushing reaction (I get itchy too), and have to ramp up gradually, and you will tolerate higher dosage as you build.
  5. Gear towards 500-1000 mg per day spread over the day.
  6. As it can be liver toxic in these larger doses, make sure your liver and CBC blood panels are checked regularly if you are using this supplement in this way. 

On Wheldon/Stratton protocol for Cpn in CFS/FMS since December 2004.

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Doesn't sleep deprivation disrupt the the body's production of melatonin? Could this be why my infection ramped up when I had insomnia for so long from menopause? Low melatonin allowed more Cpn to grow and establish itself as the reticulate form. Interesting. I know I have had the infection for a long time, but it really began to wreak havoc on my body when I began going through menopause. "Melatonin is deemed to inhibit early progression of the chlamydial development cycle, such as establishment of intracellular infection and/or conversion from elementary body to reticulate body." Raven

Feeling 98% well-going for 100. Very low test for Cpn. CAP since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NAC,BHRT, MethyB12 FIR Sauna. 1-18-11 begin new treatment plan with naturopath

SHOULD I START ON NIACIN?  I'M ON MY SEVENTH DAY OF TINIDAZOLE (TINDAMAX) 500 2X DAY.  I STARTED MELATONIN LAST NIGHT SO I COULD SLEEP. I DID SLEEP (WHEW WHAT STRANGE DREAMS!) BUT WOKE UP IN MORE PAIN THAN I'VE HAD IN AGES.  MOSTLY EYE,FACE, SINUS, & MAJOR SPINE NECK HEADACHE SWELLING THING & CRYING.  COULDN'T MOVE TILL THE ASPIRINS KICKED IN. ( MY POOR DOG HE HAD TO PEE BUT I COULDN'T MOVE TO LET HIM OUT.)

SO MY QUESTION IS THIS WILL NIACIN HELP MY MUSCLE PAIN OR IS IT TOO EARLY TO START SINCE THIS IS ONLY MY FIRST PULSE.   ALSO WILL THIS REACTION STOP ONCE I STOP THE TINI, OR DOES IT TAKE A WHILE TO GET BACK TO NORMAL? 

THANKS ROG777 Cry

Rog777- Most people do pulses for 5-7 days, then rest. The impact of a pulse continues on for a nubmer of days after as cleared cells are mobilized.

There is no contraindication to using niacin with tini that I know of, start gradually as Dr. Powell. 

I found the best thing to counter toxicity from the Tini pulses has been a Vitamin C flush. It's referenced somewhere on the site, using buffered vitamin C powder. It's the thing that helps me the most, about day 3 of a Tini pulse.

On Wheldon/Stratton protocol for Cpn in CFS/FMS since December 2004.

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Maybe I missed something but I need to ask why you are doing such a long pulse.  I always feel much worse when I am on Flagy and am always happy to be done.  My body always needs the whole "off time" to recover.

Rica 

Ignorance is voluntary bad luck.  Lauritz S.   A true Viking

If you come to a fork in the road, take it. Yogi Berra

3/9 Symptoms returning. Began 5 abx protocol 5/9 Rifampin 600, Amox 1000, Doxy 200, MWF Azith 250, flagyl 1000 daily. Began Sept 04 PPMS EDSS 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

10 DAYS OF TINI IS WHAT MY DOCTOR PRESCRIBED.(FROM THE FIBRO CLINIC IN OHIO)  I ONLY TAKE 500 MG 2X DAY IN CONTRAST TO SOME WHO TAKE 1500 A DAY.  TtHIS HEADACHE DRIVING ME CRAZY & IS NOT RESPONDING TO MY USUAL ASPIRIN AND MIGRAINE MEDS. ALTHOUGH I DON'T HAVE THE FATIGUE THAT I USUALLY HAVE. I'D LOVE TO QUITE TODAY IF SOMEONE SAYS ITS OK.

ROG Cry

HOW MUCH C FOR A C FLUSH.  I TAKE 2,500 ESTER C CAPS ( 5 500MG) ABOUT 2-3X DAY JUST TO FIGHT THAT FEVERISH FLU FEELING THAT I HAVE MOST OF THE TIME. I'VE TAKEN LESS OFTEN PER DAY SINCE I'VE BEEN OF DOXY AND ZYTHRO.

ROG 

 Try this link for info on Vitamin C flush: http://www.askrph3.com/healthcare/article_cflush.shtml

Note: it uses buffered vitamin C powder, not tablets. Best brands I've found: by Nutricology (available at Vitamin Shoppe) and American Biologics Ultra AB-C which has added quercetin.

On Wheldon/Stratton protocol for Cpn in CFS/FMS since December 2004.

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Jim, how is it going with the niacin treatment? I spoke with Dr. Powell by phone and he recommended that I take it. (as well as B5 and B6 and the Horny goat Weed--LOL) I bought some at Trader Joe's but have ony taken a quarter dose as I used to get some extreme itching/flushes from niacin. He thought a prescription brand might be better for me to take. I'm being a big chicken about this so any info would be encouraging. Raven

Feeling 98% well-going for 100. Very low test for Cpn. CAP since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NAC,BHRT, MethyB12 FIR Sauna. 1-18-11 begin new treatment plan with naturopath

Hi Raven- I did the same thing with the Trader Joes time release version: split it in half and gradually worked up to 1.5 tablets (1/2 at breakfast, lunch and dinner). I have the Rx kind from him, but haven't started it yet. Taking HGW, but not the added B5 and B6 yet.

I've found it helpful to counter the endotoxin cold (hands, feet, body). It also makes life harder for the Cpn according to his research, so that's good too. The itching response gets easier, so you can increase dose to tolerance. I think I'm at max now, since when I start to increase blood flow (exercise) I get a flush of itchy scalp and face! Just go slow. Try the 1/2 with food, and you'll get short flushes shortly after (I don't think the time release is that good on the Traders version), but it subsides rapidly. Build up as you are comfortable. Listen to your doctor! He's a good one.

On Wheldon/Stratton protocol for Cpn in CFS/FMS since December 2004.

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Im bumping this as I'm interested in adding in Niacin at some point. However I read that Niacin can induce porphyria. I think it was the genetic porphyria, but would assume holds true for CPn secondary porphyria.

Has anyone had any experience with this? I know people have had bad reactions to niacin which are chalked up to "die off", so wondered if it was the same thing.

Chronic sinusitis, more recently noticed neurological and cognitive problems. Gotten more severe.
CPn, mold exposure.

"In addition, high doses of niacin can cause an acute attack in someone with porphyria, simply because niacin stimulates the production of heme."

http://the-medical-dictionary.com/porphyria_article_4.htm

I believe porphyria is the issue ive been dealing with mostly. The precipitating factors which have led to my periods of feeling most horrible, confused, and cognitively impaired, have been:

Fasting, taking NAC moving to higher altitude (low O2 makes it worse), catching planes, a panic attack leading to overbreathing (low O2 again).

I will look forward to adding in niacin later, and in much smaller doses initially. I think it's necessary to help heal the damage from CPn. But for now I must wait I guess. Going too quickly has screwed me up in the past, and will most likely continue to do so.

Chronic sinusitis, more recently noticed neurological and cognitive problems. Gotten more severe.
CPn, mold exposure.

We got some high dose niacin to try, when I was a year into intermittent protocol. It made me very red faced and a bit itchy so I stopped it after a few days. Not die off by then I think.

I made David stop it as well because it was giving him a lot of little thread veins on his nose and cheeks.

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.