Problems taking doxy/mino

Hi guys, I just posted an intro story on my blog here:

http://cpnhelp.org/node/14017

But basically, got CPn, Lyme, mold exposure, and Im struggling to take doxy/mino. See blog for more info.

My liver was tested before any Abx, and enzymes were fine. I started on doxy, was feeling ok, but a few weeks in, after adding the roxy, I had liver enzymes slightly elevated on a test. I knew I had to add tinidizaole later, so my CPn doc thought I should switch to mino. I tested the roxy +mino combo on a test, and the liver enzymes were fine, back to normal range.

But... within the first a day, I developed terrible gut issues. Swallowing food, it felt like it scraped down my esophagus with no lubrication. I had panging abdominal pains, radiating to the back. I thought maybe these would be transitory, but after four weeks they were still there. Also, i felt more dizzy and wobbly on it, and had a strange mental state, though that could be herxes or other things.

Right now, im just on roxy, and have done two days of tinidazole. My CPn Dr said just being on roxy for a while + tini would be ok. I also need to do some more mould treatment / toxin binding before I amp up my CPn / Lyme killing (see blog).

However... after the roxy + tinidazole pulse... I got a strep throat infection! And hence needed to take penicillin for ten days on empty stomach away from food, along with keeping on taking the roxy. So had to stop on taking the binders, temporarily, since they'd absorb the penicillin. I tested my liver enzymes after tinidazole + roxy and they were elevated, this time even more than before. The Dr thought it could be just the strep throat infection, but I suspect the tini pulse contributed.

Anyway, Im back on roxy + just restarted the binders. It seems to me that if I am going to do the full CAP, then its going to be a choice of mino, which makes me feel bad and gives terrible gut symptoms, and doxy, which seems to be hard on my liver, so... really don't think I can be on it long term.

Ive got a whole bunch of liver tests requests from my GP, so im going to test again. If its all normal, i MAY try add in doxy or Mino... but am afraid of getting bad side effects again and having to stop. And I know stopping + starting isn't good - I think that may have contributed to me getting strep throat! However I really did try to persevere with the mino, but the sides were terrible

Any advice?

Well, I'm not telling you what to do, but just saying that I have never had a liver enzyme test. I did ask David if he thought I ought to have one, but basically he said to concentrate on getting better and don't worry about liver enzyme tests unless I turned yellow. Well, I never turned yellow, but I did get better.
Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Rica! As I recall, you had some elevated liver tests? Could you chime in, please?

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Haha Sarah i like the cut and dry nature of David's advice, and am very happy you never turned yellow and got well :)

In my case, since I dont have MS, my problem is that I don't know how much of a role CPn is playing in my illness. I mention this in my first blog post. CPn is certainly not the only thing. My symptoms are much closer to mould illness, which I have, and maybe Lyme disease. For mould illness in particular, the liver is very important in terms of detoxing, so I'm hesitant to do anything to make it worse!

Anyway, ill make some decisions and keep people updated. Thanks for the replies Sarah and MacKintosh

Chronic sinusitis, neurological and cognitive problems. Gotten more severe recently.
CPn, mould exposure, likely Lyme
Roxy, supplements, red/infrared light, cholestyramine. Will start pulsing tini again at some point.

I guess, my main question actually boils down to this - would Roxythromycin + Tinidazole (+ NAC, etc) do much to kill CPn / reduce the bacterial load?

Or should I hold off on the tinidazole? Until I find either a way to tolerate doxy/mino, or find another antibiotic I can tolerate

Chronic sinusitis, neurological and cognitive problems. Gotten more severe recently.
CPn, mould exposure, likely Lyme
Roxy, supplements, red/infrared light, cholestyramine. Will start pulsing tini again at some point.

It has been a long, long time for me, so I can't answer that as clearly as I could have before, but I was knocked FLAT for a while. I don't know how to avoid the effects of our protocol and so "just did it" Absolutely no regrets. I am now 78 years old and do LOTS of work every day. Rica

3/9 Symptoms returning. Began 5 abx protocol 5/9 Rifampin 600, Amox 1000, Doxy 200, MWF Azith 250, flagyl 1000 daily. Began Sept 04 PPMS EDSS 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

Thanks for the reply - yours is an inspiring story! :)

Once again it boils down to me not knowing how much of my issues stem from CPn, and how much from mould and other things. If it was my only issue I would 100% "just do it". But since im treating a few things at once I need to be a bit more careful. That being said, I fully intend to give these awful bugs the full treatment at some stage. Im just currently dialling up the rest of my treatments (gotten away from mould, starting to take cholestyramine, etc)

Chronic sinusitis, neurological and cognitive problems. Gotten more severe recently.
CPn, mould exposure, likely Lyme
Roxy, supplements, red/infrared light, cholestyramine. Will start pulsing tini again at some point.

Ok well it seems like if not CPn, Lyme and tick borne diseases, are certainly playing a major role for me.

Will post an update on whats transpired to make me think this, on my blog

I need to get back on doxy/mino and work out a way to tolerate them ASAP. Im confident ill find a way

Lyme is treated in quite similar ways (but not exactly) to CPn anyway, which is it's closest cousin apparently.

Chronic sinusitis, neurological and cognitive problems. Gotten more severe recently.
CPn, mould exposure, likely Lyme
Roxy, supplements, red/infrared light, cholestyramine. Will start pulsing tini again at some point.