27 Apr 2018

Another Good Article - The vitamin D-antimicrobial peptide pathway and its role in protection against infection


Hi Garcia,

Here is the other side of the argument which as you mentioned comes direct from the Marshall site. I still agree with you and like many papers that get published these days, this most likely shows an association, not a correlation...


Vitamin D in rheumatoid arthritis
Maurizio Cutoloa, Kati Otsab, Maria Uprusb, Sabrina Paolinoa and Bruno Serioloa
aResearch Laboratory and Academic Clinical Unit of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6 - 16132 Genova, Italy
bDepartment of Rheumatology, Tallinn Central Hospital, Tallinn, Estonia
Received 2 July 2007; accepted 24 July 2007. Available online 14 August 2007.

The discovery of the vitamin D receptor (VDR) in the cells of the immune system and the fact that activated dendritic cells produce the vitamin D hormone suggested that vitamin D could have immunoregulatory properties. VDR, a member of the nuclear hormone receptor superfamily, was identified in mononuclear cells, dendritic cells, antigen-presenting cells, and activated T-B lymphocytes. In synthesis, the most evident effects of the D-hormone on the immune system seem to be in the downregulation of the Th1-driven autoimmunity. Low serum levels of vitamin D3 might be partially related, among other factors, to prolonged daily darkness (reduced activation of the pre vitamin D by the ultra violet B sunlight), different genetic background (i.e. vitamin D receptor polymorphism) and nutritional factors, and explain to the latitute-related prevalence of autoimmune diseases such as rheumatoid arthritis (RA), by considering the potential immunosuppressive roles of vitamin D. 25(OH)D3 plasma levels have been found inversely correlated at least with the RA disease activity showing a circannual rhythm (more severe in winter). Recently, greater intake of vitamin D was associated with a lower risk of RA, as well as a significant clinical improvement was strongly correlated with the immunomodulating potential in vitamin D-treated RA patients.

- Paul