Cpnhelp.org

Yilmaz, I may be wrong about this but increasing titers could well be expected as one treats CPn in the initial months, even years.  the more there is of it killed off the more your immune system sees and can become reactive to as a result of more of it (even dead) in the blood stream.   I just wonder if you are putting to much emphasis on the reaction to Vit D supplementation in looking at your seemingly progression of symptoms.   I am not suggesting you do more Vit D your level 64ng/mL is certainly not low now.   I wonder if you have had your eyes examined yet and am glad that your vision is now better. 

Could the atrophy be another muscle wasting disease?  We have had another user here from your country with a muscle focused illness.  Pmessage me and I will give you his bloglinks.  I have wondered what has transpired with him. 

I will be waiting for news of your posts regarding your Lyme tests and your neurological tests.   I am hoping that to continue on CAP is appropriate for you as a result of what you discover.  I hope this for you because from my perspective, most of these chronic situations have little other effective therapies that I am aware of.

Blessings to you Yilmaz, you bring a lot of help to this sit for many here.

Louise  

 Lousie, I went to see an ophtalmologist. After examining me he said that it was blepharitis and gave me 2 drops; one containing antibiotic and other containing cortisone. I used them and I feel better but visual symptoms started again, just today(I increased the dose of roxy and added rifampin 2x300mg). I believe that they are die-off or prophiric symptoms related to photosensitivity, looking to pc screen all the day;at work and at home; may be one reason for this photosensitivity. My major concern is related to muscular atrophy which can not be die-off.

 YILMAZ.

"As for the vitamin D receptor / Benicar stuff, where exactly does that come from? If it's Marshall's molecular modeling, I'm afraid I don't trust that one bit."

Yeah well, this is all what he has to back it up at the moment when it comes to research. He did go through all the different angiotensin blockers, and concluded that Olmesartan worked best. I'm not going to argue about this further, since there are no hard facts to back it up.

But one thing that sure needs to be done is to distinguish these infections from each other. It seems that mycoplasma or tuberculosis-like bacteria are another species that are nearly as good as Cpn to take over the body. And these bacteria seem to disable the immune system in a way that differs from Cpn. Of course those who have sarcoidosis or other granulomatous diseases also have Cpn, but they don't have just Cpn. And these co-infections can be so problematic that you need to treat them specially before you even get your hands at Cpn.

I have done some atomistic simulations in physics, but I don't know about how you can apply it to biological systems.

"pgm, when I look at your supplementsi I can not see VitD3 between them, so I wonder whether youever took VITD in the past and what's your blood level of 25(OH)VitD3. As you know,there are many of reports saying that VITD is helpfull on depression and cognitive issues."

I haven't taken any VitD3, but I don't try to avoid it from food or sunlight exposure. This is ridiculous anyways, and they should know it better on the MP site, that sunlight sensitivity is likely caused by porphyria. They even get it from Benicar alone, not just abx cause it. But of course I could try VitD3, but I don't believe in miracles. It might just generate more die-off, and this is not what I want.

I don't believe that lack of vid-D3 can cause depression, the bacteria are in the brains (and CNS), where they cause imbalances in more important neurotransmitter substances that are directly related to brain function. Feels a bit like you sometimes have sand in the head, when you try to kill these buggers. I'm also supervising a treatment for a person who have had panic attacks and depression and CNS involvement is quite clear. Sometimes bacterial die-off can generate a feeling of internal tremors, which I assume is caused by porphyria in CNS, someone on this site said it at least.

Sarah, I believe that my 10,000 had only contributed to my improved mood too.   Louise

  Maria, first of all I wonder what the your neurologic diagnosis is.

  Yilmaz, why do you not think that your muscular atrophy can be die-off?

  It may be die-off infact but I don't want such kind o die-off.  ıf die-off reactions may cause muscular atrophy how can I go on swallowing antibiotics bravely. I will go on taking antibiotics and my muscles will continue to wasting. It's possible that I will lose my capability of working, capability of using my arms, capability of walking, capability of any motion, capability of respration(if the respiratuar muscless were involved) etc.

  What's the mechanism for muscular atrophy; there may be many alternatives, muscle cells may be dying off directly(if they are infected), or neurons controlling muscular activity(anterior horn motor neurons forexample) may be dying off(if they are infected) which means ALS. You don't know which kind and how many cells are infected. So we can not know when these die-off will stop.

  yılmaz.

 Don't mention it. Maria, do you have a neurological diagnosis?

My best.

Sarah, I would be jealous if I were a drug dealer :)

 I agree with Sarah, when I take vitD I feel happy also. May be this s due to it's taste, I take it as drops on my bread, I like it's taste.

YILMAZ.

Vitamin D for depression isn't just anecdotal; here's a study finding it effective against "seasonal affective disorder" (aka the wintertime doldrums). But as far as anecdotes go, add mine to the list; I also got more mental energy after starting high-dose vitamin D.

As regards:

I have done some atomistic simulations in physics, but I don't know about how you can apply it to biological systems.

With great difficulty! The basic equation to be solved is the Schroedinger equation; and the Schroedinger equation for N electrons is a 3N-dimensional partial differential equation. It's most difficult even to solve it for a single atom; even with just two electrons, you're dealing with a six-dimensional equation. If each of those dimensions is discretized using a hundred points, it yields a trillion-variable problem -- just within the reach of today's computers, and that's just the helium atom. Go up to lithium, and you've added another three dimensions to the problem, and another factor of a million in the number of variables. Carbon? Forget it.

What they do in practice, to get a problem small enough for computers to handle, is to pile approximation on top of approximation on top of approximation, until it becomes very uncertain as to what relationship to reality the results have. Still, I wasn't surprised to see Professor Ceder's name on the list of authors of a recent breakthrough in lithium battery charge/discharge speed; he seemed like the more practical of the two teachers of that MIT course.

"Vitamin D cause depression? Quite the opposite, I would have thought."
Well I didn't say that, just that I don't believe that lack of VitD causes depression.

"With great difficulty! The basic equation to be solved is the Schroedinger equation; and the Schroedinger equation for N electrons is a 3N-dimensional partial differential equation."

To be more accurate it was molecular dynamics (MD) simulations, where clusters were bombarded on a surface. The simulations TM used are of the same type (MD). You can forget about more accurate simulations anyways, if you want more than hundreds of atoms. With MD you can probably come up to millions of atoms at a time. Simulation times are limited though, and accuracy too (only applicable to some situations). What TM studied was docking of a molecule into a receptor or something like that. You can do many things with MD anyways.

To do molecular dynamics, you need some formula for the forces on the molecules (or, to be exact, on the atomic nuclei, whose dynamics can reasonably be modeled using classical physics). Those forces really should come from the Schroedinger equation; but since that is impractical, various approximations are used.

As for not believing that lack of vitamin D can cause depression, all I can say is: give it a try.

I think the vitamin D issue needs to be discussed a bit further. After having read TM's paper about vit D metabolism in humans, it becomes clear that the mainstream is not even aware of how the metabolism works in detail (e.g. what feedbacks exist):

http://www.ncbi.nlm.nih.gov/pubmed/18200565

Namely, while the 25D metabolite is often said to be the inactive form, that just floats around bound in the plasma with little other effects, it does affect e.g. the PXR nuclear receptor, which further transcribe some CYPs that further transcribe the VDR. In TM's paper, he clearly states that 25D does not bind to VDR nuclear receptor, so this is not the issue, but the 25D can and does bind to PXR.

But the 1,25D is still the active hormone that does all the important job, e.g. antimicrobial peptides etc, so why do we want to have high 25D, when this is not the active form of the vitD hormone. The 1,25D has a magnitude of three orders smaller than 25D, you'll always have enough of it, regardless what your 25D status is, and the 25D and 1,25D are not directly coupled even.

  pgm, I read the abstract and didn't see anything related to PXR nucleer receptors. If you have the complete article please post it here.

  ''The 1,25D has a magnitude of three orders smaller than 25D, you'll always have enough of it, regardless what your 25D status is, and the 25D and 1,25D are not directly coupled even.''

  I'm not sure whether this statement is true or false. Because, as far as I know, the measured 1,25D is the 1,25 D which is synthesized by kidney and regulates Ca homeostasis. But the 1,25D which act on nucleer VDR are recieved from circulation into the cell of anykind and then converted to 1,25D within the cell, and the blood levels are important for internalization of 25D  by cells. If the blood level of 25D is low, then it would be difficult for many cell to find a 25D and take it inside.

  pgm, you know, the incidence of MS and some other autoimmune diseases are lower in equatorial places, how does TM explain this issue?

  yılmaz.

The 1,25-D blood level is the thing that is three orders of magnitude lower than the 25-D blood level. Levels of 1,25-D outside the blood can be much greater than blood levels -- indeed, they have to be, for leakage into the blood to be an issue. Those outside-the-bloodstream applications of vitamin D don't draw 1,25-D from the blood; they draw 25-D from the blood, and convert it into 1,25-D. That's why a high 25-D level can be useful. In the conversion from 25-D to 1,25-D, a higher 25-D concentration means a proportionately higher 1,25-D concentration. To quote from the recent review by Cannell and Hollis:

... the liver enzymes that initially hydroxylate vitamin D to form 25(OH)D and the enzyme in tissue that generates 1,25(OH)2D operate below their Michaelis-Menten constants throughout the full range of modern human substrate concentrations; i.e. the reactions follow first order mass action kinetics. The more vitamin D that is ingested, the more is converted into 25(OH)D, and the more is converted into 1,25(OH)2D in the tissues.

They go on to note that the kinetics ceases to be first-order, for the conversion of vitamin D into 25-OH-D, when the vitamin D concentration gets sufficiently high, and suggest that the resulting 25-OH-D levels are probably the optimal ones for best health.

The reason this doesn't apply to 1,25-D blood levels is that those levels are part of a feedback control loop. The kidneys dump however much 1,25-D into the blood is needed to regulate calcium; they stop dumping in 1,25-D when calcium is high enough. A lower 25-D concentration just means that the dumping happens slower, not that the final result is much different.

By the way, there are undoubtedly plenty of feedbacks in the immune system usage of vitamin D, too. But some of those feedbacks are doubtless of the form: vitamin D is activated => cathelicidins or other germ-killing things are produced => germs die => immune system senses that there are no more germs to kill and stops activating vitamin D.

 Norman, how do you think VitD kill CPN, by apoptosis of infected cells and/or some other mechanisms?

 yılmaz

"pgm, I read the abstract and didn't see anything related to PXR nucleer receptors. If you have the complete article please post it here."

Just google for the paper name, TM keeps preprints of all of his papers on his website. I suppose you dont want links here to TM's site.

"pgm, you know, the incidence of MSi and some other autoimmune diseasesi are lower in equatorial places, how does TM explain this issue?"

He doesn't explain it, but it can be explained in some other ways too. Since MS can also have a viral component in it, sunlight (and therefore UV light) kills viruses or makes them inactive, and makes their spreading more difficult when there is more sunlight.

" The 1,25-D blood level is the thing that is three orders of magnitude lower than the 25-D blood level. Levels of 1,25-D outside the blood can be much greater than blood levels -- indeed, they have to be, for leakage into the blood to be an issue."

Good point - you'll have to dig into the issue more to find this explained. The wikipedia entry on vit D is just crap.. hahhaa. And I don't have the energy to dig through tons of papers on vit D. Thanks for this clarification.

   Since MS can also have a viral component in it, sunlight (and therefore UV light) kills viruses or makes them inactive, and makes their spreading more difficult when there is more sunlight.

   pgm, it is not a good explanation; if you try to explain lower incidence of autoimmune diseases in equatorial places with the any effect of sunlight, how can you believe a man who advice to people, with outoimmune diseases, to run away from the sun? It doesn't matter how sunlight helps, whether by killing viruses or in some other ways.

   If TM claims that 25D is harmfull in autoimmüne diseases he should find a reliable explanation for this issue, orelse he must stop talking.

  yılmaz.

"pgm, it is not a good explanation; if you try to explain lower incidence ofautoimmune diseasesin equatorial places with the any effect of sunlight, how can you believe a man who advice to people, with outoimmune diseases, to run away from the sun?"
I didn't say I believe him, but there seems to always be some alternative explanation for something, so it's a bit hard to say anything definitive at this point. At this point I assume that Vit D3 can be useful to some people. And I'm still puzzled that some people get symptom palliation from large doses of D3, while others get just more die-off. Those who get die-off appear to be in a better shape to be begin with.

" Those who get die-off appear to be in a better shape to be begin with." (quoting pgm)

Where is the evidence for this?

  pgm, I know there may be some different explanations, forexample I read one saying that the lower incedence of MS in equatorial region is due to differences in magnetic forces not due to VİTD (it was in Turkish so I didn't post it).

  I couldn't get the whole article you posted. When I read abot MP I see only what TM says; 25D is an immünesuppressive secosteroid, I can not see any scientific evidence and good explanations about the mechanisms for these claims (there may be but I didn't see anyone). TM also seems to be changing his mind about VİTD, he was advicing people to run away from sun previously, but nowadays I see him saying that  supplementation of 25D acts differently than VİTD synthesized by skin with the help of sun, this supplemented form of vitD is harmfull. So he seems to be twisting.(If I misunderstood please let me know).

  In my thought, there seem to be a confusion about MS-CPN infection-VİTD relationship. I will try to summarize how it looks from my point of view; these are what the people here believe or know.

 1)MS is an intracellüler infection caused by CPN

 2)Vit D is very helpfull against MS

 3)Main way of body for elimination of intracellüler pathogens and CPN is Th1 immüne response.( cellüler immünity)

 4)overactive Th1 is responsible for the collateral neurological damage which is the major form of damage seen in MS.

 5)VİTD helps by balancing immüne system towards Th2, so it decreases collateral damage.

   And this is the questionmark on my mind;

 If MS is an intracellüler infection caused by CPN, how decreased Th1 may be helpfull, especially in big majority of patients who doesn't take antibiotics, ıt may help; at the beginning; by preventing immüne damage but since decreased Th1 would result in an increased infection I would expect it to give harm in long term.

   There may be many different answers, some of which are below.

 1)MS is not an infection, it's an autoimmüne disease caused by Th1 and VİTD is helpfull.

 2)MS is an CPN infection and VİTD gives harm in long term infact.

 3)MS is an CPN infection and VİTD helps by decraising Th1, it also doesn't cause infection to get stronger, VitD may have some powerfull antiinfective properties against CPN which we don't know yet, so while decreasing immüne damage it also fights with CPN  and beat it. (Since there's no evidence that cathelicidins is effective against CPN, I don't think that cathelicidines help, I also don't believe that apoptosis would help, because it may result in phagocytosis of apoptotic cell by macrophages which in turn would make CPN very happy, since macrophages will work as a CPN factory and CPN will feel itself at home)

 4)MS is an infection but not an CPN infection, it's caused by another pathogen against which VİTD, defensins, cathelicidines and apoptosis would be effective.

  We can lengthen the list; what I want to believe is number 3, since we have some pistol against CPN and VİTD would be a powerfull one.

  yılmaz.

"" Those who get die-off appear to be in a better shape to be begin with." (quoting pgm) Where is the evidence for this?"

That's just my anecdotal findings. I have some, but ignore this for the moment.

I think we can finally reach an agreement here on this topic if we abandon just a part of Marshall's theories (namely that 25D is immunosuppressive, which appears to be incorrect) and add the other part from the mainstream research.

The part that appears to be right in the MP is that Benicar is useful for some people. Because many people on the MP start to get sunlight sensitive after starting Benicar; that means they start getting die-off again from vitamin D. If you don't take Benicar, vitD will have no or little effect.

So what you need actually is Benicar + VitD3, and not necessarily any antibiotics to start with. Just take the Benicar, get out in the sun and as much as you can tolerate it and there you go.. use appropriate moppers for porphyrins, like DMSA, and there you have e.g. the Benicar - Sun - DMSA protocol :). Definitely worth a try if you dont get a proper response on abx alone. The die-off can be rather strong from Benicar alone some say.

But as you know, not all infections are like this.. I don't yet know what kind of species you need to have to get VDR blocked, or whatever makes the Benicar useful. I just go by die-off reactions, they are the most reliable indicators that something useful is happening.

"I couldn't get the whole article you posted. When I read abot MP I see only what TM says; 25D is an immünesuppressive secosteroid, I can not see any scientific evidence and good explanations about the mechanisms for these claims (there may be but I didn't see anyone). TM also seems to be changing his mind about VITD, he was advicing people to run away from sun previously, but nowadays I see him saying that supplementation of 25Dacts differently than VITD synthesized byskin with the help of sun, this supplemented form of vitD is harmfull. So he seems to be twisting.(If I misunderstood please let me know)."

I dont know about this that he had changed his mind, but there we at least caught him; he is inconsistent in saying that people should avoid sunlight when it causes die-off, that's just what he wants people to have anyway, as it is a sign that the body is actively killing pathogens. It's cheaper to kill them with VitD3 anyways, as long as it works this way.

Well, while we covered the 25D previously, there appears to be some negative effects with high 1,25D. Here's a link to an interesting discussion about the MP: http://www.sciencebasedmedicine.org/?p=563#comment-28549. It seems that if 1,25D is high it suppresses interferon-gamma.

http://bloodjournal.hematologylibrary.org/cgi/content/full/106/13/4351

http://www.fasebj.org/cgi/content/full/21/12/3208

This all means that high 1,25D has some immunosuppressive properties. And if 25D is high, you'll get a high 1,25D in the immune system response as well (not necessarily visible in circulating blood levels). But as you can see in the above discussion about the MP, no one except for Marshall has his patients to measure also 1,25D in addition to 25D in blood levels. Although this idea was rejected earlier here, people with chronic disease appears to have high 1,25D and low 25D. What this really means remains to be inspected in more detail.

What this really leads to appears to vary according to what infection you have. An excessive supplementation of VitD3 is at least harmful in sarcoidosis, because it can lead to granuloma formation. In other diseases like MS, it can lead to immunosuppression, because of the interferon-gamma suppression that is important against viral infections. For the rest, more die-off of D3 supplementation can result. So what I said above about the Sun causing more die-off may not hold in all cases. And while i said previously that 25D doesnt seem to be immunosuppressive, this time we are discussing the effects of 1,25D, and this can unfortunately change the whole issue again. As long as we don't exactly know what 1,25D does, we can't say whether supplementing with 25D is useful or not.

  pgm, VİTD3 really seems to be ,immünsuppressive in some aspects, but it still can be beneficial for certain doses (we don't know what the true dose is yet)                                                                                                                          If MS is an intracellüler infection, we expect to see an overactivated Th1 response which will result in a heavy tissue damage inturn. So by supplementing VİTD3 we can balance the overactivated TH1, in certain doses ofcourse, and we can prevent the collateral tissue damage. It would be best for an MS patient to be on an appropriate antibiotic portocol also.

  What would happen to people who are not on an antimicrobial protocol. Normally I would expect them to have an increased risk of exacerbation of their MS in long term. But epidemiologic studies say just the opposite. People  get benefit from VİTD3 supplementation. So how can we explain this situtation?

  1-these studies are unreliable?

  2-MS is not a CPN infection, it's autoimmüne infact?

  3-VitD3 has some unknown antiCPN or antiinfective effects which neutrolizes or overcome it's immünesuppressive effects?

   yılmaz.

  Those are Dr. Stratton's thoughts about VİTD;

 ''I think that if you are treating Cpn with antimicrobial agents, the vitamin D supplementation is a non-issue. In fact, if it were “helping” them, as steroids may do (see attached), it would actually make the Cpn more susceptible to the antimicrobial agents. Take care. ''

 ''I suspect that most people are not getting enough Vitamin D simply because we all avoid the sun. I think everyone should be taking extra Vitamin D.''

Could you tell us what the question was, please? Out of context, I'm afraid I don't understand the answer without the specific question.

MacKintosh, Stratton seems to suggest that if vitamin D helps the Cpn, it works like a steroid. This is what Marshall calls vit D, an immunosuppressive steroid. If I did understand it correctly, e.g. excess cortisol (a steroid) transforms the Cpn from cryptic forms to replicating forms, and in that form they are more easily killed by abx. In this case vit D would have a similar action.

  pgm, thanks for good interpretation. I'm at hospital now and when turn back to home I'll try to post detailed discussion.

  yılmaz.

 That is the discussion with Dr. Stratton about DVİT3.(Q:QUESTİON, A:ANSWER)

 Q-Dr. Stratton; does Cpn has any effect on CD57 count?
 A-NK cells are important in the development of immunity against Cpn. Therefore, if there were a deficiency of NM function, immunity to Cpn would not develop. The Japanese believe that Chronic Fatigue Syndrome is a genetically related functional deficit of NK cells. What I don’t know is whether Cpn directly infects NK cells and thus may lead to poor functioning of these cells. I suspect this is the case, but I haven’t seen anything in the medical literature about Cpn infection NK cells.
Q-Dr. Stratton, so you say that NK cells are very important for body to fight against cpn by the activation of type 1 cellüler immünity which seems to me just the opposite of immünomodülatuar effect of VİTD3. So do you think that VİTD3 intake might be harmfull for cpn infected people and also for MS (at least after a certain dose)? What's the optimal levels of VİTD3 in cpn infected or MS people? Do you think more the vit D3, better the the effect on otoimmüne disease (unless intocsication)?
 A-I don’t think anyone knows the correct amount of Vit D3. Remember, an afternoon in the sun is 20,000 International Units. So, 1000 IU twice a day is not very much.

Q-Do you think much of VİTD3 may give harm by supressing Th1 cells? I take 5000 ıu myself and give myson 2000 ıu daily

A-I don’t think so. These doses (5,000 and 2,000) are quite small compared to being out in the sun. Take care.
Q- Dr. Stratton; which kind of immüne response, Th1 or Th2 type, would you prefer in a chronic CPN infection and which kind would you prefer in MS?
A-I would want a Th1 for an intracellular infection. See attached.

Q-So would you want a powerfull Th1 response in MS also?,
 As far as I know VitD3 strengthens Th2 response decreasing inflammation at the cost of decreased power against intracellüler infections.

A-Yes I would if it were caused by Cpn (see attached) and the patient was on antichlamydial antibiotics. Take care.
Q-Do you think VİT D3 may be harmfull after a certain dose(while still in nontoxic levels), by supressing Th1 too much. Do you believe VİTD3 is helpfull in MS infact?
A-I think that vitamin D3 is useful in MS and isn’t toxic. I don’t think suppressing the TH1 is a problem as antibodies are not important in MS.

Q-   Even if we talked about vit D, even if you send me some articles and even if I read may be hundreds of articles suggesting benefits of Vit D in MS, since these articles assume MS as an autoimmüne disease( rather than an intracellüler infection) and the effect of Vit d3 is different on intracellüler infections I want to be sure and confident while giving my children Vit D. I know VitD3 supreses Th1 response but do you think that may also be true?
 
''In people infected with cell-wall-deficient bacteria, the production of 1,25-D can spiral out of control and rapidly reach damaging levels.  This happens because, as an evolved survival mechanism, cell-wall-deficient bacteria are capable of catalyzing the process by which Vitamin D is converted to 1,25-D.  Instead of a slow, controlled conversion which occurs only in the kidneys, 1,25-D production becomes uncontrolled, occurring throughout the body inside cells infected with cell-wall-deficient bacteria. Specifically, immune system cells harboring cell-wall-deficient bacteria can turn into tiny, unrestrained factories producing excessive amounts of 1,25-D. Bacteria catalyze the 1,25-D conversion process intentionally to cause immune system suppression and create a more favorable living environment in the body. The result of catalyzed 1,25-D production is a subclinical yet devastating immunosuppression syndrome that allows Lyme Disease (and other types of cell-wall-deficient) bacteria to persist chronically in the body.  When present in appropriately controlled quantities, 1,25-D is a critical nutrient and is important to health, as we have said.  However, when present in excessive quantities, 1,25-D is immunosuppressive and inhibits the immune system from fighting infections. This process is one of the core survival mechanisms of Borrelia Burgdorferi.  The excessive levels of 1,25-D often present in people harboring chronic infections leads to a greatly inhibited host defense system. By accelerating conversion of Vitamin D to 1,25-D, these tiny bacteria are basically able to neutralize the human immune system.''   
  They also make a hint that Dr. James Shaller thinks similar and put some sentences from Dr.Bryan Bosner's book suggesting same thoughts.

A-Don’t worry about asking questions. I’ve been out of town and haven’t been getting my E-mails. I’ll get to your questions this weekend, but remember, I don’t have all the answers. I will go back and answer each question tomorrow. Take care.

Q-Dr. Stratton, you forgot me:((
A-I haven’t forgotten you. It’s just that June is the end of our academic year. I have been doing exit interviews and just haven’t had the time for thoughtful answers. I will do this as soon as I’m less busy. Take care.
Q-Dr. Stratton, there is some evidence showing that chlamydia sp. may misdirect immüne system towards Th2 for their own benefits. So there seems to be a potential, on high dose Vit D supplementation, for helping these organism. As you said before the true dose important.
A-I think that if you are treating Cpn with antimicrobial agents, the vitamin D supplementation is a non-issue. In fact, if it were “helping” them, as steroids may do (see attached), it would actually make the Cpn more susceptible to the antimicrobial agents. Take care.

Q-Dr. Stratton; this was your answer about vitD.
''I think that if you are treating Cpn with antimicrobial agents, the vitamin D supplementation is a non-issue. In fact, if it were “helping” them, as steroids may do (see attached), it would actually make the Cpn more susceptible to the antimicrobial agents. Take care. ''
  Would you advice an MS patient to get VİTD supplementation if he/she is not taking antibioyics?
A-I suspect that most people are not getting enough Vitamin D simply because we all avoid the sun. I think everyone should be taking extra Vitamin D.

A-

Thanks indeed for this posting, Yilmaz. I've made up my mind now what follows from this. I seem to have been fooled by the idea that immunosuppressive stuff never causes die-off. This isn't true of course, depends a bit on how your immune system is working. For those whose immune system works, I assume that luring out the Cpn from cryptic form to replicating form is enough to cause die-off, as this reveals the Cpn to the immune system.

The reason why I say that it's a bad thing to not get die-off from immunosuppressive stuff or abx is that the immune system doesn't seem to recognize the problem, and you are still left with the bugs. In this case, I would say that driving the immune system even more away from Th1 with vit-D would be a bad idea at least in the long term. Marshall's idea of avoiding vit D and taking Benicar for this problem seems to work well for this *subset* of people. It's just that this is not necessary for most(?) people. I'm of course open to other ideas of getting the immune system up and running for this subset of people. Perhaps supplement with interferon-gamma? :). And what are the causes of this problem? I'm betting for some other co-infection involved.

  pgm, I really don't know that, whether olmesartan (benicar) has any effect on VİTD recerptors, I didin't read any scientific report about that. We use olmesartan for antihypertansive purposes, thus I asked to the represants of olmesartan about this issue and wanted them to bring report about this issue if they have any. I'm still waiting, for 20 days.

 Lets assume that Marshall is right and benicar corrects VDR dysfunction. Please explaine me what happens after that. We have functioning VDRs and little amount of D3 in our bodies. Then what happens?

  yılmaz

  As we all know VİTD decreases NF-Kappa B activity.  We can also see at the Dr. Martin Pall's work that, NF-Kappa B causes increased secretion of IL-1B, IL-6, IL-8, TNF-alfa, IFN-gamma, all of which causes increased synthesis of NO by immüne cells. NO is protective against CPN infection but also give harm to healty tissue. If you get into a vicious cycle of NO/ONOO it may result in big harm. So VİTD would be helpfull in this situation to break down the vicious cycle at the cost of decreased immünity against CPN. If you are on a good antibiotic protocol that would make no problem. But ıf VİTD helps to patients taking no antibiotic we should find some other mechanisms.

 yılmaz

Quote from the indomitable Mackintosh:"I was struck by Yilmaz' comment, "As we all know..." and felt the need to jump in here. No, we do not "all know". I'm finding this conversation has become increasingly detailed and technical. After four years here, I find I cannot follow it, so I assume some others can't, either" 

I might have known that PGM would be behind this somewhere!  Carry on taking your vitamin D, everyone because you need it, especially those with MS who tend to be deficient.  I can't be doing with all the techno-speak, I have better things to do and I am doing them well after taking a minimum of 4000iu of the stuff even before I started CAP...........Sarah

An Itinerary in Light and Shadow

Yes, continue with Vit D - thanks to Red, we know the deficienty is rampant.  For me, it is like not realizing that my right arm was not working.  Though I am left-handed, I did not even notice - how can that be?  Only years later did I understand that brain-fog is also rampant - and can be deadly, causing you not to notice that your foundation is  beyond crumbling.

I received word this weekend that a dear friend has just been diagnosed with stage 3 ovarian cancer.  Her Vit D level is 23.

Rica

 I agree with MacKintosh that newbie would have have difficulty on understanding this discussion. But this site is a very scientific site and there are many other scientific discussions here. Newbies will have difficulty on understanding some other important issues like secondary porphiria, co-infections, cytokin reactions, endotoxin reactions etc. also.

 I also know that there are many other scientific and knowlegable people in this site. Even I am a medical doctor I leaned many thing from them. I'm thankfull to them. I believe many people in this site can follow this discussion ıf they want. 

 There are many articles saying that NF-KappaB is an important contributor to CPN infections and autoimmüne diseases like MS. We can find some of them at that link posted by Red.

 http://www.cpnhelp.org/vitamin_d_1

 That is another one and a very good one showing interactions between NF-KappaB, vitD3, curcumin etc.

 NephroPal: Inflammation and NF-kB -

 In this site there are some discussions which are builded up on personal experiences which is much more unscientific but we still get benefit from them.

  yılmaz.

  I think there is a misunderstanding here. There is nothing against VİTD use in my comment, but you can see just the opposite;

 ''So VİTD would be helpfull in this situation to break down the vicious cycle at the cost of decreased immünity against CPN. If you are on a good antibiotic protocol that would make no problem. But ıf VİTD helps to patients taking no antibiotic we should find some other mechanisms.''

 As far as I know almost all people here are under antibiotic treatment, so there is no problem. But we should find the mechanism how vit D3 helps to MS patients who doesn't take antibiotics. After reading all these Dr. Pall's work I did decided to restart VİTD3 again, and thinking to restart it for my son to decrease peroxynitrite damage.

 Sarah,there is no relation of PGM with this.

  yılmaz.

  yılmaz.

I would like to point out that this thread and conversation is not a forum topic, it is Blog Space that is listed under Yilmaz's user name.  From my perspective he is entitled to host whatever discussion, (within the boundaries of non-offensive contentl) that he may so choose to discuss, in whatever language he wants even if many of us may not understand or agree with the content.   

The beauty of Blog space is that the user gets to talk about whatever is of interest to themselves, they can even wipe out the entire blog at their own volition should the user chose to do so.

Yilmaz I am glad that you have decided to take VitD3 again!  Louise

 "Sarah,there is no relation of PGM with this."

Sorry, Yilmaz, I should have said "pgm" uncapitalised, who has posted Marshallite views on Vit D both in your blog and in other places.............Sarah

An Itinerary in Light and Shadow

  Lousie, thank you for your support, I realy need it. I started to feel that asif everybody in this site are against me:)).

 I am a kind of person who like the discuss all possibilities and if I have a questionmark on my mind I don't afraid to look for the answer. I don't want to be religious about anything if it's not proved especially.

 People in this site need encouragement so much and there are many encouraging people here. I'm gratefull to all of them.

 We also need people who ask questions and criticize to get closer the truth. Norman is one of them forinstance and evenif I get crazy about him sometimes I like him so much. I learned much from his critiques, he force me to investigate deeply.

 yılmaz.