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My sister has FMS and has been on azithromycin for a while. Although she has been improving on the abx she recently stopped taking it. She did so because she had heard (forgot to ask where) that azi doubled your chance of developing breast cancer. I have never heard that. Has anyone here heard that? I'd hate to see my sister give up on eliminating her FMS (and the potential other problems Cpn could cause her in the future) out of fear of developing cancer, especially if it's a myth.

Comments

 

Sunni, I haven't heard this either, but she ought to ask herself what are the risks of developing breast cancer in the first place?

This is the risk of developing breast cancer at any particular age:

  • Age up to 25: 1 in 15,000
  • Age up to 30: 1 in 1,900
  • Age up to 40: 1 in 200
  • Age up to 50: 1 in 50
  • Age up to 60: 1 in 23
  • Age up to 70: 1 in 15
  • Age up to 80: 1 in 11
  • Age up to 85: 1 in 10
  • It is taken from here:http://www.breakthrough.org.uk/about_breast_cancer/understanding_breast_cancer/lifetime_risk.htmlIf she is 40 she has a one in 200 chance of developing the disease, so if this did double the risk, it would still only be a one in one hundred chance: 1%, so not very much.  If she is 85, the chances chance to 1 in 10, but even there, most cancers are benign or slow growing even at that age.............Sarah

    An Itinerary in Light and Shadow

    Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

    It is certainly not true. http://cebp.aacrjournals.org/cgi/content/full/15/11/2102 Cancer Epidemiology Biomarkers & Prevention Vol. 15, 2102-2106, November 2006 © 2006 American Association for Cancer Research Antibiotics and Risk of Breast Cancer: Up to 9 Years of Follow-up of 2.1 Million Women Antibiotic use has been associated with risk of breast cancer in previous reports. Using Cox proportional hazards analysis, we evaluated this association in 2,130,829 adult female subscribers of a health care program according to their receipt of prescriptions of antibiotics from outpatient pharmacies. Hormone use was taken into account. Altogether, 18,521 women developed breast cancer in up to 9.4 years of follow-up. Use of any antibiotic was associated with slightly increased risk [hazard ratio (HR), 1.14; 95% confidence interval (95% CI), 1.10-1.18] but there was little, if any, evidence of dose response, with HR of 1.17 (95% CI, 0.97-1.42) for >1,000 days of use compared with no use. The only two weakly associated antibiotic groups (HR >1.10 for >100 days of use) were tetracyclines and macrolides with HRs (95% CI) of 1.23 (1.11-1.36) and 1.16 (0.98-1.36), respectively. An association of lincosamides with breast cancer in an earlier, smaller database was not confirmed, but follow-up was too short in the present data for adequate evaluation. Medical record review suggested that acne and/or rosacea could be the underlying factor, associated with long-term antibiotic therapy and found by others to be associated with risk of breast cancer. Although causality cannot be ruled out, the observed associations of antibiotics overall, tetracyclines, and macrolides with breast cancer were weak and could be explained by uncontrolled confounding by the diseases being treated or by other factors. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2102–6) We conclude that use of most antibiotics is associated with little, if any, increase in risk of breast cancer in up to 9 years of follow-up. Use of tetracyclines and, to a lesser extent, of macrolides, especially long-term use, showed evidence of a weak association, of uncertain causal significance. The underlying explanation may be an association of acne and/or rosacea with both use of these drugs and risk of breast cancer. Longer follow-up in the current data is needed to evaluate the association of lincosamides with breast cancer risk found in an earlier cohort. Their inclusion criteria

    Cured of multiple sclerosis, stopped the Wheldon's protocol in Nov,2008. Use only LDN.

    The important line from LifeontheIce's earlier post is:

    "We conclude that use of most antibiotics is associated with little, if any, increase in risk of breast cancer in up to 9 years of follow-up. Use of tetracyclines and, to a lesser extent, of macrolides, especially long-term use, showed evidence of a weak association, of uncertain causal significance."

    And I wish I could have responded as succinctly as Garcia did.  It was perfect.

    The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

    And I feel compelled to add my experiential but uneducated response: I have had a bi'lateral mastectomy and am about to undergo the last phase of reconstruction. I have also undergone four plus years of abx treatment for galloping PPMS. Tell you what - the choice is easy for me - do you mammograms, eat well, take all your meds. I'd much rather take "the cure" with all the attendent bad days than have PPMS.

    3/9 Symptoms returning. Began 5 abx protocol 5/9 Rifampin 600, Amox 1000, Doxy 200, MWF Azith 250, flagyl 1000 daily. Began Sept 04 PPMS EDSS 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

    I had lobular carcinoma insitu before starting CAP. Hasnt CPN been linked with breast cancer? I would definately take my chances.  if she is uncomfortable taking azith, she can switch to biaxin..

    Mphs, TN. CFS, hypoT (Hashi), adrenal fatigue, hormonal inbalance. right arm neuropathy-getting better. cpn, myco, EBV, CMV, HHV-6. Cap began in 6/07. NAC 2400mg, mino 100mg bid, biaxin 500mg bid. cytomel, flagyl bid continuously.

    Sharon, yes I think it has been linked to cancer, so damned if you do and damned if you don't.  At least I have control over ABX, I can decide to take them and I will continue because I want to get better.

    Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse.

    Don't worry guys

    > Use of tetracyclines and, to a lesser extent, of macrolides, especially long-term use, showed evidence of a weak association, of uncertain causal significance. The underlying explanation may be an association of acne and/or rosacea with both use of these drugs and risk of breast cancer

    Basically even they are saying that the chances are there is some underlying causal factor which causes people to use long-term abx, and which precipitates them to breast cancer. Chronic infection (e.g. with Cpn) would be the most likely causal factor. Bottom line is not that abx cause cancer, but that people who need to use abx have bugs that cause cancer. 

     

    Hunter: Don't think - experiment