27 Apr 2018

Antibiotic Combo


How affective is the INH, NAC or Amoxicillin, and Flagyl combo to get rid of CPN?My doc first started me on this protocol and said it was a pretty good one.  Has this been anyones experience?  Is it still used to get rid of CP?


From my limited inexpert knowledge it seems to be missing one antireplicative antibiotic.   We usually use two, doxycycline (or minocycline, or Rifampicin) and azithromycin (or roxithromycin).   However I think the your protocol is one that was used by the Vanderbuilt doctors a couple of years ago, maybe things have moved on.

The latest out of vanderbilt is the protocol that was recommended to Kimscupoftea, which is:


1)   Rifampin  

2)   Azithromycin  

3)   Metronidazole (generic for Flagyl) 15 on 15 off ,although Kim could not carry on past 7 days on.

4)   Sodium Pyruvate added after 8 wks.


Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse. Zoo keeper for Ella, RRMS, At worse EDSS 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse.

off subject--I assume your name "presacanario" is because you own one?? True??

linda m

If there is no wind..............row
New Hampshire USA on CAP since 2-4-2006 for MS Currently on doxy 100mg, 2x day, azithromicin 250mg, m,w,f and 500mg flagyl 3x a day for five days every three weeks.

If there is no wind..............row
12/26/2010 Presently not on any antibiotics. Just supplements. Started new LLMD 12/09/2010. Will start (12/30/2010?)150 mg Doryx after several test are done.

Info on Presa Canario :) -- interesting! http://www.hot.ee/presacanario/origin.html

Jeanneroz ~CPN 4/2007; HHV6, EBV, CFIDS/FM- diagnosed: 6/07; IBS, prior kidney infections, food allergies, hypothyroid (RAI for Graves in 1998), Adrenal issues; prior bronchitis/sinus problems. 200 mg/doxy daily & 250 mg AZITH M/W/F, supplmnts

JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

This may actually be the more effective of the protocols, as the INH was found in the lab to clear macrophages faster than anything. I noted that in Astrodiana's more thorough report of her protocol on a CFS site, she did not take flagyl but did take the doxy/azith combo but plus the INH. I too would want one more abx in it, and if I could manage it would take Rifampin--- although both Rifampin and INH have to be monitored for liver stress. The more I hear, the more I believe that a lot of us would have more rapid improvements with these, if we can handle them! 

CAP for Cpn 11/04. Dx: 25yrs CFS & FMS. Protocol: 200mg Doxy, 500mg MWF Azith, Tini 1000mg/day pulses; Vit D1000 units, Cytotec 100mg, Plaquenil 100mg, Magnascent Iodine 12 drps/day, T4 & T3


You beat me to it.  I was going to ask if there were any speculations as to how Astrodiana came out on top with out the addition of Flagyl?

My conclusion was INH as like you say, it clears macrohages fast.  This has been my experience and I love INH.  It's definitely easier on me then Flagyl er se. I can't wait to harness the torture of Rifampin next.  Serrepeptase(enzyme) has also helped tremendously for better perfusion(sp) of the microbials

Presacanario, does your Abx provider follow your complete metabolic profile?  If so have you had any elevations.  And what does he consider reasonable elevations to tolerate? 

Why do you love INH, like what subjective experience do you have to share about your improvement on it?  have you done the Doxy, Roxi, (azythro), Flagyl route for any length of time for comparison?  No criticism here intended just wanting to learn about applied options and subjective effects.  Also are you in the MSer dx group or the Other Dxs group.  I cannot reacall exactly.  I think the other dx group but .... Thank you so much for your questions.  Louise


Started6/24/07WheldonCAP. OnDoxy, NAC Roxi, Tini 2 /3/08TiniPulse#4 completed.  Cholestyramine 2 packets at Bedtimefor  PorphoriaandDie-offSymptoms Of Fatigue, Brainfog, MoodDisturbances, BalanceFromApoptosis.

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

 In the original Vanderbilt patent studies, INH was the most effective and fastest at clearing the macrophages (I think it was of infected mice). It still is not active against cryptic form. I notice it is missing from my signature, but the addition of 150mg INH when I started with Dr. Powell really helped me get to a new level of improvement, although it took a month or two to get through the extra die-off and notice the improvement. I continue to take 150mg daily. Took the whole 300mg dose for a month but had to stop as I got real depressed on it after 3 weeks. Don't know why, as no one else has reported this except from flagyl, which I also got depressed on after 6 weeks.

CAP for Cpn 11/04. Dx: 25yrs CFS & FMS. Protocol: 200mg Doxy, 500mg MWF Azith, Tini 1000mg/day pulses; Vit D1000 units, Cytotec 100mg, Plaquenil 100mg, Magnascent Iodine 20 drps/day, T4 & T3