Probably, by the time you have found your way to our site, it's too late to enter this clinical trial of minocylcine as they only want the recently afflicted. Nevertheless, it's nice to know that they are doing it. It was Calgary's initial experiments with mino that induced my neuroi to suggest it to me. Yay Calgary!
http://www.clinicaltrials.gov/ct2/show/NCT00666887?term=minocycline+%2BM...
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PPMSii-misdiagnosed 2001-diagnosed 2006. Also maybe csf and Lyme -- who knows?! Minocycline 7 mos.- resulting bronchitis 5 months. Deserted by Hopkins neurology dept. and going to private md. out-of-plan. Wheldon CAPii 3/2/07 - Now (1/10) doing 100 doxyii; 125
Doesn't anyone find this
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PPMSi-misdiagnosed 2001-diagnosed 2006. Also maybe csf and Lyme -- who knows?! Minocycline 7 mos.- resulting bronchitis 5 months. Deserted by Hopkins neurology dept. and going to private md. out-of-plan. Wheldon CAPi 3/2/07 - Now (1/10) doing 100 doxyi; 125
I hadn't read it Nancy.
I hadn't read it Nancy. Did you read my post regarding LDNi Books? More and more it seems to me that the old crew is reading and commenting less and less. Guess that's just the way things tend to progress overtime.
Yes it is great that there is some investigation regarding the use of Minocycline as a long term monoabx therapy. When will the study start and how long is it anticipated to run and to be completed. What is the goal of the study? Louise
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6-07WheldonCAP CPnBb FMSi-CFS20+yr, 11-07Cholestyramine HSPRNx7d-porphyrin+endotoxini
3-08Iodoral, 5-08BHRT, 8-08Same+Bs, 10-08D-10,000IU
2-09Intermit-CAPDoxi
RoxiClari,Tinii, 2-09LDN-CFS1-10-IT+Ursodiol300Bid+Lauricidin
Louise, as I recall, the
Louise, as I recall, the study is recruiting now and each participant will commit to 2 years. They are taking 280 applications with the intention of having 200 participants, half on placebo. If you click the link you will find it very clearly delineated. It runs through 2015.
Let's hope that the oldtimers are so healthy that they are just too busy to read much online. Or maybe they're just hiding out. I check in regularly now that I am at home and have a computer (I was hospitalized and in a rehab facility for 6 weeks) but I'm often too tired to read much. So no, I haven't read your forum about LDNi yet. My doc just told me not to resume the LDN because the only time it gives me energy is at 1 a.m.
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PPMSi-misdiagnosed 2001-diagnosed 2006. Also maybe csf and Lyme -- who knows?! Minocycline 7 mos.- resulting bronchitis 5 months. Deserted by Hopkins neurology dept. and going to private md. out-of-plan. Wheldon CAPi 3/2/07 - Now (1/10) doing 100 doxyi; 125
I spoke with a reputable
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6-07WheldonCAP CPnBb FMSi-CFS20+yr, 11-07Cholestyramine HSPRNx7d-porphyrin+endotoxini
3-08Iodoral, 5-08BHRT, 8-08Same+Bs, 10-08D-10,000IU
2-09Intermit-CAPDoxi
RoxiClari,Tinii, 2-09LDN-CFS1-10-IT+Ursodiol300Bid+Lauricidin
I suppose that I am an old
I suppose that I am an old timer and my excuse is that I have been so busy I have only just seen the post. Not to mention our rare Brit heatwave, so I'm hiding out as well!
There has been a Metz trial using minocycline in Canada before, but I'm awfully afraid that it is only interested in the immunomodulatory powers of minocycline, so I am sure that as soon as a non antibiotic minocycline is developed they will use that instead. Of course, when this happens and they find people aren't benefiting from it so much anymore, they might have a change of opinion: you never know.
In the meantime, there is a sticky in the Antibiotics forum of ThisisMS, devoted to minocycline. It was started in 2005, so trials are as slow to get off the ground as "real" abxi ones...............Sarah
An Itinerary in Light and Shadow
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Its interesting yes
Its interesting yes ofcourse. Here is another study as well.
See article here : http://www.ncbi.nlm.nih.gov/pubmed/17463074
Note that the study is designated as " safe"
The results are obvious yet, still so many MS clinics and DR's are instead prescribing a drug that has already killed 7 and counting.
In my opinion minocin probably works best because its 2-4 times more effective than doxyi, it crosses the blood brain barrier easier and its much less likely to breed resistance. The problem seems to be tolerating it at such doses. Unfortunatly for most with CPNi, as possibly some other stealth pathogens the accelerated die off toxicity is too difficult to endure
I must say though, if i could handle it, I would use it instead of doxy, but it made me incredibly ill and unfortunatly its not an option for me.
Thank you for posting this because I just spoke to one of the contacts for one of the participating clinics near me. I knew I couldnt participate though because I have had MS too long and I already fulfill the macdonald criteria plus I cant tolerate the drug anyway.
I thought however it might be a good idea to switch to one of these clinics as opposed to my current clinic. I figure if these clinics are open to the idea of using antibioticsi then the dr's cant be all that stupid. The woman who i spoke to, very nice i might add, ( which should reflect the climate of the clinic ) did tell me that they are focusing on the immodulary properties of the drug in preventing the " immunei system from attacking itself " ok that ;) , but nevertheless, the clinics participation does suggest a degree of openmindedness which means that its probably a better place for me in regards to an ongoing neurologist.
She also mentioned that this is a physician initiated study not a drug company funded study. Well Ofcourse!
Thanks for the info artile, If I go to this clinic, I hope to try to raise awareness to the idea that minocin is actually treating infection and the immodulary property is secondary and it may even be a result of the infection being treated and the response of the immune ststem to eradication of the pathogen.
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MSi TMJ trigeminal neuralgia
cfsineutropeniacystitisnephritisoptc-neuritissinusitis. Dox200 zith250 rif 600 daily. Treating cpn and TBI'sWhat about this
What about this link?
http://www.telegraph.co.uk/health/healthnews/6261688/Cheap-antibiotic-could-revolutionise-stroke-treatment.html
here is the research paper
http://www.biomedcentral.com/1471-2202/10/126
What about this
What about this one?
http://www.bio-medicine.org/medicine-technology/Treatment-with-Copaxone-Plus-Minocycline-Showed-Substantial-0AReduction-of-Disease-Activity-in-Patients-with-Active-0ARelapsing-Remitting-Multiple-Scl-782-1/