Clinical Outcomes: a small data-set

D W

Clinical outcomes. Here is a summary of the clinical outcome of treatment on the ten patients seen in my laboratory, with established progressive MS (or progressive neurological illness with MS-like features.) The diagnosis of MS was made at consultant neurologist level.

10 patients were seen and received treatment and were followed up.

In 7 of these progression of the disease was halted.
In all 7 there was some resolution of symptoms.
In all 7 resolution continues.
6 of these 7 patients had cognitive deficits; these were reversed in all 6.

In 3 of the 10 patients progression continued despite 6M treatment.
In 1 of these patients there was little doubt over compliance with medication.
In 2 of these patients compliance with medication was doubtful.

Acute relapse was seen in no patient.

It is a very small number. It includes only those patients seen and followed up on at least three occasions by myself, so does not include self-reporting or anecdotal cases. (It should be borne in mind that the natural history of progressive disease is towards deterioration: although there may be plateaux of stability, the likelihood of a spontaneous global remission is very slim.) David

Thank you, David.  The part I like best is "In all 7 the resolution continues".   The part I am sorry about is so little faith, so little compliance.  Personally, I have other things I would rather do, but the trade-off is  -  let me see, should I make a list beginning with thinking, dressing, swallowing, walking..........17 months, every day  and my list continues to grow.

Rica 

Ignorance is voluntary bad luck.  Lauritz S.   A true Viking

If you come to a fork in the road, take it. Yogi Berra

3/9 Symptoms returning. Began 5 abx protocol 5/9 Rifampin 600, Amox 1000, Doxy 200, MWF Azith 250, flagyl 1000 daily. Began Sept 04 PPMS EDSS 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

 David- Thanks for posting this. Really important to have actual data sets available. So many of us "in process" here that it's hard to stand back and know how powerful this work is. These results are unheard of for MS. Guess this isn't just a pet theory, huh? This goes in the Handbook!

On Wheldon/Stratton protocol for Cpn in CFS/FMS since December 2004.

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Here is a very interesting and very positive 9-month-long trial for spondyloarthropathy in which chlamydial involvement was suspected. Doxy alone did very little. The patients in the "real" treatment arm, doxy plus rifampin, saw ~2x reductions in multiple measures - pain (visual analog scale), morning stiffness (hours), tender joint count, swollen joint count.

J Rheumatol 31.10.1973-80, 2004.

I think there are also some negative trials out there for a similar patient population. One would want to examine whether the regimes used in such trials might simply have been far too weak.

More great news - thank-you so much for the report!

 

 

 

On Wheldon protocol for MS since April, 2006.  LDN 1994

5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tini pulses,100 mg diflucan, 4.5 ldn; Wheldon protocol for MS April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.