Clinical outcomes. Here is a summary of the clinical outcome of treatment on the ten patients seen in my laboratory, with established progressive MSi (or progressive neurological illness with MS-like features.) The diagnosis of MS was made at consultant neurologist level.
10 patients were seen and received treatment and were followed up.
In 7 of these progression of the disease was halted.
In all 7 there was some resolution of symptoms.
In all 7 resolution continues.
6 of these 7 patients had cognitive deficits; these were reversed in all 6.
In 3 of the 10 patients progression continued despite 6M treatment.
In 1 of these patients there was little doubt over compliance with medication.
In 2 of these patients compliance with medication was doubtful.
Acute relapse was seen in no patient.
It is a very small number. It includes only those patients seen and followed up on at least three occasions by myself, so does not include self-reporting or anecdotal cases. (It should be borne in mind that the natural history of progressive disease is towards deterioration: although there may be plateaux of stability, the likelihood of a spontaneous global remission is very slim.) David
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D W - [Myalgia and hypertensioni (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazoleii. No medication now; just supplementsii and IR sauna. Morning BP typically 105/75]
Thank you, David. The
Thank you, David. The part I like best is "In all 7 the resolution continues". The part I am sorry about is so little faith, so little compliance. Personally, I have other things I would rather do, but the trade-off is - let me see, should I make a list beginning with thinking, dressing, swallowing, walking..........17 months, every day and my list continues to grow.
Rica
Ignorance is voluntary bad luck. Lauritz S. A true Viking
If you come to a fork in the road, take it. Yogi Berra
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Rica PPMSi EDSSi 6.7 at beginning - now 2. Began CAPi Sept, 2004 with Rifampin 150 mg 2xd, Doxyi 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyli total 55 pulses LDNi Rifampin 8/08 again NC USA
Wonderful news, David.
 David- Thanks for posting
David- Thanks for posting this. Really important to have actual data sets available. So many of us "in process" here that it's hard to stand back and know how powerful this work is. These results are unheard of for MSi. Guess this isn't just a pet theory, huh? This goes in the Handbook!
On Wheldon/Stratton protocol for Cpni in CFSi/FMSi since December 2004.
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CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3
Here is a very interesting
Here is a very interesting and very positive 9-month-long trial for spondyloarthropathy in which chlamydial involvement was suspected. Doxyi alone did very little. The patients in the "real" treatment arm, doxy plus rifampin, saw ~2x reductions in multiple measures - pain (visual analog scale), morning stiffness (hours), tender joint count, swollen joint count.
J Rheumatol 31.10.1973-80, 2004.
I think there are also some negative trials out there for a similar patient population. One would want to examine whether the regimes used in such trials might simply have been far too weak.
Here is the link for the
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LDNi since 2-04, Wheldon/Stratton protocol 4-06
More great news - thank-you
More great news - thank-you so much for the report!
On Wheldon protocol for MSi since April, 2006. LDNi 1994
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On Wheldon protocol for MSi since April, 2006. doxyi 200 mgs daily, zithromax 250 mgs 3x/ week , Flagyli Pulses start end Sept., LDNi 2004. Gad-enhanced MRI of brain and spine shows NO NEW DISEASE ACTIVITY and one lesion diminishing in size on 9/30. Ma