Cholestyramine and Thyroid Meds

 For those who are taking Cholestyramine and Thyroid meds:

“Cholestyramine: Cholestyramine binds both T4 and T3 in the intestine, thus impairing absorption of these thyroid hormones. In vitro studies indicate that the binding is not easily removed. Therefore, 4 to 5 hours should elapse between administration of cholestyramine and thyroid hormones.”


Were you aware of this?   I'm getting ready to pulse and was thinking about asking my doctor for Cholestyramine... so my inquring mind did a google search and ran across this. For what its' worth... Jeanneroz 

 Well, it binds a lot of things, but I would be really surprised if it gets to thyroid meds which have been:

  1. taken hours before,
  2. mostly absorbed in a couple hours,
  3. and seperated in the intestine by a meal which would keep the cholestyramine sequestered into a different space in the intestines.

Ask your pharmacist or doc whether they know the absorbtion profile of the thyroid meds you are taking and whether this is likely to be a problem. I have not noticed any reduction in effect of my own thyroid meds when I take the cholestyramine. 

Can you give the page link for your quote? 

CAP for Cpn 11/04. Dx: 25yrs CFS & FMS. Protocol: 200mg Doxy, 500mg MWF Azith, Tini 1000mg/day pulses; Vit D1000 units, Cytotec 100mg, Plaquenil 100mg, Magnascent Iodine 12 drps/day, T4 & T3


CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Jim.. sure, here's the link.  I actually was checking on Cytomel and noticed the interaction with cholestyramine.   The paragraph I quoted is the fourth one under "drug interactions"

My doc and I added T3 to my thyroid this past week....... as of today, I just discovered I have a "bad lot"  of Armour!  Geesh... no wonder I have felt like hell since my last script got filled AND I'm sure the thyroid panel I had done on Thursday is worthless, LOL because of the meds.  This happened one other time, many years ago.  I still prefer armour over synthroid any day though! 

Oh, well, I guess that's why we empower ourselves (to find information like that ).

Jeanneroz ~CPN  4/2007; HHV6, EBV, CFIDS/FM- diagnosed '07; IBS, prior kidney infections, food allergies, hypothyroid (RAI for Graves in 1998), Adrenal issues (hypo); prior bronchitis/sinus problems. 200 mg/doxy daily & 250 mg AZITH M/W/F, supplement

JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

 I had posted a question on chole a while back. Jim has listed out several drugs that chole binded with. I am about to leave. Tomorrow I will go and look for the thread...Jeanne, one of the drugs I remembered was progesterone..

Mphs, TN. CFS, hypoT (Hashi), weak adrenals, 37 w/hormones of 80 yo. right arm neuropathy. + for cpn, myco, EBV, CMV. on NAC 3600mg, doxy 100-2xday, azith 250 m/w/f, estriol, progesterone, synthroid, and pulsing w/flagyl.

Mphs, TN. CFS, hypoT (Hashi), adrenal fatigue, hormonal inbalance. right arm neuropathy-getting better. cpn, myco, EBV, CMV, HHV-6. Cap began in 6/07. NAC 2400mg, mino 100mg bid, biaxin 500mg bid. cytomel, flagyl bid continuously.

Well Jeannie, that is very interesting.

Pharmacists are pretty good about drugs & interactions.  Sooo sorry you got a bad batch of armour!!

You will be feeling better soon!

CFIDS/ME 25yrs, FMS, IBS, EBV, Cpn, (insomnia - melatonin, GABA, tarazadone, triazolam, novocyclopine, allergy formula, 3 gm tryptophan), Natural HRT peri-M, NAC 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, 1-3-08 5th pulse 1 X 375 mg 4day

CFIDS/ME, FMS, MCS, IBS, EBV, CMV, Cpn, H1, chronic insomnia, Chronic Lyme, HME, Babesia, Natural HRT-menopause, NAC 2.4 gm,Full CAP 6-2-07, all supplements+Iodorol, Inositol-depression, ultra Chitosan, L lysine Pulse#27 04-19-10 1gm Flagyl/day-5 days<