Submitted by Jim K on Wed, 2005-08-31 20:44

POTENTIAL ROLE OF CHLAMYDIA PNEUMONIAE IN THE PATHOGENESIS OF INTERSTITIAL CYSTITIS. Gregory L. Alberts, Charles W. Stratton, William M. Mitchell, Jenny J. Franke. Vanderbilt University School of Medicine, Nashville, TN

INTRODUCTION: Chlamydia pneumoniae is now recognized as an important human pathogen. As an obligate intracellular parasite, it is difficult to detect by routine cultures, can cause chronic infections, and may not elicit an acute inflammatory response. C. pneumoniae is commonly associated with respiratory tract infection, but has also been implicated in the development of coronary artery plaques and chronic inflammatory conditions such as multiple sclerosis. Our recent data using polymerase chain reaction (PCR) analysis of urine revealed that 71% of patients with interstitial cystitis (IC) were positive for C. pneumoniae. These data suggest a potential role for this organism in the development of IC. We present our data using tissue culture detection of C. pneumoniae in both control patients and patients with interstitial cystitis to further investigate this association.

My disease started with just IC, and my doctor who was really great, ran about every piece of bloodwork on me that she could think of, because she had no idea what else to do. she is the first person to pick up on CPN, and she just thought it was "peculiar" that my titers were so high. however, she didn't know how to treat it, so gave me 3 weeks of doxy and thought that would be good enough. I was not sick for a year and then developed CFS, and then all of my viral titers were high. and now i'm on the CAP, but i wonder if maybe i had stuck with a real CAP when I just had IC (which is horrible and scary by the way, i'm sure a lot of people here have dealt with it) I may have never developed CFS. Jenny to answer your question, IC is basically another diagnosis of exclusion. The symptoms wax and wane a lot but if you feel as though you pretty much constantly have a bladder infection, but nothing shows up on the culture, they will eventually dx you with IC.

Gearing up to starting abx protocol from Dr. powell. Initial diagnosis of Interstitial Cystitis (july 06), progressed to all over falling apart syndrome within the past year. Current supplements/meds: sublingual B12, ursodiol, Niacin, NAC 1200 m

Many doctors think conditions like interstitial cystitisi and vestibulitis are not infectious because they fail to culture pathogens. Angela Kilmartin in Britain and Dr. Fugazzotto in South Dakota test the urine of patients with interstitial cystitisi and find infection other labs miss. They frequently find mycoplasm other labs had missed. Also mycobacteria from hot tubs and swimming pools may cause it. Chlorine won't treat water for that, and there isn't much in the way fo a lab test for mycobacterium. (Note it is different from mycoplasma, and is difficult to treat.)

minocycline, azithromycine, metronidazole 2007-2009, chelation for lead poisoning, muscle pain, insomnia, interstitial cystitis (almost well), sinus, dry eyes, stiff neck, veins, hypothyroid, TMJ, hip joints (no longer hurt)

I suppose you know a lot more than I do about IC, however a friend of mine gave me this website where his some gets support and information and I offer it to you in case you have no come across it.   There are a number of people here who suffer from it, and many others who have lesser bladder symptoms.   Cpn can be the cause of this problem.

Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse.

Jim, thanks for publishing this. So many times, when a Doctor gets south of the belly button, the tendency to think of "Chlamydia" only as C. Trachomatis gets even worse. Of course, Aussie doctors do the same thing, only going Northwards.  I don't know what doctors do at the equator.  Ron

RonOn CAP for CFS starting 01/06 (NE Ohio, USA)Began rifampin trial 1/14/09Currently: on intermittent