MediTest
27 Apr 2018
Author
clammed_up
Title

cephlosporins

Body

Hello, a quick questionDo 3rd generation cephlosporins have any effect on chlydmia pneumoniae ?

Comments

Clammed - to my knowledge 3rd generation cephs such as Rocephin/ceftriaxone do not have activity against gram negative intracellular pathogens such as chlamydia or mycoplasma, legionella, etc...

Here is the PI for Rochephin - pages 4 and 5 has the antibiotic sensitivity testing results. 

http://www.rocheusa.com/products/rocephin/pi.pdf

 Also from the Rocephin PI see lines 258 on  bottom of page 9- regarding Chlamydia trach in PID .

Also - Dr. Stratton does not reference any testing on CPN with cephalosporins in his patent.

Based on mechanism of action of cephs it would make sense to me that they would not work in CPn.

Hope this helps.

Daisy - Husband on CAP 5/07.   Roxy, Diflucan round three 4-4, Rifampin, Bactrim DS, Mepron 4-6, Prednisone, Novantrone, Doxy, Azithromycin, Flagyl, Mino

Daisy - Husband on CAP 5/07.  Husband died from Acute Myelogenous Leukemia Secondary to the Infusion of Novantrone.  Ie - the treatment with the conventional MS drugs killed him. Daisy on her own CAP 11/2012. 

I wish that I knew, since it is not part of the Cpn protocol. Took 2gms day/10 days of Keflex, followed by 1 gm IV Rocephin for 6 days for cellulitis in a toe. Developed severe neuropathy that kept getting worse and worse.in the month, since. Haven't been able to leave my home. Just now finding a little relief from use of Welchol and charcoal. soon to begin Bentonite clay. Don't know what to think. Is it die-off from Cpn or is it from Lyme? Or is it from something else? Just don't know.

 

RRMS, diagnosed 2/04. NAC 4/06. Started Wheldon/Stratton regime 8/30/06. Doxycycline, 8/06, Azith, 10/06. Switched to Roxithromycin 11/06. Psuedo relapse/die-off with hospitalization 1/07. GAD-enhanced MRI of brain and spine shows NO NEW DISEASE ACTIVITY. LDN 4/07. 1st Tinidazole Pulse, 8/11/07. Keflex 2/08. IV Rocephin 3/08. USA

Daisy you are a good woman! Thank you soo much. This is eactly what I was looking for. I sense you see where Im going with this.

Minai 2 questioons is thats ok?

Have you ever taken penacillin, amoxicillin or ampicillin and if you havnt... are you penacillin allerrgic?

When you took the keflex and rocephin were you still on the cap bacteriostatics as well or diod you go off them?

Thanks both of you ~

     &nbs

Hi Clammed,

 

 

No. Am not allergic. I took Penicillin years ago with no problems. Have been taking Doxy and Roxy (both macrolides) for over a year and a half with no problems, either.

 

 

 Yes. Was still on CAP when I took the Keflex and Rocephin. Have been off all ABX temporarily for over a month, until I stop suffering from the neuropathy so badly. Just started drinking Bentonite clay to soak up some of the endotoxins and it is definitely helping, so far.

 

 

Here is something that was just sent to me about Ceftriaxone(Rocephin) kiling both gram negative and positive bacteria in cases of pneumonia: LINK

 

 

--Minai

 

 

P.S. Would definitely heed what Michele and others say about which meds and how much to be taking. Straying from the protocol is what caused my problems

 

 

P.P.S. Had the same exp with an ER doc. Think it's because they know that they are isolated by ER work in not being held accountable in treating patients long-term. They're actually nice because of it

Minai - Good article on pneumonia.    Still don't believe that cephalosporins work for Cpn though. 

It is true that cephalosporins will work on some gram negative bacteria but they are not believed to work on the gram negative intracellular ones like mycoplasma, CPn and legionella for example. 

Here's quote from study you linked "Concomitant treatment with erythromycin or metronidazole was allowed when infection with Legionella pneumophila, Mycoplasma pneumoniae, Chlamydia pneumoniae, or a cephalosporin-resistant anaerobic organism was suspected."

Usually in a hospital setting where they are giving IV 3rd generation cephs for someone with pneumonia they will also add a quinolone or macrolide to cover the gram neg intracellulars.

Same is true in outpatient setting.  I have seen many doctors give a IM shot of Rocephin in the office and then prescribe a round of macrolides to go home on.

I am thinking your severe reaction to the recent IV cephs (and hope you are feeling better and better everyday!) was a die off of something else besides CPn.

Daisy - Husband on CAP 5/07.   Roxy, Diflucan round three 4-4, Rifampin, Bactrim DS, Mepron 4-6, Prednisone, Novantrone, Doxy, Azithromycin, Flagyl, Mino

Daisy - Husband on CAP 5/07.  Husband died from Acute Myelogenous Leukemia Secondary to the Infusion of Novantrone.  Ie - the treatment with the conventional MS drugs killed him. Daisy on her own CAP 11/2012.