MediTest
27 Apr 2018
Author
Minai
Title

CD57

Body

For those of you who have been tested for CD57:  LINK  What were your results? Have you ever tested positive for Lyme, too? I never have (though some test results are still pending). Yet, my result is 72. And, that's after being on CAP for 2 years, now: >200 is normal < 20 severe illness 0-60 is seen in chronic Lyme disease > 60 Lyme activity indicates improvement   RRMS, diagnosed 2/04. NAC 4/06.

Comments

For those of you who, like me, haven't got a clue what CD57 means, here's a bit of what is on the link. Bear in mind the site IS a commercial website.

From Health Cnters of America website: "Our ability to measure CD-57 counts represents a breakthrough in Chronic Lyme Disease treatment. It can be used to help determine how active the infection is, how well the treatment is working, and whether, after treatment ends, a relapse is likely to occur!

This is how it works: Chronic Lyme infections are known to suppress the immune system. The Lyme spirochete can affect all major cell types of the immune system, but it most clearly can impact a specific subset of the natural killer cells. This is called the CD-57 subset. Just as in HIV infection, which suppresses T-cell counts, Lyme suppresses Natural killer cell count such as CD57."

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

My husband's first CD57 was actually 57.

Daisy - Husband on CAP 5/07.  Husband died from Acute Myelogenous Leukemia Secondary to the Infusion of Novantrone.  Ie - the treatment with the conventional MS drugs killed him. Daisy on her own CAP 11/2012. 

Its one of those cases where it would have helped if you had been tested before starting abx to know what you measured then.  If you had measured between 0-60, you have improved from that, so I guess the only thing is to wait until your doc next sees fit to have you tested again, to see what the results are then. 

Incidentally, I always feel a bit wary of serious medical sites which use exclamation marks..............Sarah 

An Itinerary in Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

My first test (before CAP) was an impressive 13.

After a year or so, it was up to 52.  I've still got a long way to go!

Positive Cpn and Bb dx'd November 2006.  Previously dx'd RRMS May 2000.  Treated by Lyme MD as of 11/06.  Current regimen is tetracycline, Difllucan and Mepron.

  

The link that I provided was sent to me by my LLMD. Am guessing that it was because it provides simple explanation to what CD57 is. And, his reasoning for testing.

 

HERE is a PubMed link. And, HERE is a link to a Lyme website that provides more info, including how to get tested for it; which labs to use; and how much it might cost. LabCorp did perform my test. And, insurance did cover it.

 

Can’t help but wonder if/how Cpn and other pathogens may be effecting CD57 levels, too. Yet, it appears that Lyme is the only one that’s been studied?

 

Daisy thanks for providing your husband’s lab value. Am assuming that test was performed after he had started ABX.

 

Wow, Deborah…before and after values! Maybe a predictor of how long you might have to remain on treatment? We may be talking more years than CAP is typically recommended for. Sarah is right…you and/or your doctor were wise to obtain the “before” value. Thanks for providing your info.

   

RRMS, diagnosed 2/04. NAC 4/06. Started Wheldon/Stratton regime 8/30/06. Doxycycline, 8/06, Azith, 10/06. Switched to Roxithromycin 11/06. Psuedo relapse/die-off with hospitalization 1/07. GAD-enhanced MRI of brain and spine shows NO NEW DISEASE ACTIVITY. LDN 4/07. 1st Tinidazole Pulse, 8/11/07. Keflex 2/08. IV Rocephin 3/08. IV Clindamycin 5/08. USA

 

I have now found my cd57 results from Labcorp dated 12/04/06 and requisitioned by my first american LLMD.

 

Abnormal findings :CD57+lymphs  result 42 described as low , ref. range interval 60  -360. All else is in normal range.

Please explain. I remain brainfogged.

 

Thank you so much, as always,

Loulou

diagnosed MS Jan.2000 ,  chronic neurological lyme disease Nov.2002.doxy 100 mg. 1BID. roxy.150 mg.? BID,adding rifampin soon, pulsed tini. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDN),NAC, nystatin, major wheldon supplemrnts daily,

  

Loulou,

 

Thank you for sharing your result.

 

According to the information on the links that I posted, CD57 measures how compromised one’s immune system, who is infected with Lyme, might be. The lower the value, the more compromised it is. After antibiotic treatment is started, it is used to monitor how well treatment is working to raise the CD57 level. The higher the level, the better (see links).

 

Yes. Yours was low. As you continue treatment, hopefully it will result in higher values. Even after 2 years on CAP, mine is only in a low normal range. So, probably no rush to be tested, again, anytime soon. Will just continue with CAP for at least another 2 years.

   

RRMS, diagnosed 2/04. NAC 4/06. Started Wheldon/Stratton regime 8/30/06. Doxycycline, 8/06, Azith, 10/06. Switched to Roxithromycin 11/06. Psuedo relapse/die-off with hospitalization 1/07. GAD-enhanced MRI of brain and spine shows NO NEW DISEASE ACTIVITY. LDN 4/07. 1st Tinidazole Pulse, 8/11/07. Keflex 2/08. IV Rocephin 3/08. IV Clindamycin 5/08. USA

 

 

Minai, My CD 57 after 16 weeks on high dose doxy (400mg/day) was 33.  That was about a year ago and  I have not had it read since.   Louise

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

So much for doxy, howwever, you never had a diagnosis os lyme or MS if memory serves me correctly. What does all this mean? I wish I knew?

diagnosed MS Jan.2000 ,  chronic neurological lyme disease Nov.2002.doxy 100 mg. 1BID. roxy.150 mg.? BID,adding rifampin soon, pulsed tini. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDN),NAC, nystatin, major wheldon supplemrnts daily,

Loulou, Bb (Borrelia Burgforferi) is official abbreviation for the disease called Lyme Disease.  Just as CPn is the abbreviation forChlamydia Pneumoniae, Bb in my signature says that I have been Dx with Lyme and the 33 results at 16 weeks of high dose doxy treatment shows that short courses of Abx are not enough to irradicate it from the body.  The abreviation is in my signature because the signature is very limited in length and cuts off after just so many characters are written when you type your signature in.  I

t would be really good if you would update your siganture with your current treatment protocol then we would know what your are doing.  

Hope that helps you understand my last post.

Louise

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Wow, Louise! It was probably even lower than 33 before the short-term Doxy. Hopefully, you'll eventually test higher with long-term CAP treatment. Thanks for sharing.

 

 

RRMS, diagnosed 2/04. NAC 4/06. Started Wheldon/Stratton regime 8/30/06. Doxycycline, 8/06, Azith, 10/06. Switched to Roxithromycin 11/06. Psuedo relapse/die-off with hospitalization 1/07. GAD-enhanced MRI of brain and spine shows NO NEW DISEASE ACTIVITY. LDN 4/07. 1st Tinidazole Pulse, 8/11/07. Keflex 2/08. IV Rocephin 3/08. IV Clindamycin 5/08. USA

Minai, Thanks for the ranges for the results of the test.  That was something that was lacking in my lab report.   It has been 11 months since that test was drawn.  I really have no need to repeat it until I think I might want to go off CAP continuous.  With Bb, intermittent is not something that I will be rushing to start even though I am feeling better now than I have in the past 5 years for the most part.  I know I am on for the long haul 3 - 5 years or perhaps more.  It is more important to me to feel well and have a life than to worry about being on long term abx.  I head the warnings, purchase VSL#3 probiotics that are doing well for me and take my supplements as suggested on the Wheldon variation of CAP and have added the simple methylation protocol  and intermittent cholestyramine as needed if I begin to notice any of the porphoria symptoms entering into my experience.

I have had no obvious neurological imparement except perhaps heat induced fatigue.  So my dx stands at CFS with FMS in remission. 

I hope you newly defined diagnosis brings a successful treatment plan and life improvements.

I will be following your blogs.  Thanks for sharing your ups an downs.    Louise

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

thanks for the info,

In Jan.06 my natural killer cells were low & I was positive for Lymes.  I don't recall the test for the cells to be CD-57 though.

I see my doc next week & will review my results again from that time.  I have really been questioning the strength of my immune system.  I can gauge it with my Herpes I.  When I get stressed my maintenance dose of L Lysine doesn't keep it in check.  With all the supplements I take one would think the immune system would be OK.???

We really don't know alot about these bodies, there is so much more to learn!

 

peace

r

CFIDS/ME, FMS, MCS, IBS, EBV, CMV, Cpn, H1, chronic insomnia, Chronic Lyme, HME, Babesia, Natural HRT-menopause, NAC 2.4 gm,Full CAP 6-2-07, all supplements+Iodorol, Inositol-depression, ultra Chitosan, L lysine Pulse#27 04-19-10 1gm Flagyl/day-5 days<

Hello all. I am currently seeing an internalist who sort of is known for lyme treatment and so we drive an hour to see him:) I have not kept him completely in the loop (he does not have the best bedside manner) but he tested me for cd57 and I was I think like a 52 or 56 I can't remember exactly- but it was in the 50's. I did the igenix test and it showed two iffy's and one strong positive - the one that crosses over with ebv - which I had a VERY strong off the chart case of mono in Feb of this last yr. Well, he still thinks it is lyme along with cpn- which I had no sign of current infection show on the test but past antigen level (i can never remember if that is igg or the other one-anyways) was like 247 or something really high. So- I have testing positive for CMV (fairly high), EBV, hh6 (old I think- not current), mycroplasma pneum (i dont think that one is current either), and then he thinks lymes as well. I am wondering if I shouldn't be testing regularly to see what my levels are doing. All of my CBC;s so far and I have had more than a few in the past 10 months- have all been normal except for the cd57 titer. My internalist basically told me to look at this website adn then to start on the NAC and then on amoxycillin- which I have been on NAC for 3 months and amoxycillin I am ending my second month's worth. I have had some reoccurance of symptoms (cardiac-fast hearbate, hard heartbeat, dizzies, brain fog, etc) but now just the past three days i have had a major flare up of deep muscle pains- I thought must be lymph because of how pinpointed they were. i have a lymph behind my ear - right side  -- this ear has been clogged adn will not open now for four months-- my lymph has gone up and down but never away for three months. Should I be concerned enough to get this checked for lymphoma at this point? I dont want ot miss something. I trust that God is walking me through this- I just want to use the brain He gave me too;) I have three small kids so any help would be appreciated. Thanks MelissaImage removed.

MelissaHIGH EBV 2/08,card/resp sx,numb hand,musc twitch/pains,neg for ms/lupus,scans hd 2 toe, abd/jnt/lymph pain, dizzy/fatigue, lymph swelling, lyme susp 9/08- igx-1 ++, cd57 52, CMV+, HHV6, MYCO-CAP11/08 NAC,Dxy,Zith MWF+sups

If NK cells are suppressed by Lyme, it would seem to make sense that LDN would be a good thing to take if you have Cpn or Lyme. Low Dose Naltraxone works to increase NK cells.

 

check out this link:

http://www.ldners.org/

Raven

PS: Mellissa, I am having a bout with a swollen lymph gland behind my ear. Try some hot towels wrung out in a salt water solution. Drink lots of water and sweat if you can (hot bath, heat lamp, sauna) There is also lymphatic drainage massage.

http://tinyurl.com/9rgxws

Feeling 98% well-going for 100. Very low test for Cpn. CAP since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NAC,BHRT, MethyB12 FIR Sauna. 1-18-11 begin new treatment plan with naturopath

raven

thanks

I am not sure if I know what ldn means- sorry. I tried one round of the lymph massage- not specifically for the spot. When I get out of a shower- it is almost totally back to flat but still there= does that happen to you? It is so hard for me to figure out what my pains are in my body right now- is it muscle? Is it lymph- is it toxin spot? is it joint- I can tell those but sometimes I  think they filter down through the muscle a a little. Thanks for the help:)

MelissaHIGH EBV 2/08,card/resp sx,numb hand,musc twitch/pains,neg for ms/lupus,scans hd 2 toe, abd/jnt/lymph pain, dizzy/fatigue, lymph swelling, lyme susp 9/08- igx-1 ++, cd57 52, CMV+, HHV6, MYCO-CAP11/08 NAC,Dxy,Zith MWF+sups

cocosmd - Hold your cursor over the little "i" next to unknown words. If the little "i" is there, a definition or at least an explanation of the abbreviation or acronym will be of help to you.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Hello all -I am back:)

Since I posted anxiously about my lymphs:) te one behind my ear has almost gone adn then come back with alot of friends all down my neck- most little - a few big:) but I have been reassured by several doctors- my DO and my Ent included - that this is normal fo rmy body to be reacting to things...

question:

All of those here who are dealing wiht cpn and lymes--- did you have a distinct tick bite incident??

MelissaHIGH EBV 2/08,card/resp sx,numb hand,musc twitch/pains,neg for ms/lupus,scans hd 2 toe, abd/jnt/lymph pain, dizzy/fatigue, lymph swelling, lyme susp 9/08- igx-1 ++, cd57 52, CMV+, HHV6, MYCO-CAP11/08 NAC,Dxy,Zith MWF+sups

Hi, Melissa - I don't know even know if I have Lyme (since I can't afford the Igenix test!) but I would not be at all surprised if I did mainly because I was bit by something around 30 years ago when I lived in the midwest, and they really didn't look for that type of rash back then in that part of the country.  Whatever it was that bit me, the rash was so huge my mom took me to the ER to have it checked out.

I don't remember if they gave me antibiotics for it - for whatever it was!  If not (and if it was a tick bite..) then it might explain at least some of the problems I've had.

Melissa I also sent you a PM if you could take a look?

Kelly

Diagnosed FMS Feb '07.  2x/day: 600 mg NAC, 100 mg Doxy, 500 mg Amoxicillin, 2000 iu Vit. D.  450 mg Valcyte.  250 mg Azi M/W/F.  500 mg 375 mg Flagyl pulses every 3-4 weeks.  Started CAP June '07. 

Thanks Kelly:)

I know I had tick bites when I was in girl scouts and camping as a child--- 25 yrs or more ago--- but it is odd that just now the past yr it would decide to pop up?? I did get the igenix test and there were enough "indeterminates" on it that my dr thinks it is a strong case for lymes. the one that was double positive was the crossover for epstein barr which I had through the roof as my DO put it. the quest and the labcorp test both showed the band that is the tail of the organism... which makes me think- could there be something else that would show as that??His big thing was the cd 57 of 52 I think it was. No wonder though with all the viral junk from ebv and cmv hitting me:) and we obviusly believe cpn jumped on the band wagon here too:)It is a mystery. I am actually going to go to another doc that my DO recommended for lyme and see what he thinks too I think.

Go body:) go fight win:) hehehe

 

Blessings and lets keep in touch

Melissa

 

melissa

MelissaHIGH EBV 2/08,card/resp sx,numb hand,musc twitch/pains,neg for ms/lupus,scans hd 2 toe, abd/jnt/lymph pain, dizzy/fatigue, lymph swelling, lyme susp 9/08- igx-1 ++, cd57 52, CMV+, HHV6, MYCO-CAP11/08 NAC,Dxy,Zith MWF+sups

Melissa,  I wondered the same thing myself: if it was Lyme to start with, why would it show up so much worse all these years later?  Possibly our immune system has been running well enough to keep the bug at bay for all these years, and then something else put the system over the top. 

Right before I developed one symptom after another after another (around Nov-Dec '06) my son and his friends had spent a weekend visiting another friend of theirs at college.  Right after they returned from the trip, their friend developed such a severe case of mono that he was unable to finish out the semester.  So recently I've began to wonder if it wasn't that EBV bug (which I did test positive for, along with CPn, CMV) - that finally maxed out my system(s).

But again, I may not have Lyme, so this speculating is probably/possibly all moot.  (But that rash was just - huge so it is hard for me to not wonder about that anyway, especially when I see various photos of the rash and think "hmmm that really does look sort of familiar!")

 

Kelly

Diagnosed FMS Feb '07.  2x/day: 600 mg NAC, 100 mg Doxy, 500 mg Amoxicillin, 2000 iu Vit. D.  450 mg Valcyte.  250 mg Azi M/W/F.  500 mg 375 mg Flagyl pulses every 3-4 weeks.  Started CAP June '07. 

CD 57+ Question-statement

 

I talked to a laboratory Doctor today and asked if when the cd 57 cells are low (mine were only once at 50 / after a metro pulse,before they were 96) allways lyme is suspected . I have done several lyme tests (LTT,Elisa, western Blot) all negative.

He said no not all. The cd 57 count goes down also with viral infections and other bacteria as well.  Anyone else who has no lyme has low cd 57 counts?

Male 38 years (Germany),CFIDS, IBS, Enterovirus, Cpn and Bartonella, Dientamoeba fragilis positive. Started Cap on 02/19/08, Currently taking Bactrim, Flagyl, soon adding Malarone and Clindamycin for suspected protozooa. 

Cesare,

That is what I am wondering about, too. Since my tests were not really shouting out lyme to me- and there was no point like Kelly was saying where I can remember a definite rash- though I think I heard that is only evident in like half of lyme cases or so- I am starting to think that the EBV and CMV and CPn were the ones that drove my cd57 down and not lyme at all. hmmmm- we will see I guess. I am going to another lyme expert here soon to get a second opinion.... that igenix test is too expensive not to ride it out for all it is worth:) and I cant do it again for sure. I have not had my level tested again since starting treatment a few months ago- my internalist wants me to wait a bit longer before testing blood work again,

 

Blessings as you recover...

Melissa

MelissaHIGH EBV 2/08,card/resp sx,numb hand,musc twitch/pains,neg for ms/lupus,scans hd 2 toe, abd/jnt/lymph pain, dizzy/fatigue, lymph swelling, lyme susp 9/08- igx-1 ++, cd57 52, CMV+, HHV6, MYCO-CAP11/08 NAC,Dxy,Zith MWF+sups

From my personal understanding, is that CD-57 is most specific for Borrellia, perhaps for other pathogens as well I do not know but very sensitive to level of activity for Borrelia in the body.   It was considered experimental by my insurance and denied for coverage of payment, (I had to self pay for it) so it is not used commonly in the general alopathic world of lab studies for other conditions.

I might suggest that you keep researching about the test from other sources yourself to see what you get from those other sources for information.

It is not a standard test in US, to my knowledge. 

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

My Bb(Lyme) test was activated because having been diagnosed by lab work for CPn.  I was started on Doxy high dose.  I then returned in 3 weeks feeling worse, so the MD at that time ordered a full infectious screening (including may viruses).  Very expensive but it revealed the Bb(Lyme) postitive results,   postive for reactivated infection by western blot.  Testing after starting abx is know to release dead fragments of Bb to the immune system and cause this pattern of postive results.  Some MD's call it an antibiotic challenge test and they test for Bb this way to enable the immune system to once again record the presence of Borrelia in the blood stream.  

Bb is very hard to test for, as CPn is as well, they become unseen by the immune system over time in many people.  So you could be treated for both of them for a long time with the money you spend trying to prove you have one or the other.   This is were the cost and response benefit sides with the emperical rationale for treatment.   

Dx is an art and some providers are better artists!  CD-57 is another screening tool to be used as part of the whole picture.   I am happy to be in treatment, I certainly was not getting better on my own without CAP.

Louise

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

I hear ya:) Whatever it is that is driving my cd 57 down-- I want to stop it:) I dont even have to know exactly what it was -that is ok with me as long as I build my body back up again. THese lymphs in my neck are really irksome to me- new ones popping out and some getting bigger etc- but my hubby keeps reminding me-- your immune system is working honey - it is a good thing:)       Go immune system

MelissaHIGH EBV 2/08,card/resp sx,numb hand,musc twitch/pains,neg for ms/lupus,scans hd 2 toe, abd/jnt/lymph pain, dizzy/fatigue, lymph swelling, lyme susp 9/08- igx-1 ++, cd57 52, CMV+, HHV6, MYCO-CAP11/08 NAC,Dxy,Zith MWF+sups

My first CD-57 is at 34

5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tini pulses,100 mg diflucan, 4.5 ldn; Wheldon protocol for MS April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.

I think mine was 66 - either before CAP, or shortly after starting.  I've just had more blood drawn today - hopefully he is re-checking the CD-57.  It seems like an awesome test, actually - maybe more reliable than the current Bb tests?

I too had the impression that it was specific for Bb - this would be good to know for sure.

Kelly

Diagnosed FMS Feb '07.  2x/day: 600 mg NAC, 100 mg Doxy, 500 mg Amoxicillin, 2000 iu Vit. D.  450 mg Valcyte.  250 mg Azi M/W/F.  500 mg 375 mg Flagyl pulses every 3-4 weeks.  Started CAP June '07. 

Minai, my 1st CD 57 test was done before CAP and it was 30. And I was BB (+). Then it was redone a month or 2 after starting CAP and when I was going thru major die-offs and CD57 was even lower then 20 (sorry can't remember exact #). I figured some T-cells hosts died together with Cpn. During the 1st year on CAP I did CD57 may be 5 times and it was never above 30. Always done in LabCorp.

Finally on a 13th month of CAP my CD57 is 38. I am going to re-test soon, it will be 16 months into treatment and I have improved greatly just within last 3 months. I can't wait to see results. My LLMD would like to see 180 before he releases me from treatment.

Nata.CAP Jan'08 to Dec'09 for arthritis. Doxy, Rif, Azith, Bactrim, Mino, Clarith, Flagyl, Amoxicillin. Re-started Dec.'10 for residual joint pain and painful heartbeat.Now: Mino 200 mg/day, Clarith  1000 mg/day, Flagyl 1000 mg/