Cathelicidins, Defensins and their Important Interactions with Leukotriene B4

 

Studies suggest that human cathelicidins (LL-37) and Leukotriene B4 may work in a positive feedback loop, meaning they may both stimulate each other for enhanced immunei<i< response:

And several studies suggest that Leukotriene B4, cathelicidins and defensins indeed play a very important role together in controlling infectionsi:

 

Many herbal supplementsi and prescription and non-prescription drugs are known to block production of Leukotriene B4 either by inhibiting all downstream leukotriene products of the 5-Lipoxygenase (5-LOX) pathway< or by blocking Leukotriene B4 (LTB4) directly.   Below is a list of several herbal supplement or prescription and non-prescription drugs that studies suggest may inhibit the 5-LOX pathway or block LTB4 directly:

 

Prescription and Non-Prescription Drugs:

 

Herbal Sources: