Vitamin D3 and its Effects on Matrix Metalloproteinase (MMP) ProductionVitamin D3 and its Effects on Matrix Metalloproteinase (MMP) Production
Matrix Metalloproteinases (MMPs) have a variety of destructive effects and have been found to be upregulated during Chlamydia pneumoniae infection. Vitamin D3, importantly has been shown to play an important role in regulating MMP production.The following studies show some of the effects that Vitamin D has been found to have over MMP production:
- Effect of 1, 25 dihydroxyvitamin D(3) on matrix metalloproteinases MMP-7, MMP-9 and the inhibitor TIMP-1 in pulmonary tuberculosis
- 1alpha,25-dihydroxyvitamin D inhibits matrix metalloproteinases induced by Mycobacterium tuberculosis infection
- Effect of 1,25-(OH)2D3 (a vitamin D analogue) on passively sensitized human airway smooth muscle cells.
- Heart extracellular matrix gene expression profile in the vitamin D receptor knockout mice
- Suppressive activity of vitamin D3 on matrix metalloproteinase production from cholesteatoma keratinocytes in vitro
- Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders?
Some links to past board discussions of MMPs in Cpn and Cpn-related diseasesi worth reading are: