Vitamin D Abstracts & Commentaries

Vitamin D Abstracts & Commentaries Jim K Mon, 2008-04-07 22:46

Vieth Slide Show on Vitamin D- see this one if nothing else

Vieth Slide Show on Vitamin D- see this one if nothing else

The charts alone make it crystal clear: lack of sun exposure, low D levels and a host of diseases result. Critical for all of us living in northern climates, but especially true for people of African descent with dark skin. It's apparent from his presentation that even 2000 units a day is not enough for the elderly, African Americans, and those of us with illness. 4000 units a day is more like it.http://wildhorse.insinc.com/directms13oct2005/ 

Jim K Fri, 2008-10-31 07:44

Another good article on Vit D3 & Autoimmune Disease

27 Apr 2018
Author
Red
Title

Another good article on Vit D3 & Autoimmune Disease

Body

Just ran across this fairly easy to read recent review article on Vit D3 and thought others might be interested:The Complex Role of Vitamin D in Autoimmune Diseases It's well worth a read...  

Comments

Thanks Red!  Can't wait to read it.  :o)

Big hugs!

TP 

 

--

May 2008. NACx1200mg, D3x2000mg, B12x1000mcg. Allergies, chronic inflamation, eczema, long-term steroid use, sinusitis/cysts, BL/TN, FM, CF, arthritis, rosacea.

Corinna | GFA. Wheldon Protocol: 4–8/08. Can't kill the yeast.

Red

You're welcome, TP!   How are you doing so far?

On Combined Antibiotic Protocol for Cpn in Rosacea 01/06 - 07/07, On Vit D3 + NAC since 07/07 and daily FIR Sauna since 08/07

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

I am having more bad days than good ones but I am convincing myself that this is somehow a good thing... I think my pancreas is unhappy because it hurts (??) My old Edmonton MD is considering taking this on with me...YIPPEE!!! Ahem, I'm mean I feel cautiously optimistic.  Image removed.

First thing he told me to do was up the Vitamin D to 6000/day.  That's a good sign!

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May 2008. NACx1200mg, D3x2000mg, B12x1000mcg. Allergies, chronic inflamation, eczema, long-term steroid use, sinusitis/cysts, BL/TN, FM, CF, arthritis, rosacea.

Corinna | GFA. Wheldon Protocol: 4–8/08. Can't kill the yeast.

Red

Too funny!   Glad to hear you're so cautiously optimistic!

Sorry to hear you're having more bad days than good, but this is really par for the course in the early days.  Still, remember attack the secondary porphyria with all options.  This is your big chance to pig out on those starchy carbs and glucose tabs with no guilt!

Keep us posted, and good luck with your Edmonton doc!  I like his advice on the Vit D3 btw.   In addition to its likely killing effects on Cpn, through the elevation of cathelicidins, it kills so many other pathogens that are likely involved as co-pathogens in many of our diseases/conditions.   I think it has been very instrumental in my own recovery.

But be careful about upping it too fast.   I can cause pretty heavy die-off and secondary porphyria symptoms itself...

 

On Combined Antibiotic Protocol for Cpn in Rosacea 01/06 - 07/07, On Vit D3 + NAC since 07/07 and daily FIR Sauna since 08/07

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

Thanks Red. I've jumped to 4000 which may explain the way I'm feeling. I'm up to 2400 mg NAC now too.

I really appreciate your guidance!

Big hugs!
TP

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May 2008. NACx2400mg, D3x4000mg, B12x1000mcg. Allergies, chronic inflamation, eczema, long-term steroid use, sinusitis/cysts, BL/TN, FM, CF, arthritis, rosacea.

Corinna | GFA. Wheldon Protocol: 4–8/08. Can't kill the yeast.

Red

That will definitely do it! Don't underestimate the power of the D...

As long as you don't have any medical reason not to, and I know this is counter to everything you've probably read up to this point about what you should do for good health, but definitely give glucose tabs a good try too. You can get them at any drugstore down here. I'm assuming it's the same up in your area:

http://www.drugstore.com/products/prod.asp?pid=37594&catid=10017

Take 2 or 3 and see if you don't feel a bit better in @ 20 minutes or so. If not, take another 2 or 3 to see if this works. If it does, you're likely suffering from secondary porphyria and should probably take glucose more regularly during the day to help minimize this problem. Others find the glucose based "Smarties" work too, and are cheaper. I seemed to notice more stomach irritation with them. Not sure why. Maybe it was the amount of citric acid. Anyway, glucose really helped earlier in treatment for me, and seems to really help others too...

I know you're probably worried about Candida, etc, but the cathelicidins elevated by Vit D3 have been shown to be pretty effective at killing Candida so do the glucose.  It may allow you to ramp up the Vit D3 more quickly...

Hope this helps. Keep us posted on your progress. I hope you feel better soon!

Big hugs back at you...

On Combined Antibiotic Protocol for Cpn in Rosacea 01/06 - 07/07, On Vit D3 + NAC since 07/07 and daily FIR Sauna since 08/07

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

Thanks Red!

I admit to forgetting about the glucose when I feel this way. My head's not connected to this all just yet. I will pick up the glucose tomorrow, the local pharm had set some aside for me a while back and I've let myself get sidetracked.

I'm not going to worry about the candida issues while taking this on, unless/until I have to. I will post on my blog with updates, sorry to derail this one...Image removed.

Best wishes,
TP

 

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May 2008. NACx2400mg, D3x4000mg, B12x1000mcg. Allergies, chronic inflamation, eczema, long-term steroid use, sinusitis/cysts, BL/TN, FM, CF, arthritis, rosacea.

Corinna | GFA. Wheldon Protocol: 4–8/08. Can't kill the yeast.

A superb review article, and a great find. Thanks Red! 

CAP for Cpn 11/04. Dx: 25yrs CFS & FMS. Currently: 300mg BID Roxithromycin, Bactrim DS 2x/day, Tini 1000mg/day pulses; Vit D2000 units, T4 & T3

Red

You're welcome, Jim.

TP, no worries about derailing this thread. You haven't...

The whole not thinking straight thing seems to be related to the secondary porphyria. The worse the secondary porphyria gets, the less reasoning you're able to muster.

If you have some sugar cookies on hand still, eat a couple tonight. They'll help you feel better. A caffeine-free sugary soda will even do.

Hang in there...

On Combined Antibiotic Protocol for Cpn in Rosacea 01/06 - 07/07, On Vit D3 + NAC since 07/07 and daily FIR Sauna since 08/07

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-
Red

Are Influenza Epidemics a Result of Low Sunlight and Vitamin D?

27 Apr 2018
Author
Jim K
Title

Are Influenza Epidemics a Result of Low Sunlight and Vitamin D?

Body

Gotta love this one.

Comments

This looks like a fantastic article. Not only from a vitamin D perspective, but also from an epidemiology/preventative-disease perspective. I'm probably abnormal, but I've been asking myself some of these questions for a long time. Finally some answers!

Thanks Jim.

garcia. 

 

Hunter: Don't think - experiment

Red

Great article, Jim.   Very intertesting read... Thanks!

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

Re-reading it, I'm even more impressed with the findings. The charts alone on cold/flu reduction from only 2000 units of D during winter months are worth the read. Want to protect yourself from the next pandemic? Forget Tamiflu, get your D levels up!

D2 vs D3 supplementation: article link

D2 vs D3 supplementation: article link

Most prescription D is D2 rather than the more effective D3. This article has an excellent review of the state of the science and why D3 is preferred for supplementation. http://www.ajcn.org/cgi/content/full/84/4/694 

Jim K Wed, 2008-10-29 18:22

Detailed Info on Vitamin D, especially in relation to MP

Detailed Info on Vitamin D, especially in relation to MP

A lot of people coming to the site here have questions about the Marshall Protocol and the Cpn CAP, where we recommend Vitamin D supplementation in contrast to MP. The most detailed analysis of the MP in relation to what is known in the scientific literature about Vitamin D occurs in this link:http://stuff.mit.edu/people/london/universe.htm 

Jim K Mon, 2008-04-07 23:04

Interesting Study on Importance of Vitamin D3 for Proper Thyroid Function

27 Apr 2018
Author
Red
Title

Interesting Study on Importance of Vitamin D3 for Proper Thyroid Function

Body

 Since so many on the site are dealing with thyroid issues, I thought I'd pass this along...First, here's a little news blurb on the study:Modern Medicine: Vitamin D Directly Affects Thyroid Function in Mice  Below is the full study article.  While the article focuses on Graves' hyperthyroidism, the discussion and conclusion sections list some interesting findings of recent research on Vitamin D3's importance for proper thyroid fun

Comments

Great find, Red. This might help make some sense over all the thyroid deficiency we see in CFIDS/ME from D deficiency compounded by infection, and certainly gives pause to pursuing a D deprivation model like the MP. Anyone here from the MP have resulting thyroid problems?

Red

Low Vitamin D Levels Linked to Chronic Pain in Women

27 Apr 2018
Author
Jim K
Title

Low Vitamin D Levels Linked to Chronic Pain in Women

Body

Posting this one as a whole, seems "fair use" for an informational web site, because it includes a useful discussion of the limitations of the methodology of the study not found in the abstract. Still, it behooves those of us with pain to consider Vitamin D levels as at least a variable that either modulates pain itself or contributes to other factors, like infection, that generate pain and inflammation. Low Vitamin D Levels Linked to Chronic Pain in Women Allison Gandey Medscape Medical News 2008.

Comments

Jim - And on the heels of your article

from the August 11, 2008, Archives of Internal Medicine (very reputable journal)

http://www.ncbi.nlm.nih.gov/pubmed/18695076

"Observational data suggests that low 25-hydroxyvitamin D levels (25[OH]D) are associated with diabetes mellitus, hypertension, and cancers. However, whether low serum 25(OH)D levels are associated with mortality in the general population is unknown. "

"the lowest quartile (25[OH]D levels <17.8 ng/mL) was associated with a 26% increased rate of all-cause mortality"

This is substantial by anyone's standards!

 

Daisy - Husband on CAP 5/07.  Husband died from Acute Myelogenous Leukemia Secondary to the Infusion of Novantrone.  Ie - the treatment with the conventional MS drugs killed him. Daisy on her own CAP 11/2012. 

More and more on Vitamin D

27 Apr 2018
Author
Jim K
Title

More and more on Vitamin D

Body

Following are some new Vitamin D abstracts by Holick. With 1,25-dihydroxyvitamin D involved in regulating more than 200 genes, you would think it might not be such a good idea to formulate treatment around Vitamin D starvation...Jim

Oliver Gillie's reports on Vitamin D's benefits available online

27 Apr 2018
Author
Red
Title

Oliver Gillie's reports on Vitamin D's benefits available online

Body

 Reports describing Vitamin D3's benefits by Oliver Gillie,  a freelance medical researcher and writer, are available online.

Comments

Red

By the way, although I believe the above reports make an important case for the involvement of low levels of Vitamin D3 in the pathogenesis of Multiple Sclerosis and other "autoimmune" diseases, IMHO, the expert researchers on Vitamin D3 may also be missing much of the reason for this, namely the importance of Vitamin D3 in controlling or preventing the infections that have been linked with these diseases.  

The article above mentions the antimicrobial peptides (cathelicidins) that so require Vit D3 for their production, but it really only mentions these cathelicidins in reference to tuberculosis.   The article also mentions Vit D3's importance for normal cellular apoptosis, but again it only mentions this in reference to cancer.  

IMHO, these researchers may be missing the importance of these two (and probably other) effects of Vit D3 in in controlling infections that may cause disease.   As we are aware, Vit D3 may influence levels of Chlamydia pneumoniae infection through its effects on the ability of the Chlamydia pneumoniae to prevent apotosis (and replicate protected inside a cell) for instance.   And cathelicidins may be important in keeping the henchmen Herpes viruses dormant, where they belong.

These researchers also don't seem to ever mention the relatively recently discovered importance of Leukotriene B4 for the induction of cathelicidins upon immune system detection of pathogens. What effects did the introduction of modern medicines that block the production of Leukotriene B4 so well and therefore significantly reduce the induction of already reduced levels of cathelicidins (due to low levels of Vit D3) upon immune system detection of pathogens have on disease rates?    I wonder...

Although I have no medical background, I personally believe the pathogenesis of many of the "autoimmune" diseases that these researchers point to heavy involvement of low levels of Vit D3 in their pathogenesis may actually be far more complex than these researchers realize.    Still, bless these researchers for the efforts!

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

Red- thanks for your quick summary of the Vitamin D web here in terms of Cpn. Because of your interest in Leucotrines related to rosacea, you probably have a better grasp on this than any of us of these interactions.

Red

Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need?

Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need?

Adv Exp Med Biol. 2008;624:1-15.Links   Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need?   Holick MF.    Department of Medicine, Section of Endocrinology, Nutrition and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, 715 Albany Street, M-1 013, Boston, MA 02118, USA. mfholick@bu.edu    Vtamin D is the sunshine vitamin for good reason. During exposure to sunlight, the utraviolet B photons enter the skin and photolyze 7-dehydrocholesterol to previtamin D3 which in turn is isomerized by the body's temperature to vitamin D3. Most humans have depended on sun for their vitamin D requirement. Skin pigment, sunscreen use, aging, time of day, season and latitude dramatically affect previtamin D3 synthesis. Vitamin D deficiency was thought to have been conquered, but it is now recognized that more than 50% of the world's population is at risk for vitamin D deficiency. This deficiency is in part due to the inadequate fortification of foods with vitamin D and the misconception that a healthy diet contains an adequate amount of vitamin D. Vitamin D deficiency causes growth retardation and rickets in children and will precipitate and exacerbate osteopenia, osteoporosis and increase risk of fracture in adults. The vitamin D deficiency has been associated pandemic with other serious consequences including increased risk of common cancers, autoimmune diseases, infectious diseases and cardiovascular disease. There needs to be a renewed appreciation of the beneficial effect of moderate sunlight for providing all humans with their vitamin D requirement for health.

Jim K Mon, 2008-04-07 22:52

The tolerability and biochemical effects of high-dose bolus vitamin D2 and D3 supplementation in patients with vitamin D insuffi

27 Apr 2018
Author
Daisy
Title

The tolerability and biochemical effects of high-dose bolus vitamin D2 and D3 supplementation in patients with vitamin D insuffi

Body

The tolerability and biochemical effects of high-dose bolus vitamin D2 and D3 supplementation in patients with vitamin D insufficiency.Leventis P, Kiely PD.Department of Rheumatology, St George's Healthcare NHS Trust, London, UK.Objectives: To investigate the practicality and tolerability of high-dose intramuscular (i.m.) vitamin D2 or oral vitamin D3 replacement in vitamin D-insufficient patients, and to evaluate the biochemical efficacy of each formulation.

Comments

Daisy,  Thanks for this---it addresses a concern I've had as to whether or not taking D3 would exacerbate my already elevated calcium level.

Joyce~caregiver-advocate in Dallas for Steve J (SPMS).  CAP since August 06, Cpn, Mpn, B. burgdorferi, systemic candidiasis, EBV, CMV & other herpes family viral infections, elevated heavy metals, gluten+casein sensitivity. 

Red

Good one, Daisy.  Thanks!

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

Vitamin D Council and brief quote on Vit D in sarcoidosis

Vitamin D Council and brief quote on Vit D in sarcoidosis

The Vitamin D Council is an excellent source of information on Vitamin D, health and science (thanks Reenie:).http://vitamindcouncil.orgTheir research page is a useful listing of all the conditions in which insufficient Vitamin D has been linked to, including cancer, MS and autism. http://vitamindcouncil.org/research.shtml Of interest to sarcoidosis patients looking to cautiously increase Vitamin D as part of a CAP for Cpn:

Hypersensitivity, Not Toxicity Vitamin Di hypersensitivity syndromes are often mistaken for vitamin D toxicity. The most common is primary hyperparathyroidism. Other syndromes occur when abnormal tissue subverts the kidney's normal regulation of endocrine calcitriol production. Aberrant tissues, usually granulomatous, convert 25(OH)D into calcitriol causing high blood calcium. The most common such condition is sarcoidosis, oat cell carcinoma of the lung and non‑Hodgkin's lymphoma but other illness can cause the syndrome and they can occur while the patient's 25(OH)D levels are normal or even low. For that reason, while rare, it is advisable to seek a knowledgeable physician's care when repleting your vitamin D system, especially if you are older, have sarcoidosis, cancer or other granulomatous diseasesi. In such high‑risk patients, periodic monitoring of 25(OH)D levels and serum calcium will alert the physician to the need to do more tests, such as calcitriol or PTH, and take further action.However, it seems clear that restoring physiological serum levels of 25(OH)D will help many more patients that it will hurt. In fact, living in America today while worrying about vitamin D toxicity is like dying of thirst in the desert while worrying about drowning.http://www.vitamindcouncil.org/vitaminDToxicity.shtml 
Jim K Thu, 2008-07-10 22:44

Vitamin D Inhibits Entry of Intracellular Pathogen

Vitamin D Inhibits Entry of Intracellular Pathogen

Although this is with a different intracellular pathogen than Cpn, it suggests one of the possible protective mechanisms that Vitamin D gives against intracellular pathogens. Like Cpn,  Mycobacterium tuberculosis infects the immune cells (macrophages) themselves, and this study describes the inhibition of cell invasion by Vitamin D. J Microbiol Immunol Infect. 2008 Feb;41(1):17-25. Synergistic action of vitamin D and retinoic acid restricts invasion of macrophages by pathogenic mycobacteria. Anand PK, Kaul D, Sharma M. Molecular Biology Unit, Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. BACKGROUND AND PURPOSE: Phagosomal maturation arrest is known to play a central role in the survival of pathogenic mycobacteria within macrophages. The maturation arrest of mycobacterial phagosome results from the retention of tryptophan-aspartate-containing coat protein (TACO) on this organelle, enabling successful replication of the pathogen. We have shown earlier that vitamin D(3) and retinoic acid (RA) down-regulate TACO gene transcription in a dose-dependent manner. METHODS: In this study, we analyzed the promoter region of TACO gene using bioinformatics tools and observed that the vitamin D receptor (VDR)/retinoid-X-receptor (RXR) response sequence was highly functional. We also evaluated the effect of treatment with vitamin D(3)/RA on Mycobacterium tuberculosis entry and survival in cultured human macrophages. RESULTS: TACO gene down-regulation observed with vitamin D(3)/RA treatment occurred through modulation of this gene via the VDR/RXR response sequence present in the promoter region of TACO gene. Treatment of macrophages with vitamin D(3)/RA allows maturation of mycobacterial phagosome, leading to degradation of the pathogen. CONCLUSIONS: Our results elucidate the mechanism of TACO gene down-regulation observed with vitamin D(3)/RA. Furthermore, the results revealed that vitamin D(3)/RA treatment inhibits mycobacterial entry as well as survival within macrophages, possibly through rescue of phagosome maturation arrest. The developing knowledge in this area suggests that vitamin D(3)/RA may be of importance in the treatment of intracellular infection, particularly tuberculosis.

Jim K Mon, 2008-09-08 15:48

Vitamin D Pathways - Importance of IL-15

27 Apr 2018
Author
Red
Title

Vitamin D Pathways - Importance of IL-15

Body

Here's another interesting area to keep an eye on, namely the apparent importance of IL-15 for bioconversion of 5-hydroxyvitamin D3 (25D3) into bioactive 1,25D3 and the downstream induction of cathelicidins:

Red

Vitamin D Status: Measurement, Interpretation, and Clinical Application.

Vitamin D Status: Measurement, Interpretation, and Clinical Application.

 Ann Epidemiol. 2008 Mar 8 [Epub ahead of print]Click here to read Links   Vitamin D Status: Measurement, Interpretation, and Clinical Application.   Holick MF.    From the Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA.    Vitamin D, the sunshine vitamin, is now recognized not only for its importance in promoting bone health in children and adults but also for other health benefits, including reducing the risk of chronic diseases such as autoimmune diseases, common cancer, and cardiovascular disease. Vitamin D made in the skin or ingested in the diet is biologically inert and requires 2 successive hydroxylations first in the liver on carbon 25 to form 25-hydroxyvitamin D [25(OH)D], and then in the kidney for a hydroxylation on carbon 1 to form the biologically active form of vitamin D, 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. With the identification of 25(OH)D and 1,25(OH)(2)D, methods were developed to measure these metabolites in the circulation. Serum 25(OH)D is the barometer for vitamin D status. Serum 1,25(OH)(2)D provides no information about vitamin D status and is often normal or even increased as the result of secondary hyperparathyroidism associated with vitamin D deficiency. Most experts agree that 25(OH)D of < 20 ng/mL is considered to be vitamin D deficiency, whereas a 25(OH)D of 21-29 ng/mL is considered to be insufficient. The goal should be to maintain both children and adults at a level > 30 ng/mL to take full advantage of all the health benefits that vitamin D provides.

Jim K Mon, 2008-04-07 22:48

Vitamin D and skin physiology: a D-lightful story.

Vitamin D and skin physiology: a D-lightful story.

J Bone Miner Res. 2007 Dec;22 Suppl 2:V28-33.Click here to read Links   Vitamin D and skin physiology: a D-lightful story.   Holick MF, Chen TC, Lu Z, Sauter E.    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, USA.    Throughout evolution, exposure to sunlight and the photosynthesis of vitamin D(3) in the skin has been critically important for the evolution of land vertebrates. During exposure to sunlight, the solar UVB photons with energies 290-315 nm are absorbed by 7-dehydrocholesterol in the skin and converted to previtamin D(3). Previtamin D(3) undergoes a rapid transformation within the plasma membrane to vitamin D(3). Excessive exposure to sunlight will not result in vitamin D intoxication because both previtamin D(3) and vitamin D(3) are photolyzed to several noncalcemic photoproducts. During the winter at latitudes above approximately 35 degrees , there is minimal, if any, previtamin D(3) production in the skin. Altitude also has a significant effect on vitamin D(3) production. At 27 degrees N in November, very little ( approximately 0.5%) previtamin D(3) synthesis was detected in Agra (169 m) and Katmandu (1400 m). There was an approximately 2- and 4-fold increase in previtamin D(3) production at approximately 3400 m and at Everest base camp (5300 m), respectively. Increased skin pigmentation, application of a sunscreen, aging, and clothing have a dramatic effect on previtamin D(3) production in the skin. It is estimated that exposure in a bathing suit to 1 minimal erythemal dose (MED) is equivalent to ingesting between 10,000 and 25,000 IU of vitamin D(2). The importance of sunlight for providing most humans with their vitamin D requirement is well documented by the seasonal variation in circulating levels of 25-hydroxyvitamin D [25(OH)D]. Vitamin D deficiency [i.e., 25(OH)D < 20 ng/ml] is common in both children and adults worldwide. Exposure to lamps that produce UVB radiation is an excellent source for producing vitamin D(3) in the skin and is especially efficacious in patients with fat malabsorption syndromes. The major cause of vitamin D deficiency globally is an underappreciation of sunlight's role in providing humans with their vitamin D(3) requirement. Very few foods naturally contain vitamin D, and those that do have a very variable vitamin D content. Recently it was observed that wild caught salmon had between 75% and 90% more vitamin D(3) compared with farmed salmon. The associations regarding increased risk of common deadly cancers, autoimmune diseases, infectious diseases, and cardiovascular disease with living at higher latitudes and being prone to vitamin D deficiency should alert all health care professionals about the importance of vitamin D for overall health and well being.

Jim K Mon, 2008-04-07 22:50

Vitamin D and the immune system: role in protection against bacterial infection.

27 Apr 2018
Author
Jim K
Title

Vitamin D and the immune system: role in protection against bacterial infection.

Body
Curr Opin Nephrol Hypertens. 2008 Jul;17(4):348-52.

Wonderful Paper on Vitamin D, with focus on Vitamin D and the Nervous System

27 Apr 2018
Author
Red
Title

Wonderful Paper on Vitamin D, with focus on Vitamin D and the Nervous System

Body

 This is a wonderful Academic Dissertation by Anna Minasyan, from Tampere University Medical School:Vitamin D and the Nervous System It contains an amazingly complete and fairly easy to read (if you can skim through all the citations) review of the known actions of Vitamin D in the body, including very good explanations of the known pathways.   Here are a few sections that I believe are particularly important:

Red