Multiple Sclerosis Research

Multiple Sclerosis Research

MS is covered in this page. Please read more from the other research pages also as it is the whole picture that makes it compelling not just what is here....

A review of PCR in CPn infection by David WheldonThere are many studies on MS using the PCR to look for CPn. this review by David Wheldon is insightful

Chlamydia Pneumoniae infection in Neuronal cells lines

CPn respiratory infection associated with relapse in MS

Annotation by Marie with links on nitric oxide CPn and MS

Nitric Oxide and CPn: Multiple sclerosis link?

CPn infection induces transmigration of monocytes through human brain epithelial cells This work was undertaken to see if CPn might transmigrate because there is some work associating CPn with AD. Once you see that it can migrate across the BBB and that it can infet microglia and brain cells, is it such a leap to imagine it could cause MS?

Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis The newest published research on CPn in MS released October 1 2005. This work used several methods for detection of CPn in these MS patients, proving this work to be very thorough and extremely convincing. Many others have "tried" to find CPn using one method such as PCR, but his work also reaffirmed the assertion that CPn was present with other approaches as well.

-Pilot study to examine the effect of antibiotics on MRI outcomes in RRMS This is the most recent research to read if you are interested in MS and CPn. This study was small but it highlights interesting points about the reaction of the MS brain to antibiotic treatment.

The clinical response to minocycline in multiple sclerosis is accompanied by beneficial immune changes: a pilot study. This study was looking at minocin as an imunomodulatory agent but the positve responses in terms of gad enhancing lesions and relapses makes a person consider that there is likely more than one reason to do CAPs.

-Assoc. of Chlamydia pneumonie with nervous sytem disease This paper is a must read if you have MS.

Chlamydia pneumoniae infection of microglial cells Very important paper. Please read.

CSF molecular demonstration of CPn DNA is associated with cinical and brain magnetic resonance in RRMS This paper from 2004 shows that several neurolgoical diseases are associated with evidence of CPn in the brain, but also indicates that active disease of MS has a higher association. Importantly taken with Balin's work on AD we are beginning to see a neurological pathogen that possibly causes several kinds of brain pathologies. Since we know other germs like staph has the same kind of differing presentations, is that really so odd?

Epidemiologic Evidence for MS as an infection- J F Kurtzke Classic important paper. Kurtzke is clear that an infectious agent is to blame for MS. This in depth report includes an immene amount of data on the Faroese.

mrhodes40 Sat, 2006-06-03 16:07

Bacterial Genomics Reveals MS Trigger

27 Apr 2018
Author
jeanneroz
Title

Bacterial Genomics Reveals MS Trigger

Body

Infection with a common bacteria could be the switch that turns on the autoimmune response in multiple sclerosis (MS) according to the findings of Wayne State University PhD graduate, Derek Lenz, now of the Scripps Research Institute in La Jolla, Calif. He described the work he carried out as part of Robert Swanborg’s team at Wayne State University School of Medicine. He said studies in rats show that an antigen found in the bacteria Chlamydia pneumoniae mimics part of a myelin protein in the animal’s central nervous system.

Comments

You GO, Derek Lenz! Thanks for finding this Jeanneroz. I am SO going to enjoy re-educating that young neuro I fired three years ago!

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Well of course we knew this here, but isn't it great to have ones beliefs validated, yet again.

Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse.

Jeanneroz, could you cut and past the full link out in view then add a space to it and it may work for me.  I cannot access the article throught the link mechanism that you provided.  Thanks for sharing.  Louise

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

A doctor who does his homework, good deal. More doctors should be a little more curious about their profession and read up on stuff like this. We the patient shouldnt have to be the initiater.

Fibro, CFS,  Myco, CPN, Stratton protocol, Zithro 500mg M/W/F/S, Doxy 100mg 2x day, NAC 1200mg 2x day, Flagyl and INH 2 week pulses 400 mg 3x day, Rifampin, 300mg 2x day,  Still cant shake it but improving.

Yet, we are the initiators and have been for a very long time.Thank goodness, we are not alone and have the brilliant questioning that makes this site so unique.

Educating neuros is a good idea if one can bear hearing the negativity aimed at all of us.

Everyone here, man or woman -  YOU GO!!!!!!

Happy 2009. I am with all of you, in spirit, hopes and desires.

Loulou

diagnosed MS Jan.2000 ,  chronic neurological lyme disease Nov.2002.doxy 100 mg. 1BID. roxy.150 mg.? BID,adding rifampin soon, pulsed tini. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDN),NAC, nystatin, major wheldon supplemrnts daily,

Season's greetings everyone, but has anyone noticed that this link from Wayne State University is six years old?.............Sarah

An Itinerary in Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

I didn't really think it mattered... but don't you find it interesting that 6 YEARS AGO they made the possible connection??

 

JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

Wayne State has been doing work of this sort for many years.Dr. Lida Mattman , recently deceased, virologist, etc. penned the medical book Stealth Pathogens in the 80s out of Wayne State. Originally  professor emeritus from Yale - a brilliant woman and ahead of her time.

So we all should pay attention.

Loulou

diagnosed MS Jan.2000 ,  chronic neurological lyme disease Nov.2002.doxy 100 mg. 1BID. roxy.150 mg.? BID,adding rifampin soon, pulsed tini. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDN),NAC, nystatin, major wheldon supplemrnts daily,

Actually, as I read it, cpn is here considered a trigger for the AUTO-IMMUNE disease of ms. That's a possibility that we have not ruled out but, as I understand it, we do not generally consider MS an auto-immune disease. Am I wrong?

PPMS-misdiagnosed 2001-diagnosed 2006. Probably caught cpn in birth canal but it didn't pass BBB until my 40s. Minocycline 7 mos.- resulting bronchitis 5 months.Go to private m.d. out-of-plan. Wheldon CAP 3/2/07 Stopped 12/12; resumed 12/13

Autoimmune or not?????????????That is the pervasive question..................Some neuros say yes autoimmune, others say no...

Dr. Wheldons protocol gives us some hope..The rest are merely names - I keep going.What else is there??

LOULOU

diagnosed MS Jan.2000 ,  chronic neurological lyme disease Nov.2002.doxy 100 mg. 1BID. roxy.150 mg.? BID,adding rifampin soon, pulsed tini. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDN),NAC, nystatin, major wheldon supplemrnts daily,

Sorry, everyone, but I didn't think anyone had noticed the date.  This is old news and DW was corresponding with Hudson years ago.  I thought it was sad that things had changed so little since then................Sarah

An Itinerary in Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

It is definitely sad. Thank you DW .

Things in medicine are profoundly slow.Sarah, I'm sure you know more about the inner circles of the med. system than most?

This, so to speak, hierarchy makes us so aware that pharmaceutical companies appear to unfortunately govern medicine and  the "practice" of it.eg. no cause, no cure, bacterial, viral, and the list goes on and on.....

Forget the politics as much as possible. Do what you can . Exercise, go outside (weather permitting), stay on CPN.....................

Loulou

I'm starting to sound political. Must be the times we're living in.

Happy 2009

diagnosed MS Jan.2000 ,  chronic neurological lyme disease Nov.2002.doxy 100 mg. 1BID. roxy.150 mg.? BID,adding rifampin soon, pulsed tini. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDN),NAC, nystatin, major wheldon supplemrnts daily,

loulou - "Stay on cpn"????????   You are hereby banished from the punchbowl. Cpn=bad. ABX=good. Image removed.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

It is possible it is autoimmune and directly attacks tissue, HSP 60 maybe, and very likely genetic and environmental.  That is maybe why it has taken so long to tie everything together, many variables.

 

The body is very complex, it is very hard to experiment with people much less track them.  Medicine is very political.  All things to slow finding the cure.  Many very fine doctors now are on the germs trail, it will get a lot harder for it to do damage as before.

Cpn, Mycoplasma, Chronic EBV, M.S.(MRI, Spinal Tap-greater than 5 oligoclonal bands and VEP), PANDAS(OCD). Wheldon CAP (started 12/08), Azithromycin/Clarithromycin(12/09), Lithium, Lamictal, NAC(2.4g/day), D3(15,000IU/day)

Whoops! Confused for a change.....................not cpn    YES cap, YES antis.

Thanks Mac for pointing that out- I missed it.

Loulou

diagnosed MS Jan.2000 ,  chronic neurological lyme disease Nov.2002.doxy 100 mg. 1BID. roxy.150 mg.? BID,adding rifampin soon, pulsed tini. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDN),NAC, nystatin, major wheldon supplemrnts daily,

If Dr. Lida Mattman wrote the medical book "Stealth Pathogens" in the 80's, and was a Nobel Prize candidate because of it, then why in the world are so many having so much trouble finding doctors who will go along with this protocol, and why is there such a battle within the medical community?  I honestly and truly don't understand.

Kelly

Diagnosed FMS Feb '07.  2x/day: 600 mg NAC, 100 mg Doxy, 500 mg Amoxicillin, 2000 iu Vit. D.  450 mg Valcyte.  250 mg Azi M/W/F.  500 mg 375 mg Flagyl pulses every 3-4 weeks.  Started CAP June '07. 

I  wish I knew a solid unbiased answer to your valid questions.

Get involved with ILADS. mORE INFO THat ,as me, will make you more aware, however, add to your confusion. Hoping this baffling info will stop, once and for all BUT I bet it doesn't!!

Happy 2009

Loulou

ps Let it suffice to inform you that Dr. Mattman was hidden, literally, for her beliefs, almost thrown in jail, etc.etc. I stayed with her close to the end of her proud,informative life. I learned a lot from her.

diagnosed MS Jan.2000 ,  chronic neurological lyme disease Nov.2002.doxy 100 mg. 1BID. roxy.150 mg.? BID,adding rifampin soon, pulsed tini. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDN),NAC, nystatin, major wheldon supplemrnts daily,

Wow, LouLou - where was Erin Brockovich during all of this?!  Dr. Mattman's story sounds fascinating - it would be great to see a book written about her life!  She really was the pioneer, wasn't she?  So sad that she was also a pioneer for those persecuted for daring to have evidence that contradicts those who hold the power.

Kelly

Diagnosed FMS Feb '07.  2x/day: 600 mg NAC, 100 mg Doxy, 500 mg Amoxicillin, 2000 iu Vit. D.  450 mg Valcyte.  250 mg Azi M/W/F.  500 mg 375 mg Flagyl pulses every 3-4 weeks.  Started CAP June '07. 

Chlamydia pneumoniae-specific intrathecal oligoclonal antibody response predominantly detected in subset of multiple sclerosis

Chlamydia pneumoniae-specific intrathecal oligoclonal antibody response predominantly detected in subset of multiple sclerosis

J Neurovirol. 2010 Jan 6. [Epub ahead of print]Chlamydia pneumoniae-specific intrathecal oligoclonal antibody response is predominantly detected in a subset of multiple sclerosis patients with progressive forms.Fainardi E, Castellazzi M, Tamborino C, Seraceni S, Tola MR, Granieri E, Contini C.Neuroradiology Unit, Department of Neurosciences and Rehabilitation, Azienda Ospedaliera-Universitaria, Arcispedale S. Anna, Ferrara, Italy.The purpose of this study was to verify the actual involvement of Chlamydia pneumoniae in multiple sclerosis (MS) by the evaluation of its specific intrathecal humoral immune response in MS. We measured by enzyme-linked immunosorbent assay (ELISA) technique cerebrospinal fluid (CSF) and serum levels of anti-C. pneumoniae immunoglobulin G (IgG) in 27 relapsing-remitting (RR), 9 secondary progressive (SP), and 5 primary progressive (PP) MS patients, grouped according to clinical and magnetic resonance imaging (MRI) evidence of disease activity. Twenty-one patients with other inflammatory neurological disorders (OIND) and 21 with noninflammatory neurological disorders (NIND) were used as controls. Quantitative intrathecal synthesis of anti-C. pneumoniae IgG was determined by antibody-specific index (ASI), whereas the presence of C. pneumoniae-specific CSF oligoclonal IgG bands was assessed by antigen-specific immunoblotting. ASI values indicative of C. pneumoniae-specific intrathecal IgG synthesis were present in a small proportion of MS (29.3%), OIND (33.3%), and NIND (4.8%) patients and were significantly more frequent (P < .05) in total MS and in OIND than in NIND and in SP (P < .01) and PP MS (P < .05) than in RR MS. C. pneumoniae-specific CSF-restricted OCB were detected only in three SP, one PP, and one RR MS patients. These findings suggest that an intrathecal production of anti-C. pneumoniae IgG is part of humoral polyreactivity driven by MS chronic brain inflammation. However, an intrathecal release of C. pneumoniae-specific oligoclonal IgG can occur in a subset of patients with MS progressive forms in whom a C. pneumoniae-persistent brain infection may play a pathogenetic role. http://www.ncbi.nlm.nih.gov/pubmed/20053141?itool=Email.EmailReport.Pub…

Jim K Sat, 2010-01-09 14:39

Cpn DNA and mRNA in PMBC's and CSF of patients with multiple sclerosis.

27 Apr 2018
Author
Jim K
Title

Cpn DNA and mRNA in PMBC's and CSF of patients with multiple sclerosis.

Body
Neurosci Res. 2008 Sep;62(1):58-61. Epub 2008 May 20.

Chlamydophila pneumoniae DNA and mRNA transcript levels in peripheral blood mononuclear cells and cerebrospinal fluid of patients with multiple sclerosis.

Molecular detection of Parachlamydia-like organisms in cerebrospinal fluid of patients with multiple sclerosis.

27 Apr 2018
Author
Jim K
Title

Molecular detection of Parachlamydia-like organisms in cerebrospinal fluid of patients with multiple sclerosis.

Body
Mult Scler. 2008 May;14(4):564-6

Molecular detection of Parachlamydia-like organisms in cerebrospinal fluid of patients with multiple sclerosis.

Comments

THANKS JimK

we know that!!  Glad some research is being done, that is excellent.

peace

r

 

CFIDS/ME, FMS, MCS, IBS, EBV, CMV, Cpn, H1, chronic insomnia, Chronic Lyme, HME, Babesia, Natural HRT-menopause, NAC 2.4 gm,Full CAP 6-2-07, all supplements+Iodorol, Inositol-depression, ultra Chitosan, L lysine Pulse#27 04-19-10 1gm Flagyl/day-5 days<