B12 Methylcobalamin Dosage And CPn Antibody Attachment?

Saying as CPn continually creates antibodies that attach to B12 meaning your body can't utilise all the B12 that is stored, why after 3 months should the 4000mcg dosage of B12 be reduced to taking once per day?  Will it harm continuing to take 3 times daily, even though it seems to have made no difference to Paula's fatigue?



Mark- the idea is to flood the system with B12 initially so as to fill up the antibodies and then have excess for the organs that utilize B12. Certain organs like the liver will scarf up all the available free B12 until they have a sufficiency and enough free B12 (unbound to antibodies) is still in the blood stream to be available to other systems.

That said, there is more known about general problems in methylation, especially with folks who have CFS/ME, and simple B-12 supplementation may not do the trick. I'm not familiar enough with it to explain, but someone will be along to describe the methylation protocol which uses a couple of other supplements in addition to B-12. There are a number of folks using this actively as part of their protocol. You could do a search here on methylation and see what's about.

By the way, I used B-12 injections for about the first 2 years of the protocol. Initially it wasn't clear that it was helping, then I noticed more resiliency in things like traveling. It wasn't really ever energizing for me, but I seemed to tolerate some things better. The injections were clearly more effective for me than oral supplement, even the methylcobolamin form.


CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Thanks Jim.  I'll look into methylation.

A year or so ago, before we had heard of the CAP, I asked our NHS GP to look into trying B12 injections.  She said that they used to give them to people who had general fatigue, but after talking to the partners at the GP practice, it was decided that Paula couldn't be given the injections because they were not licensed to be given to people with CFS!

I despair with the NHS and have given up on them where CFS is concerned.

Image removed.

UK Carer of bedridden Severe CFS Feb06. Tick bites Summer04.  CPN dx.Apr07. Borrelia dx Sept08. Samento 15 drps daily July07.  200mg Doxy Jan08.  300mg Roxy Apr08 Stopped abx Nov/Dec08. Building up on Supps again.

Mark the play on words game.  General fatigue is not part of being chronically fatigued?  How about if you call again and say that she had unrelenting fatigue and skip the chronic part.  There are those people that qualify by blood work, did they even test her? 

Please share what you find regarding methylation in detail as able.  If you do please start a new topic, it could be a very interesting read.


Mark- the keywords are  Yasko Methylation Protocol and the modified version by Van Konynenburg. The modified version is simpler and rather than starting with (very expensive) pretesting starts with a shotgun approach and modifies based on responses.


CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Mark here is something that I found with my cut and past to google from Jim's comment.

Seems that this person is in the UK, on quick scan I see infection (in general) mentioned.

this is a large pdf posting.  http://www.drmyhill.co.uk/cfs_book.pdf are you aware of her work?


  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support