Submitted by mrhodes40 on Mon, 2005-09-05 18:37

Microbes Infect. 2003 Nov;5(13):1249-53. Related Articles, Links

Association of Chlamydia pneumoniae with central nervous system disease

Stratton CW, Sriram S
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
Chlamydia pneumoniae is a common respiratory pathogen that is now being incriminated in a number of
chronic diseases. The ability of C. pneumoniae to infect and persist in macrophages makes it a likely
candidate to disseminate in a number of different tissues, including those of the central nervous system.
This review addresses the potential and the underlying mechanisms by which C. pneumoniae infections can
play a role in such diverse neurological diseases as multiple sclerosis and Alzheimer's disease.

Publication Types:
Review, Tutorial
PMID: 14623021 [PubMed - indexed for MEDLINE]

If you would like topurchase the whole citation from Elsevier you may do so
Here are some highlights from the citation which are important to note ( this is of course
referenced): chlamydia pneumoniae (CPn) can infect peripheral mononeuclear cells. From there they
stimulate chemokines and cytokines inducing inflammation. They also alter the BBB by altering the brain
microvascular endothelial cells. In fact it has been shown that CPn induces crossing of the BBB by
mononeuclear cells. These features suggest it may be a cofactor or causitive agent in CNS disease. The
focus of this work is to explore whether or not it is plausible for CPn to be a cofactor or cause of MS
based on animal studies. It is shown that EAE is worsened by the presence of CPn and that it must be the
active/infective form to cause this problem, that CPn causes autoimmunity in mice, and that the disease
was attenuated by giving the mice antibiotics. This well referenced paper makes a strong argument for
the possibility.