antibiotic or antifungal?

I was talking to a pharmacist friend of mine who I've shared the Wheldon protocol with and how it works.  I was explaining to her that a pulse is when you're on a bacterioside, either metronidazole or tinidazole for a period of up to five days, then off of it for the following three weeks, then repeat that process.  I told her about being on two bacteriostatic drugs constantly at other times. 

She commented on metronidazole being classified as an antifungal rather than an antibiotic, which surprised me, but that's how it's classified here by pharmacists.  I suppose it's possible that she was remembering incorrectly but I trust her judgement and professionalism.  This raised the question in my mind as to whether or not it was an antifungal and whether or not it would be helpful in combatting candida and other fungi one might contract while following the protocol?  Of course, since it's only pulsed, I'm thinking it will only help for the five days on a pulse but would be interested in opinions.

It does not make sense to me that metronidazole is classified as antifungal, since in many studies it appears to increase fungal load not decrease it. I'll have to do some digging to find whether I'm recalling the studies correctly.

It is classified in the US as antibacterial and antiprotozoal. It is antibacterial especially against anaerobic bacteria.  

Combined Antibiotic Protocol for Chlamydia pneumonia in Chronic Fatigue Syndrome & Fibromyalgia- Currently: 150mg INH, Doxycycline/Zithromycin, Tinidazole pulses. Northern Ohio, USA

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Jim, that's contrary to what my pharmacist friend was telling me.  It's not classified as an antibiotic but as an antifungal, or so she was telling me.  She agreed that it has antibiotic activity against some bacteria and may be a bacterioside, but she insisted that it was classified as an antifungal. 

all my best

John

RRMS/EDSS 4.5 on Wheldon Protocol (doxycycline, azithromycin, metronidazole) since 04/12/2006

best, John

RRMS/EDSS was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
nac 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazole 3x400mg/day then 3x500mg/day

My Dr. also referred to it as an antifungal and this was a big surprise to me.

 

 

 

On Wheldon protocol for MS since April, 2006.  doxy 200 mgs daily, zithromax 250 mgs 3x/ week , LDN 2004

5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tini pulses,100 mg diflucan, 4.5 ldn; Wheldon protocol for MS April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.

See the Brorson tini paper (free online) for one ref suggesting in some way that tini might be somehow anticandidal, or antifungal, or something like that.

For me it decidedly favors lingual candida, and I know at least one person who had particular yeast problems with a nitroimidazole (worse than with other antibacterials).

D W

Metronidazole and tinidazole are nitroimidazole agents effective against susceptible bacteria whose metabolism operates in an anaerobic mode. Fluconazole and related agents have antifungal properties. They are different classes, have different uses. It doesn't help that the latter fungicides are familiarly (and loosely) called 'azoles'. That may be where the confusion arises.

D W - [Myalgia and hypertension (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazole. No medication now. Morning BP typically 110/75]

David- I'm betting you hit it on the head. My bet is your pharmacist friend is confusing the antifungal "azoles" with the nitroimidazole agents (flagyl and tini). If the latter are classified as antifungals in Britain, well it's just bloody wrong!

Combined Antibiotic Protocol for Chlamydia pneumonia in Chronic Fatigue Syndrome & Fibromyalgia- Currently: 150mg INH, Doxycycline/Zithromycin, Tinidazole pulses. Northern Ohio, USA

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

D W

Wires seem to be crossed. Here's a succinct link to metronidazole and its action: link. Active against anaerobic bacteria and some protozoa. Not an antifungal, and not so recognized. I don't understand Jim's reference to Britain.

D W - [Myalgia and hypertension (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazole. No medication now. Morning BP typically 110/75]

I think your earlier assessment that the pharmacist friend was confusing metronidazole as one of the "azoles" is likely.  It's very pobably just a case of mistaken drug identity. 

all my best

John

RRMS/EDSS 4.5 on Wheldon Protocol (doxycycline, azithromycin, metronidazole) since 04/12/2006

best, John

RRMS/EDSS was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
nac 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazole 3x400mg/day then 3x500mg/day

This is a good, basic reference on metronidazole. Thanks David. Quite, quite. Jolly good. Hrrmph! 

Combined Antibiotic Protocol for Chlamydia pneumonia in Chronic Fatigue Syndrome & Fibromyalgia- Currently: 150mg INH, Doxycycline/Zithromycin, Tinidazole pulses. Northern Ohio, USA

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral