27 Apr 2018
Author
D W
Title

Antibiotic associated diarrhoea

Body

I've just added a page to my site; it is about antibiotic-associated diarrhoea. I've not come across this in the treatment of MS with antibiotics; doxycycline and azithromycin seem to be uncommon causes of AAD, and, paradoxically, metronidazole, which is used for treating AAD, can, on rare occasions, cause it. Personally, I don't think it's a big issue, but it would be irresponsible not to mention it. Diarrhoea is quite common during the antibiotic treatment of chronic C. pneumoniae infection, possibly because of infection of the autonomic nervous system which innervates the gut.

Comments

I use product "Pangamin", which is mix of all B vitamins, some minerals, lactobacili and bifidobacteria plus sacharomyces cerevisiae. S. boulardii is not available here. So I suppose s. cerevisiae has also some beneficial effect or similar to s. boulardii.

Prague, The Czech Republic, On Wheldon protocol for Cpn and Mycoplasma since 02/18/2006.

Stratton/Wheldon protocol 02/2006 - 10/11 for CFS and many problems 30 years

David          

I wonder how possible/likely that AAD by doxy/azi/flagyl is in reality apoptosis of intestinal lining / cells?  I think it's likely that's what happened to me last month as the first fourt months I had no problems of that sort, it was only at the tail end of my third pulse. 

all my best

John

RRMS/EDSS 4.5 on Wheldon Protocol (doxycycline, azithromycin, metronidazole) since 04/12/2006

best, JohnRRMS/EDSS was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006nac 4x600 mg/daydoxycycline 2x100mg/dayazithromycin 3x250mg/day MWFmetronidazole 3x400mg/day then 3x500mg/day

DW I am SO GLAD you did this page. It has been something we have needed refeence to for a while. We did have one member, a patient of Dr Powells I think I remember, have to leave due to severe c diff.-weight loss and the whole 9 yards. It can happen so I am glad we can reference your well done page THANK YOU so very much. I use s boulardii in addition to a heat stable probiotic.
marie
On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.
"Color out side the lines!"

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

I have C Dif whenever I take ABX now and cant tolerate them, its frustrating because they seem to be the only thing that clears up the brain fog. I was thinking that if someone started the Pro biotics first and then went onto the antibiotics perhaps they wouldnt have such a negative affect

Jeanmw

Jean, how did you end up here? You are surrounded by posts over ten years old! My answer is, why not take probiotics every day?

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Marie, I've wondered about her sometimes, do you know if she's doing OK with the C diff?

I recently heard that ~1/5 of clinical C diff cases may result in chronic GI symptoms (of unclear mechanism), according to certain reports. I had not realized this. This new information certainly increased my level of concern over C diff disease -- in the past I'd had basically no concern, as I had (apparantly incorrectly) assumed that the disease was almost always resolvable. I'm now quite interested in C diff prevention.

I emailed her and asked her to write. maybe we'll hear soon! She is still an active member and last post was 3/06 but has visited since then so I hope we get a hello!
marie
On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.
"Color out side the lines!"

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

John- I don't think the "tail end"  of your third pulse was an intentional play on words but...

Actually, I agree with you that the intestinal epithelium is also a site for Cpn infection, and perhaps a major one at that. The pictures of Cpn in the image gallery from Dr. Stratton include at least a couple of Cpn infectiong gut tissue. I know a lot of my gut symptoms have improved and cleared over the course of treatment, and I don't think it was neural ANS problems, but rather gut toxicity itself.

David- another great addition to your site. A very solid source of clinical info. I hope this entry isn't the "tail end." 

Combined Antibiotic Protocol for Chlamydia pneumonia in Chronic Fatigue Syndrome & Fibromyalgia- Currently: 150mg INH, Doxycycline/Zithromycin, Tinidazole pulses. Northern Ohio, USA

David, Only a medical professional could get away with posting under this indelicate heading!

 As for cpn infection in mysterious places, Jim, my supremely painful but non-functional gallbladder resumed function within two weeks of starting dual antibiotics.  I was scheduled to have it out on 20 October last year and started abx on 06 October.  By the 16th, it was evident something had happened (I actually felt it go 'pop', like it inflated fully).  My surgeon ran one last function test prior to the scheduled surgery and said he'd never seen anything like it.  He also joked he was glad he's near the end of his career, if abx therapy is now going to cure all the diseased gallbladders...    Then he passed the abx protocol on to his former partner, who retired due to her progressive MS.  Everything happens for a reason.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems.  Mohandas Gandhi

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

took my first abx this morning and just spent the last 30 mins in the toilet :/

Hope this isn't a regular occurrence

Diagnosed RRMS 1999. No DMDs or other meds. Have done TMJ correction, Candida protocol, CCSVI venoplasty procedure.

Oh, it wears off: at least you made it to the loo, which is more than I did!

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

i hope it does, not sure if i can do this for 12+ months surprise

Diagnosed RRMS 1999. No DMDs or other meds. Have done TMJ correction, Candida protocol, CCSVI venoplasty procedure.

Oh, my rushing to the loo only lasted a couple of days!

 

 

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

I spent the first ten days or so (I started doxycycline and azithromycin at the same time) too frequently in this state.  My behind HURT.  I likened it to what happens when you eat spicy food, except it went on for DAYS and DAYS.  

When I finally decided 'if this is the price I pay to get better, then so be it', it stopped.  It was a not so pleasant ten days or so, though.  lol  

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

D W