Submitted by Jim K on Sat, 2006-01-14 15:05

As we know, Cpn binding endotoxin uses up melatonin and supplementation has been helpful to a lot of us. In addition it's an excellent antioxidant. The study below adds even another reason to supplement it:

J Pineal Res. 2005 Oct;39(3):266-75.

Melatonin neutralizes neurotoxicity induced by quinolinic acid in brain tissue culture.

Vega-Naredo I, Poeggeler B, Sierra-Sanchez V, Caballero B, Tomas-Zapico C, Alvarez-Garcia O, Tolivia D, Rodriguez-Colunga MJ, Coto-Montes A.

Departamento de Morfologia y Biologia Celular, Facultad de Medicina, Universidad de Oviedo, Oviedo, Asturias, Spain.

Quinolinic acid is a well-known excitotoxin that induces oxidative stress and damage. In the present study, oxidative damage to biomolecules was followed by measuring lipid peroxidation and protein carbonyl formation in rat brain tissue culture over a period of 24 hr of exposure to this prooxidant agent at a concentration of 0.5 mm. Quinolinic acid enhanced lipid peroxidation in an early stage of tissue culture, and protein carbonyl at a later stage. These data confirm and extend previous studies demonstrating that quinolinic acid can induce significant oxidative damage. Melatonin, an antioxidant and neuroprotective agent with multiple actions as a radical scavenger and signaling molecule, completely prevented these prooxidant actions of quinolinic acid at a concentration of 1 mm. Morphological lesions and neurotoxicity induced by quinolinic acid were evaluated by light microscopy. Quinolinic acid produced extensive apoptosis/necrosis which was significantly attenuated by melatonin. Cotreatment with melatonin exerted a profound protective effect antagonizing the neurotoxicity induced by quinolinic acid. Glutathione reductase and catalase activities were increased by quinolinic acid and these effects were antagonized by melatonin. Furthermore, melatonin induced superoxide dismutase activity. Quinolinic acid and melatonin acted independently and by different mechanisms in modulating antioxidant enzyme activities. Our findings using quinolinic acid and melatonin clearly demonstrate that such changes should always be seen in the context of oxidative neurotoxicity and antioxidant neuroprotection.

PMID: 16150107 [PubMed - in process]=


I am intrigued by the multi-benefits of melatonin--especially it's antioxidant effects.  I would love to try taking it, but my psychiatrist warns against it until I can completely get off of the Zoloft/WellbutrinXL/Trazodone.  I take these meds primarily to benefit from their side effects.I  first began needing Trazodone for insomnia about eight years ago. Two years later I had to add Zoloft for mood/energy.  Normally, a typical 'depressive episode' begins with one's mood/chemical imbalance being primary, then insomnia tends to follow.However, I have always been suspicious as mine began with insomnia--and it was two years later that mood became an issue deemed necessary to medicate with Zoloft.  Vitamin "Z", as I playfully call it, has been my magic bullet.  Since starting the Wheldon protocol in Oct '05, I have been able to cut my doses of both in half!  I imagine we all hope to not even need melatonin someday.  What a glorious day it will be!  [some credit goes to Steely Dan, as his song goes through my mind a lot :)] I    

Wheldon Protocol for rrms since Oct '05.  Added LDN 4.5mg qhs Oct '07.  All supp's.  Positive IGG's for Lyme Disease,Babesia, & Erlichiosis Sept. 2008.  Currently:  Mepron 750mg bid and Azithromycin 250mg qd for Babesia.

The caution to not take melatonin if you are taking antidepressants could be overdone. I take, and admitedly low dose, Cymbalta (30mg) for energy and mood to counter the effects of Cpn in these areas a bit. I have been able to build up to 6mg of melatonin at night with no ill effects-- I take the Cymbalta in the morning. Melatonin appears to work best when taken earlier in the evening, right after dinner for some, where it can act as a re-regulator of pituitary-hypothalamic process and assist in re-timing your circadian rythms. So, with your doctors assent, you might cautiously try adding it around this time, since your other meds are more likely right at bed time. Ask your doctor what negative effects he would expect so you can watch for them-- I'm betting he doesn't know what they would be, since the caution doctors receive usually has been "Melatonin is contraindicated for those taking antidepressants" with no explanations given. On Wheldon/Stratton protocol for Cpn in CFS/FMS since December 2004.

For months I have resisted facing the fact of sleep problems.  This has crept up slowly and unnoticed because I no longer take naps, until I am very tired some days lately- not MS fatigue but plain old sleep deprivation tired.  Two nights ago I took 1/2 of the recommended dose, woke at 2:30 and took the other 1/2 and slept pretty well the rest of the night.  Last night I took the whole pill at 9 (2 hours before charcoal) at 11 went to sleep and woke wonderfully refreshed at 6 after sleeping soundly the whole night.  I am sold.  When we have MS we are just not normal!  Until further notice, melatonin is part of my 45 to 50 pill per day regimen.  Maybe I will be normal again someday!  It's ok cause every day is  one day down that road. Rica Ignorance is voluntary bad luck.  Lauritz S.   A true Viking If you come to a fork in the road, take it. Yogi Berra

3/9 Symptoms returning. Began 5 abx protocol 5/9 Rifampin 600, Amox 1000, Doxy 200, MWF Azith 250, flagyl 1000 daily. Began Sept 04 PPMS EDSS 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

Info on melatonin/drug interactions:From,3926,4060%7CMelatonin,00.html  MelatoninOther Names: MEL, MLT, N-acetyl-5-methoxytryptamineWhat interactions should I watch for?Prescription DrugsStudies have revealed that melatonin may interfere with the blood pressure-lowering effects of nifedipine GITS (Procardia XL). As a result, blood pressure was not controlled. Another medication used for blood pressure, verapamil (Calan, Isoptin, Verelan), reduced the effectiveness of melatonin when they were taken at the same time. Whether melatonin and other high blood pressure medicines interact is not known. If you take medicine for high blood pressure, talk to your doctor or pharmacist before you take melatonin.Fluvoxamine (Luvox), an antidepressant, is known to increase natural melatonin production and it may also increase blood levels of melatonin if it is taken at the same time as melatonin supplements. If fluvoxamine and melatonin are taken together, the risk for side effects of melatonin may be increased. Other antidepressant medications may also interact with melatonin. If you take an antidepressant, do not take melatonin.Because it can enhance immune system function, melatonin may interfere with the effects of drugs used to suppress the immune system after organ transplants or in other conditions. Taking melatonin is not recommended for patients who take drugs such as:    * azathioprine (Imuran)    * corticosteroids    * cyclosporine (Neoral, Sandimmune)    * daclizumab (Zenapak)    * mycophenolate (CellCept)    * sirolimus (Rapamune)    * tacrolimus (Prograf)Melatonin opposes the action of natural corticosteroids and corticosteroid drugs, which are used for a wide range of inflammatory conditions including arthritis, asthma, cancer, eye conditions, and skin infections. When supplemental melatonin is taken at the same time as corticosteroids, the effects of the corticosteroid may be decreased. It is best not to take melatonin and corticosteroids at the same time. Commonly prescribed corticosteroids include:    * beclomethasone (Beconase, Beclovent, Vancenase, Vanceril)    * dexamethasone (Decadron)    * hydrocortisone    * methylprednisolone (Medrol)    * prednisolone    * prednisone (Deltasone, Orasone)    * triamcinolone (Azmacort, Nasacort)When melatonin is used with prescription drugs that promote sleepiness, the effects of the drug may be exaggerated, resulting in sedation or mental impairment. Prescription drugs that may cause sleepiness include:    * Anticonvulsants such as carbamazepine (Tegretol), phenytoin (Dilantin), and valproic acid (Depakote)    * Barbiturates such as phenobarbital    * Benzodiazepines such as alprazolam and diazepam (Valium)    * Drugs for insomnia such as zaleplon (Sonata) and zolpidem (Ambien)    * Tricyclic antidepressants such as amitriptyline, amoxapine, doxepin and nortriptylineIn animal studies, melatonin has increased the anti-seizure effects of the anticonvulsant drugs, carbamazepine (Tegretol) and phenytoin (Dilantin).Non-prescription DrugsThe sleep-producing effects of over-the-counter products containing diphenhydramine can be enhanced by taking melatonin at the same time. Diphenhydramine is contained in many over-the-counter sleep aids as well as in some cough and cold products, therefore caution should be used when taking these medications with melatonin because excessive drowsiness may result.Herbal ProductsMelatonin may cause excessive sedation if taken with sedating herbs such as:    * Catnip    * Hops    * Kava    * St. John's Wort    * ValerianFoodsIn several small studies of humans, caffeine has been shown to reduce the amounts of melatonin that the body produces naturally and also to block supplemental melatonin.No other interactions between melatonin and foods have been reported, but drinking alcohol at the same time as taking melatonin may result in increased drowsiness.Some interactions between herbal products and medications can be more severe than others. The best way for you to avoid harmful interactions is to tell your doctor and/or pharmacist what medications you are currently taking, including any over-the-counter products, vitamins, and herbals. For specific information on how melatonin interacts with drugs, other herbals, and foods and the severity of those interactions, please use our Drug Interactions Checker to check for possible interactions.

Thanks again, JimIt is really nice to find that I take no meds that are contraindicated with this new wonder, melatonin and have very low blood pressure.  One of the wonderful things about this site is that every question will be answered without bias. Rica Ignorance is voluntary bad luck.  Lauritz S.   A true Viking If you come to a fork in the road, take it. Yogi Berra

3/9 Symptoms returning. Began 5 abx protocol 5/9 Rifampin 600, Amox 1000, Doxy 200, MWF Azith 250, flagyl 1000 daily. Began Sept 04 PPMS EDSS 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

Thanks JimK!  I will definitely bring a copy of this to my psy. next time I see her.  I would love to incorporate melatonin into my regime.  Glad to see that it is working well for so many.KK2  :)

Wheldon Protocol for rrms since Oct '05.  Added LDN 4.5mg qhs Oct '07.  All supp's.  Positive IGG's for Lyme Disease,Babesia, & Erlichiosis Sept. 2008.  Currently:  Mepron 750mg bid and Azithromycin 250mg qd for Babesia.

Melatonin gives me a headache since starting antibiotics. I wonder what the connection is and if I should not take melatonin.

minocycline, azithromycine, metronidazole 2007-2009, chelation for lead poisoning, muscle pain, insomnia, interstitial cystitis (almost well), sinus, dry eyes, stiff neck, veins, hypothyroid, TMJ, hip joints (no longer hurt)

My chelation doctor mentioned her dosage of melatonin, "I take 3mg per night, and if that's not enough, I take 6mg. Experimentally, people have taken as much as 15mg." 

RonOn CAP for CFS starting 01/06 (NE Ohio, USA)Began rifampin trial 1/14/09Currently: on intermittent

I've read recently that Melatonin is a 5HT2A antagonist. I cannot now find the link however.

Doxy 100mgx2, Azithromycin 250mg MWF, Probiotics: PB8, JarrowDophilus. CFS since 2003. Last 5+ years lots of the usual research (Depression, Adrenal Fatigue, HPA, Mercury, Candida, Thyroid, etc.). $5 coupon code: HAW103