Age-related Macular Degeneration
Age-related macular degeneration is one of the commoner causes of visual impairment in the elderly. See: http://www.amd.org/site/PageServer The pathology starts much earlier, though. The symptoms are loss of clarity in the centre of the visual field. As the disease progresses a grey smudge fills the centre of vision. There is evidence of an association with cpn. Vigorous treatment with antioxidants and mitochondrial support supplements may stop its advance.
"A combination of supplements (acetyl L-carnitine, CoQ10 and n-3 oils) was found to improve and stabilize vision in age-related macular degeneration (AMD). [Feher J et al., Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl L-carnitine, n-3 fatty acids, and coenzyme Q10. Ophthalmologica. 2005 May-Jun;219(3):154-66.] AMD is a condition with a multifactorial aetiology, one factor being possible chronic infection with Chlamydia pneumoniae [Ishida O et al., Is Chlamydia pneumoniae infection a risk factor for age related macular degeneration? Br J Ophthalmol. 2003 May;87(5):523-4; Kalayoglu MV et al., Serological association between Chlamydia pneumoniae infection and age-related macular degeneration. Arch Ophthalmol. 2003 Apr;121(4):478-82; Robman L et al., Exposure to Chlamydia pneumoniae Infection and Progression of Age-related Macular Degeneration. Am J Epidem 2005 161(11):1013-1019.] AMD is a disorder characterized by mitochondrial depletion and damage. [Feher J et al., Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration.Neurobiol Aging. 2005 Jun 22.] If the link between AMD and cpn is further ascertained, AMD may be considered a paradigm of chronic progressive infection with Chlamydia pneumoniae. Improvement following antioxidant treatment is significant." (edited excerpt from http://www.davidwheldon.co.uk/supplement_rationale.html