Acute Chlamydia pneumoniae infection in the pathogenesis of autoimmune diseases

Lupus. 2009;18(2):164-8.

Acute Chlamydia pneumoniae infection in the pathogenesis of autoimmune diseases.

Department of Clinical Immunology and Rheumatology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan

Autoimmune diseases have several etiologies. Acute Chlamydia pneumoniae (C. pneumoniae) infection may be involved in the pathogenesis of several autoimmune diseases. In this study, 82 patients with several autoimmune diseases and 70 controls were enrolled, and acute C. pneumoniae infection has been evaluated by monitoring the levels of IgM antibody. Chlamydia pneumoniae IgM positive results were observed in 29% (P < 0.05) of the patients with several autoimmune diseases and in 10% of the controls. Chlamydia pneumoniae IgM positive cases were more frequent among the patients with rheumatoid arthritis (RA; 30%, P < 0.05), systemic lupus erythematosus (SLE; 28.0%, P < 0.05), dermatomyositis/polymyositis (23%, NS), myeloperoxidase-antineutrophil cytoplasmic autoantibody (MPO-ANCA)-associated vasculitis (33%, NS), adult onset of Still's disease (29%, NS) and giant cell arteritis/Takayasu arteritis (50%, NS) than among the controls. This positive frequency was statistically significant in RA and SLE. These results suggest that acute C. pneumoniae infection is probably involved in the pathogenesis of autoimmune diseases.


What crossed my mind is that you are always very colorful, and this description surpasses even your usual. 

I was going to leave it at that and then I saw your latest signature.  With great suspense the story goes on.  Really, I can hardly wait to hear the reactions.

How much D3 do you take? 



3/9 Symptoms returning. Began 5 abx protocol 5/9 Rifampin 600, Amox 1000, Doxy 200, MWF Azith 250, flagyl 1000 daily. Began Sept 04 PPMS EDSS 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

Hi, Rica! Short answer: no reaction at all. I feel better on Rifampin than I did on my last Flagyl pulse. I take a lot of natural Cod Liver Oil, but no D3, yet: don't want to muddy the Rifampin-reaction waters (as if they weren't already!)

I don't want to highjack this thread, so I've promised myself to post a blog update this weekend. I was kind of waiting for the other shoe to drop, but I am beginning to think that I'm going to sail through the 6 weeks of Rifampin. I guess I might start writing my "Patient Story," too -- but I'm hoping to write about complete remission, and that's not occurred as of now.

 Thanks for asking. I might be joining you as a CAPper emeritus!


On CAP for CFS starting 01/06 (NE Ohio, USA)

Began rifampin trial 1/14/09

Currently: on intermittent

Ron looking forward to your blog! I agree with teh demons/autoimmunity thing LOL!!

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro