Submitted by Jim K on Sat, 2006-01-21 20:33

Does it work?

It has been noted that most users of the combination antibiotic protocols commenting here have not been on the treatment long enough to give a big enough pool of reports to feel assured of the efficacy of this approach. I had asked Drs. Stratton, Wheldon, and Powell to perhaps tally up at least some basic numbers from their case experience to help us out with this problem, but this would involve problems of confidentiality and use of private data, etc.   Then, I suddenly realized that we already have a good list of anecdotal reports of response to treatment reported data available to us... right in the Stratton/Mitchell patent materials! (Sheepish, embarrassed grin). So I took it as a project to summarize this data by disease treated. Occasionally I have used the exact wording from the patent materials as they were brief and descriptive. We have the full text referenced in our treatment and links if you want to see more detail. All reported had with positive serology for Cpn using the highly sensitive tests developed by Stratton/Mitchell. I left out a few whose diagnosis was not clear to me, you can see them in the patent materials #6,884,784 All on some form of the combination antibiotic therapy protocol.


  1. EDSS score 8.0- Treatment nine month- EDSS 3.0
  2. EDSS score 8.0 Treatment six months- EDSS 6.5
  3. EDSS score 7.5.  Treatment five months- EDSS 6.5.
  4. EDSS score 8.5  Treatment six months- no further progression of symptoms
  5. 10 years wheel chair  bound  Treatment six months- stands unaided, several steps, dec fatigue and cognitive dysfunction.
  6. Long hx MS with 2-3 year progression   Treatment fourteen months- improved incontinence, stamina, speech. Continues to be wheel chair bound.
  7. One year MS, foot drop, walks with cane.   Treatment four months- no longer requires cane.
  8. One year MS. Cane, rolling gait, fatigue.   Treatment twelve months- no cane, no fatigue on walking



Treatment two months. Complete remission of RA symptoms.


Treatment two months. Complete remission of symptoms. Stopped tx, return of IC symptoms.


  1. Treatment six months. No further evidence of IBD. Bowel habits normal, no steroids, cognitive dysfunction and depression resolved.
  2. Treatment six months. No further evidence of IBD. Neurologic, fatigue, myalias, athralgias, rash resolved.
  3. Six year history of inflammatory bowel disease (uncertain CD or UC) associated with painless rectal bleeding, arthritis, myalgias, skin ulceration, abdominal cramping/diarrhea, and rectal fistulas. She had increasing fatigue. Symptom free (after going off abx on vacation and relapsing) after one year of treatment. On combination antibiotics her ileostomy activity was more regular and less spastic. She claimed to feel better with higher energy levels and ceased antibiotic therapy. Six months post- antibiotic therapy she remained asymptomatic other than a moderate anemia.
  4. On combination antibiotics she experience some symptomatic improvement but failed to completely resolve her IBD symptoms. She discontinued antibiotics due to a probable chronic Herxheimer reaction. Currently she is lost to follow-up.
  5. Colitis with inflamed distal sigmoid colon and proctitis associated with frequent loose stools with significant mucus. Following six weeks of combination antibiotic therapy with a significant reduction in symptoms. Shortly after cessation of antibiotics her symptoms return. Reinstitution of antibiotics resulted in a second remission of the majority of her symptoms with resolution of her proctitis on visual exam.



  1. Insidious onset of debilitating fatigue. This was associated with a severe cognitive dysfunction that disrupted his ability to function. Combination antibiotics with complete reversal of symptoms after six months. He remains asymptomatic.
  2. 10 year history of CFS with severe cognition problems. Herxheimer reaction with resolution over two week period on treatment. He remains on combination antibiotics for over ayear and is asymptomatic.
  3. Physician with long-standing CFS. Treated with combination antibiotics with gradual resolution of symptoms. During course of treatment developed cardiac myopathy. Currently asymptomatic from CFS. Cardiac myopathy resolved over six month period on combination antibiotics.
  4. Five year history of severe CFS with debilitating cognitive dysfunction and depression. Gradual improvement on combination antibiotics for approximately nine months. Estimated 75% of normal function.
  5. Ten year history CFS with cognitive dysfunction. Complete response to combination antibiotics over a course of one year.
  6. Moderate fatigue and cognitive dysfunction following acute infectious illness. Depression was major problem. During one year course of combination antibiotics fatigue and cognitive dysfunction largely reversed. During mid-course of therapy patient developed acute anxiety attacks relieved by anti-porphyrin therapy.
  7. Fatigue following acute stress. On combination antibiotic therapy at 3 months became asymptomatic. Cessation of antibiotics resulted in symptomatic relapses. Currently asymptomatic with low serum antibodies and negative PCR.
  8. Short history of CF and cognitive dysfunction affecting studies. Combination antibiotics over a multi-month course resulted in complete reversal of symptoms.
  9. Three year history of CFS with FM. Combination antibiotic therapy has resulted in partial reversal of symptoms allowing her to retain a job in jeopardy. Estimated 80-90% normal function currently.
  10. History of fatigue although non-incapacitating. Combination antibiotic therapy has resulted in 100% return to normal function.
  11. Teen-ager with long history of CFS resulting in home-bound schooling. On combination antibiotic therapy returned to school and recently graduated. Recovery has not been complete probably secondary to non-compliance in therapy.


Three year history of debilitating FM following the stress of being a stalking victim. Patient relatively asymptomatic after nine months combination antibiotic therapy.

Siram's cases

You will find followup reports from Dr. Siram's cases by a man who actually tracked down personally those he could find. These are all MS cases, and all report improvement, some quite spectacular, such as the wheelchair bound tri-pelegic former cop who was able to resume his former job! But please note: some people used flagyl, and other antibiotics only. The inconsistencies of degree of improvement seems mostly due to this factor in my read. Remember that this was in 1994 when the understanding of the importance of the whole protocol, especially the critical importance of flagyl, was still evolving. Click here for link.