MediTest
27 Apr 2018
Author
golfbuddy
Title

1500mg pulse

Body

I am 4 hours post 1500 mg pulse of Flagyl.  I am CFIDS (as far as I can tell by my own diagnostic capabilities) and so far just ringing in the ears and a little foggy.  Just did the charcoal caps now.  It may not even been worth asking if I end up floored tonight or tommorrow but I was curious to hear from Jim or Paul weighing in on my next dose.....skip a day and do the same thing?....Wait a a few days or a week?.....Convert to the usual protocol for the next 4 days?I have been tolerant of higher doses before.  For some reason I always did better with twice a day than 3x, so I have done 10

Comments

Golfbuddy- So far, jury is still out for me on the high-dose vs regular pulses. I did about 4 high dose pulses with manageable results, and then last week did a high dose start (2 grams) followed by 4 days of regular pulse (500mg twice a day) just to compare. I have to say that this last one has engendered joint pains i haven't had since at least four pulses back, making me think that the short high dose pulses are long enough to reach deeply enough into some tissues, or to build up blood levels over a long enough time span. Certainly the initial "loading dose" made for a much quicker effective dose on the pulse.

The downside is I'm still feeling inflammation in joints and muscles a week later. I haven't had widespread inflammation, something which had been a chronic condition for years, since beginning of March when I had adjusted to the addition of INH. This tells me not to get uppity about pushing the protocol too fast when it seems things are improving.

On CAP's protocol for Cpn in CFS/FMS since December 2004.
Currently: 150mg INH, Doxy/Zith, Tini pulses 

"I really didn't say everything I said." Yogi Berra

Hi Golfbuddy,

I am an advocate of the larger single pulses. I believe they have generally allowed me to make faster progress with less side effects. However there are certainly some side effects so no one should try going too fast if they are considering doing this. [Reference to Marie attempting suicide by antibiotics by taking 2 grams early on.] I generally think it is better to take a bit lower dose and do it every other day or 3 times a week as Cpn have a slow growth cycle that takes 2-3 days so taking this more often does not seem very advantageous.

I am currently taking 1 gram Flagyl pulses with 600 mg of Rafampin every other day. This is not for the faint of heart and something you should build up to if you consider trying it. But the results have been very good for me so far. I know a few other people who are taking single larger doses of Flagy, 1 gram, 2-3 times per week and doing well also. BTW if anyone does consider pulsing Flagyl with Rifampin they should probably lower the Flagyl dose initially. The effect is at least additive if not synergistic and you can make the same progress with less Flagyl IMO.

- Paul

Thanks Paul.  I seem to have done ok now at 24 hours post 1500mg of Flagyl.  Except for waking up every few hours and a little fog this morning, I seem ok.  I decided to try my first Vit C flush when I woke up, before taking anything else so that is in progress.  So I am going to have to decide about skipping a day with Flagyl or not, and how to come up with the best schedule for myself since I don't have a lot of symptoms on it except nausea and fog.  I am thinking of switching to Tini as well due to comments here.  I appreciate your input.  I am nervous about adding Rifampin or INH as I have had mildy elevated AST and ALT and am watching my liver closely.

 Golfbuddy- You might consider pulsing the INH with the Flagyl/Tini if you are handling that well. Dr. Stratton seems to think this is a good way to do it, I think Daunted has been following this course although not with the high dose pulses. It is a way to use the INH but protect more against the liver toxicity issues.

Pulsing the Rifampcin is an experimental thing Paul is trying based on Rifampcin inhibiting bacterial efflux pumps, and I'd hold off on that until there's a little more anectdotal info on it. I'm likely to be a guinea pig for that one, to which Dr. Powell suggested I need to get an ear tag to keep track of me in the lab! I'm not sure if that was just medical humor, or if there was an oblique message there, "So you want to treat yourself like a lab rat" I thought you were feeling better..."

On CAP's protocol for Cpn in CFS/FMS since December 2004.
Currently: 150mg INH, Doxy/Zith, Tini pulses 

"I really didn't say everything I said." Yogi Berra

Thanks Jim,

 I will see what my next LFT's are and decide about pulsing INH.  Today I am trying to decide whether to take nothing or at least another 500 or 1000mg.  I think I kind of like the idea of having a bad week and then a few weeks of more normalcy rather than every other day.

 

Golfbuddy,

That post was written during a combination Flagyl/Rifampin pulse. I am actually taking 300 mg of Rifampin with 1 gram of Flagyl. The good news is that I would have missed the keys completely a few months ago trying to type during a Flagyl pulse ;)

Regarding INH and Rifampin on the liver, they both worry me but my anecdotal input is that INH is harder on it (My liver actually hurts when I take it.) but Rifampin at 300 mg with Flagyl seems to to be OK. OTOH INH seems to get great tissue penetration. It felt like it hit some spots that Flagyl did not have much effect on, particulary areas one would presume would get lower drug concentration such as feet, skin, and CNS. I definitely plan on using INH at a later date when I feel that the Cpn load in my liver has dropped.

- Paul 

Hi As Paul said for the MS patient and especially early in the game, DO NOT USE high dose pulses. I used that approach at pulse 5 due to an intense curiosity about the idea and to get it over with and be "done' pulsing in a weekend and not be doing it all week. I took 2 gm at once (with my doctor's OK) and had a severe reaction. My hand is still not back completely vs prepulse and I am now at pulse 7. For the MS patient there is no shortcut. You can read the CPn handbook pages on The brain and pathogenic treatment to get details. I knew this stuff before I did that pulse, one might wonder if I was dim, but the fact of tha matter was I was interested in the idea and wanted to experiment. SO I was my own lab rat! Some of us are the curious type...I'll be more respectful of my poor brain in the future .
marie

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

 Marie- We can all get our numbered little metal ear tags, the latest style in lab rat wear! Ah, another money raiser for Cpnhelp! I have one ear pierced, maybe...

On CAP's protocol for Cpn in CFS/FMS since December 2004.
Currently: 150mg INH, Doxy/Zith, Tini pulses 

"I really didn't say everything I said." Yogi Berra

There we go a little CPnhelp eartag.i love it! Can I get mine pink to go with my nailpolish?
Marie

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

I'm sorry, no ear tag for my Jim. I'm requesting a collar and LEASH!!! Feeling a bit naughty today. Lexy

---------------
"Chance favors the prepared mind." --Louis Pasteur

Husband treating MS with CAP

What Lexy! My goodness. He must be a handful!
Marie

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro